A5100325047- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine Tumor Research Advances
- Ion Channels and Receptors
- Sodium Intake and Health
- Renin-Angiotensin System Studies
- Birth, Development, and Health
- Pancreatic and Hepatic Oncology Research
- Inflammatory mediators and NSAID effects
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Pregnancy and preeclampsia studies
- Colorectal Cancer Screening and Detection
- Microtubule and mitosis dynamics
- Occupational and environmental lung diseases
- 14-3-3 protein interactions
- Musculoskeletal Disorders and Rehabilitation
- Immune Response and Inflammation
- Hereditary Neurological Disorders
- Mycobacterium research and diagnosis
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Immune Cell Function and Interaction
Prince of Wales Hospital
2024
UNSW Sydney
2024
La Trobe University
2023-2024
Rice University
2021
Cornell University
2019
Weill Cornell Medicine
2019
Imperial College London
2017
Icahn School of Medicine at Mount Sinai
2002-2017
Mount Sinai Health System
2017
Medical College of Wisconsin
2012-2014
Background: Diagnosis of malignant mesothelioma often requires differentiating it from other metastatic malignancies including breast cancer, lung ovarian colorectal etc. Immunohistochemical stains (IHC) are important means to assist in confirming and ruling out cancers. Although mesothelial specific markers have been used for diagnosis, aberrant immunostains were also observed clinical practice which confounded the diagnosis. In this study, we analyzed positive rate commonly IHC diagnosis...
The identification of genetic material from pathogenic organisms in ancient tissues provides a powerful tool for the study certain infectious diseases historic populations. We have obtained tissue samples genital areas 12 mummies American Museum Natural History collection New York, N.Y. were excavated Andes Mountain region South America, and radiocarbon dating estimates that date A.D. 140 to 1200. DNAs successfully extracted all suitable PCR analysis. PCRs carried out detect Mycobacterium...
High-throughput screening and subsequent optimization led to the discovery of novel 3-oxazolidinedione-6-aryl-pyridinones exemplified by compound 2 as potent selective EP3 antagonists with excellent pharmacokinetic properties. Compound was orally active showed robust in vivo activities overactive bladder models. To address potential bioactivation liabilities 2, further resulted compounds 9 10, which maintained potency, selectivity, properties no liability glutathione trapping studies. These...
Objective Small intestinal neuroendocrine tumors (SI-NETs) are often detected after they have become metastatic. Using a novel protein array, we identified pathways important in SI-NET metastasis development surgically resected patients. Methods Paired primary and liver metastases from 25 patients undergoing surgical resection for metastatic SI-NETs were harvested. Extracted proteins separated by sodium dodecyl sulfate gel multiplex immunoblots performed with 136 antibodies. Significant...
Vascular inflammation and fibrosis are hallmarks of hypertension contribute to the development cardiovascular disease cognitive impairment. However, current anti-hypertensive drugs do not treat underlying tissue damage, such as inflammation-associated fibrosis. Human amnion epithelial cells have several properties amenable for treating vascular pathology. This study tested effect on pathology impairment during hypertension. Male C57Bl6 mice (8-12 weeks) were administered vehicle (saline; n =...
Hypertension is a major risk factor for both stroke and cognitive impairment, but it unclear whether may specifically affect post-stroke impairment. We assessed the effect of hypertension and/or on brain injury, outcome, transcriptomic profile. C57BL/6J mice (n = 117; 3–5 mo.) received s.c. infusion either saline or angiotensin II followed by sham surgery photothrombotic targeting prefrontal cortex seven days later. Cognitive function was with Barnes maze RNA sequencing used to quantify...
Background and purpose: Hypertension increases the risk for cognitive impairment promotes vascular renal inflammation. We tested if immune cell infiltration occurs in brain during hypertension it is associated with impairment. Experimental approach: Male C57Bl/6 mice were administered vehicle, angiotensin II (0.7 mg/kg/d S.C.) or aldosterone (0.72 via osmotic minipumps. A subset of also received hydralazine (50 mg/kg) their drinking water after minipump implantation. measured systolic blood...
Endothelial TRPV4 is a Ca 2+ entry channel contributing to endothelium‐mediated dilation in conduit and resistance arteries. In previous studies, we found that chronic infusion of angiotensin II (AII) reduces mesenteric arteries (MAs) from wild‐type (WT) but not TRPV4‐KO mice. Here investigated whether AII impairs endothelium‐dependent by reducing expression or function. protein was examined MAs AII‐treated WT mice human coronary artery endothelial cells (HCAECs). (600 ng/kg/min for 14 days)...
Introduction: Vascular stiffening and inflammation are hallmarks of hypertension contribute to the development cardiovascular disease cognitive impairment. Current treatments for may reduce blood pressure but do not target associated pathological changes end-organ damage. It is also inconclusive from clinical trials whether anti-hypertensive medication can improve Cell therapy has great therapeutic potential as unlike single pharmacological agents, cells deliver multiple mediators which...
Abstract Study question Is basonuclin 1 (BNC1) involved in intrauterine growth restriction (IUGR), and what’s the underlying mechanism? Summary answer BNC1 is significantly decreased placenta of IUGR patients. deficiency engenders Bnc1 truncation mutation (Bnc1tr/tr) mice model by inducing placental necroptosis. What known already among leading causes perinatal morbidity mortality. occurs due to multiple factors, including genetic, placental, fetal, maternal factors. Among which genetic...
Endothelial TRPV4 is a Ca 2+ entry channel critically involved in endothelium‐mediated dilation both conduit and resistance vascular beds. However the importance of this TRPV4‐mediated vasodilation vivo has not been well characterized. We investigated role blood pressure (BP) regulation under normal conditions response to hypertensive challenge. The study was performed TRPV4‐deficient (TRPV4 −/− ) wild‐type (WT) mice implanted with radiotelemetry device for continuous recording mean arterial...
A systematic study of the stability a set cephalosporins in mouse plasma reveals that lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage plasma.
Abstract Recombinant IL-2 has been approved for the treatment of melanoma and renal cancer. However, therapy is limited by its short half-life in circulation associated toxicities that emerge as a result high systemic exposure. To overcome these limitations, we developed localized cytokine LOCOcyteTM platform composed allogeneic engineered cells which produce potent immune effector molecules local delivery with temporal regulation activity. Administration AVB-001 mice non-human primates...
Background Pro-inflammatory cytokines have been approved by the FDA for treatment of metastatic melanoma and renal carcinoma. 1 2 However, effective cytokine therapy is limited its short half-life in circulation severe adverse effects associated with high systemic exposure. 3 To overcome these limitations, we developed a clinically translatable localized delivery platform composed polymer encapsulated epithelial cells that produce natural (IL2, IL7, IL10, or IL12) temporal regulation....