A5040172468- Pregnancy-related medical research
- Atherosclerosis and Cardiovascular Diseases
- Paraoxonase enzyme and polymorphisms
- Cardiovascular Disease and Adiposity
- Occupational Health and Performance
- Diet and metabolism studies
- S100 Proteins and Annexins
- Dietary Effects on Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Single-cell and spatial transcriptomics
- GDF15 and Related Biomarkers
- Vitamin K Research Studies
- Liver Disease Diagnosis and Treatment
- Nitric Oxide and Endothelin Effects
- Asthma and respiratory diseases
- Protease and Inhibitor Mechanisms
- Nutrition, Genetics, and Disease
- Eicosanoids and Hypertension Pharmacology
- Inflammasome and immune disorders
- Gut microbiota and health
La Trobe University
2018-2025
The University of Melbourne
2013-2023
Relaxin is a potent vasodilator of small resistance arteries and modifies arterial compliance in some systemic vascular beds, yet receptors for relaxin, such as RXFP1, have only been localized to smooth muscle. This study first aimed localize RXFP1 rat veins from different organ beds determine whether are present endothelial cells. We then tested the hypothesis that region-specific effects relaxin may be influenced by cellular localization within blood vessels. The aorta, vena cava,...
Abstract The association between constipation and cardiovascular risk is unclear. This population-level matched cohort study compared the of with hypertension incident events in 541,172 hospitalized patients aged ≥ 60 years. For each admission, one exact age-matched non-constipated admission was randomly selected from all hospitalizations within 2 weeks to form comparison cohort. (myocardial infarction, angina, stroke transient ischemic attack) were analysed using a series binary logistic...
Preeclampsia affects up to 8% of pregnancies worldwide and is a leading cause both maternal fetal morbidity mortality. Our current understanding the cause(s) preeclampsia far from complete, lack single reliable animal model that recapitulates all aspects disease further confounds our understanding. This partially due heterogeneous nature disease, coupled with evolving its etiology. Nevertheless, models are still highly relevant useful tools help us better understand pathophysiology specific...
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage unknown. We examined the role of development renal inflammation injury a mouse model low-renin hypertension. Hypertension was induced male C57BL6/J (WT) −/− mice by uninephrectomy, deoxycorticosterone acetate (2.4 mg/d, s.c.) 0.9% drinking saline (1K/DOCA/salt). Normotensive controls received uninephrectomy placebo (1K/placebo). Blood measured via tail cuff or...
Intermittent fasting (IF) is widely recognized for its numerous health benefits, yet impact on metabolic across generations remains relatively unexplored. This study investigates the intergenerational effects of parental IF, specifically through 8-hour daily time-restricted feeding, offspring. By examining four different combinations mating groups, we demonstrate that IF can influence offspring in distinct ways. Our results reveal conferred significant advantages compared to ad libitum (AL)...
Perivascular adipose tissue (PVAT) expansion promotes inflammation and vascular dysfunction in metabolic syndrome (MetS), but the sexual dimorphisms of PVAT are poorly understood. Using a new mouse model diet-induced MetS, we characterized aorta determined influence on function males females. Six-week-old C57BL/6 mice were fed either high-fat diet (43% kcal food) with high sugar salt their drinking water (10% fructose corn syrup 0.9% NaCl; HFSS), or normal chow (NCD) for 10 weeks. The was at...
Background: Aortic stiffening is a consequence of hypertension and major contributor to end organ damage. A key driver aortic fibrosis involving the excess production extracellular matrix (ECM) proteins such as collagen, fibronectin laminin. The present study aimed identify cell types signalling mechanisms that contribute in hypertension. Methods Results: Male C57BL/6 mice (10-12-week-old) were randomly assigned 28-day angiotensin II (0.7 mg/kg/day) or vehicle (saline) infusion via osmotic...
Background A recent clinical trial ( RELAX in Acute Heart Failure [ ‐ AHF ]) demonstrated that 48 hours of continuous intravenous infusion the vasorelaxant peptide serelaxin (recombinant human relaxin‐2) to patients with acute heart failure reduced cardiovascular mortality at 180 days. The persistence a response as potential mechanism for this long‐term benefit and vascular effects bolus injection have not been examined. This study investigates changes resistance artery reactivity passive...
The vascular effects of exogenous relaxin (Rln) treatment are well established and include decreased myogenic reactivity enhanced relaxation responses to vasodilators in small resistance arteries. These reduced older animals, suggesting that Rln is less effective mediating arterial function with aging. present study investigated the role endogenous aorta possibility dysfunction occurs more rapidly aging Rln-deficient (Rln(-/-)) mice. We compared underlying vasodilatory pathways male...
In the RELAX-AHF trial, a 48 h i.v. serelaxin infusion reduced systemic vascular resistance in patients with acute heart failure. Consistent preclinical studies, augments endothelial vasodilator function rat mesenteric arteries. Little is known about contribution of endothelium-derived relaxing factors after longer duration continuous treatment. Here we have assessed reactivity and mechanistic pathways arteries veins aorta or 72 serelaxin.Male rats were infused either placebo (13.3 μg·kg(-1)...
The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that play an important role in the regulation inflammatory processes. It is well-established activation FPRs can have cardioprotective properties. Recently, more stable small-molecule FPR1/2 agonists been described, including both Compound 17b (Cmpd17b) and 43 (Cmpd43). Both activate range signals downstream human-engineered FPR-expressing cells, ERK1/2 Akt. Importantly, Cmpd17b (but not Cmpd43) favours bias...
This study aimed to examine the association of blood triglyceride levels with fasting glucose and type 2 diabetes (T2D) prevalence in Chinese adults normal (<1.7 mmol/L), using linear regression binary logistic regression, respectively. cross-sectional included 16,706 adults, among which 1,067 had T2D. Triglycerides were positively associated plasma after multivariate adjustment (β=0.034, P<0.001). One natural log unit increase triglycerides was a 61% higher...
The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous treatment reduces myogenic reactivity through nitric oxide (NO)-mediated vasorelaxation and increases arterial compliance in small resistance arteries. However, less is known about roles of relaxin, particularly males. Therefore, we used male wild-type (Rln+/+) knockout (Rln-/-) mice to test hypothesis that passive wall properties mesenteric arteries would be compromised Rln-/- mice. Passive was...
Background and Purpose Endothelium‐derived vasoconstriction is a hallmark of vascular dysfunction in hypertension. In some cases, an overproduction endothelium‐derived prostacyclin (PGI 2 ) can cause contraction rather than relaxation. Relaxin well known for its vasoprotective actions, but the possibility that this peptide could also reverse has never been investigated. We tested hypothesis short‐term relaxin treatment mitigates spontaneously hypertensive rats (SHR). Experimental Approach...
Obesity and vascular dysfunction are independent sexually dimorphic risk factors for cardiovascular disease. A high fat diet (HFD) is often used to model obesity in mice, but the sex-specific effects of this on aortic inflammation function unclear. Therefore, we characterized immune cell profile 6-week-old male female C57BL/6 mice fed a normal chow (NCD) or HFD 10 weeks. Metabolic parameters were measured weekly fortnightly. At end point, populations endothelial using flow cytometry wire...