A5029619155- DNA Repair Mechanisms
- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Hemoglobinopathies and Related Disorders
- Thyroid Cancer Diagnosis and Treatment
- Prenatal Screening and Diagnostics
- Genomics and Rare Diseases
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- BRCA gene mutations in cancer
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Congenital heart defects research
- MicroRNA in disease regulation
- Thyroid Disorders and Treatments
- Nutrition, Genetics, and Disease
- Metabolism and Genetic Disorders
- Ethics and Legal Issues in Pediatric Healthcare
- Demographic Trends and Gender Preferences
- Cancer-related molecular mechanisms research
- Laser Applications in Dentistry and Medicine
- Genetics and Neurodevelopmental Disorders
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Cancer Genomics and Diagnostics
Kharazmi University
2025
Tehran University of Medical Sciences
2014-2024
Imam Khomeini Hospital
2009
Shariati Hospital
2003-2007
University of Tehran
2007
Queen's Medical Centre
2001-2005
University of Nottingham
2001-2005
Cervical cancer is a human papilloma virus (HPV)-related cancer, but most HPV infections are transient or intermittent and resolve spontaneously. Thus, other factors, such as cervical microflora, which dominated by lactobacilli, must be involved in invasive carcinoma development after infection. Previous studies have demonstrated that lactobacilli antitumour effects, it possible vaginal prevent cancer. Here we examined the proliferative apoptotic responses of normal tumour cells to common...
We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ counts at birth persisted over time, normal memory and high γδ counts. Their TCRα repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue development. Only a minority of these individuals were sick, infection, lymphoproliferation, and/or autoimmunity. also report 1 in 4000 from the Middle East South...
Summary. Consanguineous marriage has had considerable attention as a causative factor in the prevalence of genetic disorders. Iran, with its majority Muslim population, high rate consanguineous marriage. In Iranian tradition, first cousin is an acceptable and appreciated custom. However, there seems to be no encouragement Islamic context; it merely mentioned traditional common This paper may help medical professionals providing premarital counselling, who are regularly asked about marriage,...
Germ-line mutations of RET proto-oncogene are the known cause hereditary medullary thyroid carcinoma (MTC), which account for approximately 25% all MTC cases and occur as multiple endocrine neoplasia type 2 syndromes. Here, we present first comprehensive genetic screening analysis among Iranian families.A total 55 patients with (male to female ratio=1:1.6; average age disease onset = 33 ± 13 years) from 53 independent families participated in this study. All had undergone thyroidectomy...
Objectives: The aim of this study was to compare ultrasonography with CT scan and submentovertex films in the visualization zygomatic arch fractures. Methods: 17 patients, 10 men 7 women, suspected fracture were studied. data from plain compared ultrasonographic findings (Aloka 3500 (Tokyo, Japan) ultrasound equipment a 7.5 MHz transducer). probe situated over fractured transversely evaluate its whole length. All sonograms taken interpreted by same sonologist, who not aware results films....
Objectives: Ataxia-telangiectasia (A-T) is an autosomal recessive neurodegenerative disorder with multisystem involvement caused by homozygous or compound heterozygous mutations in the ataxia telangiectasia mutated (ATM) gene which encodes a serine/threonine protein kinase. The aims of this study were to investigate class switch recombination (CSR) and review clinical immunologic phenotypes 3 groups A-T patients, including patients CSR defects (CSR-D), selective immunoglobulin A deficiency...
Hypoxanthine phosphoribosyltransferase (HPRT1), as a salvage pathway enzyme, plays crucial role in modulating the cell cycle and has been reported to be overexpressed multiple cancers. Nevertheless, relationship between HPRT1 gene head neck squamous carcinomas (HNSCCs) not investigated so far. In this study, we first evaluated expression clinical value of mRNA protein tumor healthy control tissues. Then, examined mutations their association with survival outcomes patients HNSCC. We also...
Background: Peroxisome proliferator-activated receptor γ2 (PPARγ2) is a nuclear that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. The aim of this study was to investigate the association between Pro12Ala single nucleotide polymorphism (SNP) at PPARγ2 gene type II diabetes (T2DM) obesity in an Iranian population. Methods: genomic DNA 312 subjects included four groups: (1) nonobese with diabetes, (2) obese without (3) (4) nondiabetic controls. detected by...
Carnitine is a key molecule in energy metabolism that helps transport activated fatty acids into the mitochondria. Its homeostasis achieved through oral intake, renal reabsorption and de novo biosynthesis. Unlike dietary intake reabsorption, importance of biosynthesis pathway carnitine remains unclear, due to lack animal models description single patient defective this pathway. We identified by array comparative genomic hybridization 42 months-old girl homozygote for 221 Kb interstitial...
Abstract Population based genetic counseling that promotes public health goals is an appropriate care service. The center in Shiraz, southern Iran serves most of the clients region. During a 4‐year period, 2,686 couples presented for counseling. Data files revealed 85% had consanguineous relationships (1.5% double first cousin, 74% 8% second 1.5% beyond cousin). Most prevalent reasons referral were premarital (80%), with 89% consanguinity, followed by preconception (12%), postnatal (7%), and...