A5103703488- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Parvovirus B19 Infection Studies
- Respiratory and Cough-Related Research
- T-cell and B-cell Immunology
- Entomological Studies and Ecology
- Pharmaceutical studies and practices
- Diabetes and associated disorders
- Congenital Ear and Nasal Anomalies
- Pediatric health and respiratory diseases
- Antifungal resistance and susceptibility
- Simulation Techniques and Applications
- Blood groups and transfusion
- Atmospheric chemistry and aerosols
- Transgenic Plants and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Hemophilia Treatment and Research
- International Student and Expatriate Challenges
- Lymphoma Diagnosis and Treatment
- Information and Cyber Security
- Military Strategy and Technology
- Marine Toxins and Detection Methods
Wake Forest University
2010-2023
Atrium Health Wake Forest Baptist
2014-2021
NOAA Air Resources Laboratory
2014
National Oceanic and Atmospheric Administration
2014
Jackson Laboratory
2003
An inherited disorder makes WAVEs The WAVE regulatory complex (WRC) is a multiunit that regulates actin cytoskeleton formation. Although other actin-regulatory proteins modulate human immune responses, the precise role for WRC has not yet been established. Cook et al. studied five patients from four unrelated families who harbor missense variants of gene encoding component HEM1. These presented with recurrent infections and poor antibody along enhanced allergic autoimmune disorders. HEM1 was...
Ammonia measurements from the Southeastern Aerosol Research and Characterization (SEARCH) study network were analyzed for trends over 9 yr (2004–2012) of observations. Total ammonia concentrations, defined as sum gas-phase fine particle ammonium, found to be decreasing by 1–4% yr−1 qualitatively consistent with emission estimates SEARCH states Alabama, Georgia, Mississippi, Florida. On other hand, mixing ratios slightly rising or steady region, leading observation that fraction total has...
Objective: Timely administration of epinephrine is critical in the treatment anaphylaxis. This study sought to determine frequency by EMS providers caring for pediatric patients prehospital setting. Methods: We examined data from NC database (PreMIS) 2010–3 with studied <18 years age an provider impression "allergic reaction." Anaphylaxis was present if there hypotension (defined as SBP < 90 or DBP 45 11 and older, 70 + (2 × age) ages 0–10), impaired respirations description labored absent...
Abstract: Acquired angioedema is often associated with significant morbidity. An underlying lymphatic malignancy, autoimmune disorder, adenocarcinoma, or other malignancy may be present. Screening for these disorders should occur in all patients acquired as treatment result resolution of angioedema. Keywords: complement, C1-INH deficiency, ecallantide, hemopathy
Abstract Immunodeficiency often coincides with immune hyperresponsiveness such as autoimmunity, lymphoproliferation, or atopy, but the molecular basis of this paradox is typically unknown. We describe four families immunodeficiency coupled cytokine overproduction, hemophagocytic lymphohistocytosis, and autoimmunity. discovered loss-of-function variants in gene NCKAP1L , encoding hematopoietic-specific Hem1 protein. Three mutations cause protein WAVE regulatory complex (WRC) loss, thereby...