Jared Z. Lee

ORCID: 0000-0003-0115-459X
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About
Contact & Profiles
Research Areas
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Cancer Research and Treatments
  • Sarcoma Diagnosis and Treatment
  • Immunotherapy and Immune Responses
  • Neuroblastoma Research and Treatments

Rice University
2021-2022

Proinflammatory cytokines have been approved by the Food and Drug Administration for treatment of metastatic melanoma renal carcinoma. However, effective cytokine therapy requires high-dose infusions that can result in antidrug antibodies and/or systemic side effects limit long-term benefits. To overcome these limitations, we developed a clinically translatable delivery platform composed polymer-encapsulated human ARPE-19 (RPE) cells produce natural cytokines. Tumor-adjacent administration...

10.1126/sciadv.abm1032 article EN cc-by-nc Science Advances 2022-03-02
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