A5023445380- Pregnancy-related medical research
- Nitric Oxide and Endothelin Effects
- Additive Manufacturing and 3D Printing Technologies
- Paraoxonase enzyme and polymorphisms
- Heart Rate Variability and Autonomic Control
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pregnancy and preeclampsia studies
- Eicosanoids and Hypertension Pharmacology
- 3D Printing in Biomedical Research
- S100 Proteins and Annexins
- Phytochemicals and Antioxidant Activities
- Occupational Health and Performance
- Cardiovascular Health and Disease Prevention
- Galectins and Cancer Biology
- Electron Spin Resonance Studies
- Cardiovascular Issues in Pregnancy
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular and exercise physiology
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Function and Risk Factors
- Innovative Teaching Methods
- Protease and Inhibitor Mechanisms
- Pharmacological Effects of Natural Compounds
- Gut microbiota and health
National University of Singapore
2024-2025
Singapore University of Technology and Design
2018-2024
The University of Melbourne
2010-2023
Monash University
2020-2023
RMIT University
2010-2014
Universität Innsbruck
1997
Three-dimensional food printing offers the possibility of modifying structural design, nutrition, and texture food, which may be used for consumers with special dietary requirements such as dysphagic patients. One matrices that can liquid delivery to patients is foams. Foams are widely in different products adjust density, rheological properties, texture. allow stay mouth sufficient time provide hydration while minimizing danger choking. Our work studies foam properties printability both egg...
Orange peels are often discarded as food waste despite being a nutritious source of vitamins and antioxidants. These orange peel wastes (OPW) produced in millions tons globally every year; discarding them results detrimental environmental economical impacts. This paper discusses the application 3D printing technology to effectively upcycle OPW into edible, healthy snacks for consumption. We aimed develop method enable formulate 3D-printable inks direct ink writing (DIW). Using DIW printing,...
Abstract Serelaxin prevents endothelial dysfunction in the mouse aorta ex vivo and inhibits apoptosis cardiomyocytes under acute hyperglycaemia. Less is known about effects of serelaxin an model diabetes. Therefore, we tested hypothesis streptozotocin (STZ)-treated mice that able to reverse diabetes-induced vascular cardiac remodelling. Mice were divided into citrate buffer + placebo, STZ placebo (0.5 mg/kg/d, 2 weeks) groups. After 12 weeks diabetes, sensitivity endothelium-dependent...
Background A recent clinical trial ( RELAX in Acute Heart Failure [ ‐ AHF ]) demonstrated that 48 hours of continuous intravenous infusion the vasorelaxant peptide serelaxin (recombinant human relaxin‐2) to patients with acute heart failure reduced cardiovascular mortality at 180 days. The persistence a response as potential mechanism for this long‐term benefit and vascular effects bolus injection have not been examined. This study investigates changes resistance artery reactivity passive...
The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory properties in various organs, including the kidneys. However, protective effects of context diabetic kidney complications remain controversial. Here, we aimed to evaluate treatment on key markers fibrosis, oxidative stress, inflammation their subsequent impact bile acid metabolism streptozotocin-induced diabetes mouse model.Male mice were randomly allocated placebo-treated control, or relaxin-treated groups (0.5...
In the RELAX-AHF trial, a 48 h i.v. serelaxin infusion reduced systemic vascular resistance in patients with acute heart failure. Consistent preclinical studies, augments endothelial vasodilator function rat mesenteric arteries. Little is known about contribution of endothelium-derived relaxing factors after longer duration continuous treatment. Here we have assessed reactivity and mechanistic pathways arteries veins aorta or 72 serelaxin.Male rats were infused either placebo (13.3 μg·kg(-1)...
Pregnancy is associated with reduced peripheral vascular resistance, underpinned by changes in endothelial and smooth muscle function. Failure of the maternal vasculature to adapt correctly leads serious pregnancy complications, such as preeclampsia. The peptide hormone relaxin regulates renal during pregnancy; however, little known about its effects other beds. This study tested hypothesis that functional adaptation mesenteric uterine arteries will be compromised relaxin-deficient...
The formyl peptide receptor (FPR) family are a group of G-protein coupled receptors that play an important role in the regulation inflammatory processes. It is well-established activation FPRs can have cardioprotective properties. Recently, more stable small-molecule FPR1/2 agonists been described, including both Compound 17b (Cmpd17b) and 43 (Cmpd43). Both activate range signals downstream human-engineered FPR-expressing cells, ERK1/2 Akt. Importantly, Cmpd17b (but not Cmpd43) favours bias...
Abelmoschus esculentus L. Moench (okra) is a commonly consumed vegetable that consists of the seeds and peel component which are rich in polyphenolic compounds. The aim this study to utilize pressurized hot water extraction (PHWE) for bioactive phytochemicals from different parts okra. A single step PHWE was performed at various temperatures (60 °C, 80 100 °C 120 °C) determine temperature exhibits optimum phytochemical profile, antioxidant antidiabetic activities. determined biological...
Abstract The pulp of avocado ( Persea Americana ) is widely consumed as the primary food source, while seed often discarded waste. Increased consumption would inevitably results in production waste by-products such seeds, hence ability to extract phytochemicals from waste, and upcycling potential nutraceutical products great interest. overall aim this study explore seeds functional through combined use a green extraction method, chemical standardization pattern recognition tools, biological...
The mangosteen (Garcinia mangostana L.) pericarp is known to be rich in potent bioactive phytochemical compounds such as xanthones, which possess pharmacologically important antioxidant activity and beneficial cardiometabolic properties. Mangosteen typically classified unavoidable food waste discarded, despite being that therefore present an exciting opportunity for valorization. Thus, this study aims extract from using pressurized hot water extraction (PHWE) determine its biological effects...
The aim of the present study was to examine effect an early stage streptozotocin-induced diabetes on mechanism(s) endothelium-dependent relaxation. Diabetes induced by a single injection streptozotocin (48 mg/kg iv), and ACh-induced relaxation rat carotid arteries examined 6 wk later. A diabetes-induced increase in superoxide levels, determined L-012-induced chemiluminescence, from associated with endothelial nitric oxide (NO) synthase (eNOS) uncoupling increased catalytic subunit NADPH...
The peptide hormone relaxin has striking effects on the vascular system. Specifically, endogenous treatment reduces myogenic reactivity through nitric oxide (NO)-mediated vasorelaxation and increases arterial compliance in small resistance arteries. However, less is known about roles of relaxin, particularly males. Therefore, we used male wild-type (Rln+/+) knockout (Rln-/-) mice to test hypothesis that passive wall properties mesenteric arteries would be compromised Rln-/- mice. Passive was...