Samaneh Delavari
A5014068059- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Cystic Fibrosis Research Advances
- Immune Cell Function and Interaction
- Chronic Lymphocytic Leukemia Research
- Pediatric health and respiratory diseases
- DNA Repair Mechanisms
- Parvovirus B19 Infection Studies
- Blood groups and transfusion
- T-cell and B-cell Immunology
- Pneumocystis jirovecii pneumonia detection and treatment
- Congenital Diaphragmatic Hernia Studies
- Congenital Ear and Nasal Anomalies
- Genomics and Rare Diseases
- Immune responses and vaccinations
- Cytomegalovirus and herpesvirus research
- Carcinogens and Genotoxicity Assessment
- Mycobacterium research and diagnosis
- NF-κB Signaling Pathways
- Occupational and environmental lung diseases
- Genetic factors in colorectal cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Genomic variations and chromosomal abnormalities
- Dietary Effects on Health
Tehran University of Medical Sciences
2018-2025
Children's Medical Center
2018-2025
Universal Scientific Education and Research Network
2021-2025
University of Tehran
2019-2023
Ahvaz Jundishapur University of Medical Sciences
2021
University of Mississippi Medical Center
2020
State Street (United States)
2020
American College of Allergy, Asthma and Immunology
2020
Iran University of Medical Sciences
2020
Jahrom University of Medical Sciences
2018
Abstract Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but real impact this pandemic on pediatric patients with different types primary immunodeficiency (PID) not elucidated. The current prospective study a national registry PID showed only 1.23 folds higher incidence infections, these present 10-folds mortality rate compared to population mainly combined and immune dysregulation. Therefore,...
Inborn errors of immunity (IEIs) are a heterogeneous group genetic defects immunity, which cause high rates morbidity and mortality mainly among children due to infectious non-infectious complications. The IEI burden has been critically underestimated in countries from middle- low-income regions the majority patients with these lack molecular diagnosis.We analyzed clinical, immunologic, data 22 Middle East North Africa (MENA) region. was collected national registries diverse databases such...
Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is instrumental for prevention and treatment in individuals with high risk.
Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the infection leads to hypoxemic pneumonia, although it is much more rare in children.
Abstract Background Ataxia telangiectasia mutated (ATM) kinase plays a critical role in DNA double-strand break (DSB) repair. (A-T) patients exhibit abnormalities immunoglobulin isotype expression and class switch recombination (CSR). This study investigates the of residual ATM activity severity A-T disease. Methods with defined genetic diagnoses were classified based on CSR their medical complications. Isolated peripheral blood mononuclear cells from any patient evaluated before after...
At present, a national consensus or guideline for diagnosing and managing patients suspected of havingpredominantly antibody deficiencies (PADs) is lacking. This written based on combinationof scientific literature comments from the expert panel Iranian immunologists. A group clinicalimmunologists reviewed current consensus, presented their at meeting titled 'First Meetingon Diagnosis Inborn Errors Immunity (IEI) by IEI Experts,' agreed this consensus. Thisconsensus provides recommendations...
Currently, a national consensus or guideline for diagnosing and managing patients suspected of having chronic granulomatous disease (CGD) is lacking. This written based on combination scien- tific literature comments from the expert panel Iranian immunologists. A group clinical immunol- ogists reviewed current consensus, presented their at meeting titled “First Meeting Diagnosis Inborn Errors Immunity (IEI) by IEI Experts” agreed this consensus. provides recommendations diagnosis,...
Background: Inborn errors of immunity (IEI) include immunodeficiencies affecting cellular and humoral immunity. Objectives: We aimed to compare the effectiveness LTT carboxyfluorescein succinimidyl ester (CFSE) assays in assessing lymphocyte proliferation IEI patients. Methods: utilized radioactive [3H]-thymidine non-radioactive CFSE measure three distinct groups: syndromic CID (SyCID), non-syndromic combined immunodeficiency (N-SyCID), primary antibody deficiency (PAD). Results: identified...
Background and Aims Janus kinase-3 (JAK3) deficiency, first described in 1995, is an autosomal recessive inborn error of immunity that mostly results variants severe combined immunodeficiency (SCID). The frequency estimated to account for 7-14% heritable SCID, with sporadic cases the Western world. Neither preferential “hot spots” nor founder effects have yet been documented. Hereby, we aim describe global experience JAK3-related diseases regarding clinical spectrum, genetic landscape,...
Monogenic immune dysregulation diseases (MIDD) are caused by defective immunotolerance. This study was designed to increase knowledge on the prevalence and spectrum of MIDDs, genetic patterns, outcomes in Middle East North Africa (MENA). MIDD patients from 11 MENA countries (Iran, Turkey, Kuwait, Oman, Algeria, Egypt, United Arab Emirates, Tunisia, Jordan, Qatar, Azerbaijan) were retrospectively evaluated. 343 (58% males 42% female) at a median (IQR) age 101 (42-192) months enrolled. The...
DCLRE1C gene mutation leads to Artemis deficiency, a severe form of combined immunodeficiency (SCID). Impaired DNA repair and block in early adaptive immunity maturation results T-B-NK+ associated with radiosensitivity. Recurrent infections life are the main characteristic patients.Among 5373 registered patients, 9 Iranian patients (33.3% female) confirmed were identified since 1999-2022. The demographic, clinical, immunological genetic features collected through retrospective investigation...
Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate class switch recombination (CSR) and review clinical immunologic phenotypes 3 groups A-T patients, including patients CSR defects (CSR-D), selective immunoglobulin A deficiency...
Abstract Purpose Primary B cell defects manifesting as predominantly antibody deficiencies result from variable inborn errors of the lineage and their development, including impairments in early bone marrow class switch recombination (CSR), or terminal differentiation. In this study, we aimed to investigate autoimmunity monogenic patients with development differentiation defects. Methods Patients known genetic were recruited Iranian immunity registry. Results A total 393 a defect (257 males;...
<b><i>Background:</i></b> Common variable immunodeficiency (CVID) is the most frequent primary disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction B cells and decreased immunoglobulin levels. In this study, our aim to evaluate clinical, immunological, molecular data patients with a clinical diagnosis CVID autoimmune phenotype confirmed genetic diagnosis....
Selective IgA deficiency (SIgAD) is the most prevalent inborn errors of immunity with almost unknown etiology. This study aimed to investigate clinical diagnostic and prognostic values lymphocyte subsets function in symptomatic SIgAD patients.A total 30 available patients from Iranian registry age-sex-matched healthy controls were included present study. We analyzed B T cell peripheral proliferation assay by flow cytometry mild severe phenotypes.Our results indicated a significant increase...
Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently defined combined primary immunodeficiency disease (PID) characterized by recurrent respiratory tract infections, lymphoproliferation, autoimmunity and lymphoma. Gain-of-function mutations in PIK3CD loss-of-function of PIK3R1 genes lead to APDS1 APDS2, respectively.Demographic, clinical, immunological genetic data were collected from medical records 15 pediatric patients, who genetically identified using the whole-exome...
Background.Primary immunodeficiency diseases (PIDs) are life-threatening disorders, which manifest commonly with gastrointestinal (GI) signs, mainly as chronic diarrhea. Objective. To investigate and compare infectious etiology of diarrhea in different PIDs. Patients methods. Assessing clinical features, obtaining immunological profiles, well characterizing were performed 38 PID patients Stool samples and/or biopsy specimens checked using culture, microscopic examination, RT-PCR, PCR,...
Abstract Background Ataxia‐telangiectasia (A‐T) is a rare genetic disorder characterized by distinct range of clinical manifestations, including progressive ataxia, immunodeficiency, and radiosensitivity. Methods Clinical data, laboratory results, data were collected from forty‐three A‐T patients. Whole‐exome sequencing Sanger done for the patients clinically diagnosed as suffering A‐T. Based on phenotype severity disease, divided into severe mild subgroups. Results The median (IQR) age...
The inborn errors of immunity (IEIs) are a group heterogeneous disorders mainly characterized by severe and recurrent infections besides other complications including autoimmune inflammatory diseases. In this study, we aim to evaluate clinical, immunologic, molecular data monogenic IEI patients with without manifestations.We have retrospectively screened cases in the Iranian PID registry for occurrence autoimmunity immune dysregulation. A questionnaire was filled all qualified defects...