A5060167908- Bariatric Surgery and Outcomes
- Gestational Diabetes Research and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gout, Hyperuricemia, Uric Acid
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Cancer Research and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Pregnancy and preeclampsia studies
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Retinoids in leukemia and cellular processes
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Renal cell carcinoma treatment
- Alcohol Consumption and Health Effects
- Cancer, Lipids, and Metabolism
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
Deakin University
2019-2024
Ballarat Health Services
2019-2022
South Australia Pathology
2019-2020
The University of Melbourne
2020
Peninsula Health
2020
Soochow University
2019
University of British Columbia Hospital
2015
This study aimed to examine the association of blood triglyceride levels with fasting glucose and type 2 diabetes (T2D) prevalence in Chinese adults normal (<1.7 mmol/L), using linear regression binary logistic regression, respectively. cross-sectional included 16,706 adults, among which 1,067 had T2D. Triglycerides were positively associated plasma after multivariate adjustment (β=0.034, P<0.001). One natural log unit increase triglycerides was a 61% higher...
Helicobacter pylori infection occurs in more than half of the world's population and is main cause for gastric cancer. A series lifestyle nutritional factors, such as tobacco smoking obesity, have been found to elevate risk cancer development. In this study, we sought determine immunological aspects during H. We that B cells from pylori-infected patients presented altered composition function compared uninfected patients. IL-10-expressing CD24+CD38+ were upregulated patients, contained...
Abstract Aim Current International Association of the Diabetes and Pregnancy Study Groups/World Health Organization gestational diabetes mellitus (GDM) diagnostic thresholds are based on a landmark study in which pre‐analytical plasma glucose sampling methodology is unclear. Worldwide, practices divergent. We considered effects GDM prevalence outcomes. Methods This retrospective observational cohort 1178 pregnant women undergoing an oral tolerance test (OGTT). Of women, subset 892 non‐GDM...
Chloride intracellular channel protein 4 (CLIC4) has been implicated in different types of cancers, but the role CLIC4 development gastric cancer (GC) remains unknown. We analyzed expression 102 pairs adenocarcinomas by western blot and real-time PCR. Our data revealed that is reduced GC tumor tissues compared with adjacent normal tissues. The levels correlate inversely clinical stage GC. lowest MKN45 cells, which have highest tumorigenic potential express stem cell markers CD44 OCT4, N87...
This study aimed to investigate whether both high and low levels of low-density lipoprotein cholesterol (LDL-C), i.e., hypercholesterolemia hypocholesterolemia, were associated with diabetes in Chinese adults. cross-sectional included 22,557 The LDL-C reference interval was determined from a healthy sub-cohort. Associations between hypocholesterolemia or analyzed using binary logistic regression. 1.48–3.77 mmol/L (57.23–145.78 mg/dL). Therefore, normocholesterolemia, defined as an...
Background: We investigated the treatment effects of tight glycaemic targets in a population universally screened according to International Association Diabetes and Pregnant Study Groups (IADPSG)/World Health Organisation (WHO) gestational diabetes mellitus (GDM) guidelines. As yet there, have been no randomized control trials evaluating effectiveness mild GDM diagnosed under IADPSG/WHO diagnostic thresholds. hypothesize that pregnant women with will result similar clinical outcomes just...
Sunitinib is a tyrosine kinase inhibitor that frequently used in the treatment of metastatic renal cell carcinoma (mRCC). As multikinase inhibitor, numerous off-target side effects this medication are widely recognized. More recently, endocrine effects, including hypoadrenalism, becoming more apparent. We report case which 71-year-old female experienced recurrent adrenal crises when managed with sunitinib for mRCC on background immune-related hypopituitarism and hypoadrenalism as result...
Abstract Purpose: Imetelstat is a first-in-class, lipidated 13-mer oligonucleotide thio-phosphoramidate telomerase inhibitor with anti-tumor activity. It currently in Phase II clinical development. Its distribution tissues, specifically tumor and bone marrow, was studied xenograft mouse model established using human OVCAR-5 cell line. Data from the study indicated imetelstat marrow concentrations were sustained during terminal phase. This suggests further of will be important order to...
Abstract Background We investigated the treatment effects of tight glycaemic targets in a population universally screened according to International Association Diabetes and Pregnant Study Groups/World Health Organisation gestational diabetes mellitus (GDM) guidelines. Methods A multiple cut-off regression discontinuity study design retrospective observational cohort undergoing oral glucose tolerance tests (n = 1178). Treatment GDM women with targets: fasting ≤ 5.0 mmol/L 2-hour...