A5045520017- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Sperm and Testicular Function
- Cancer, Lipids, and Metabolism
- Fatty Acid Research and Health
- Liver Disease Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Helicobacter pylori-related gastroenterology studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Drug Transport and Resistance Mechanisms
- Enzyme Catalysis and Immobilization
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nanoparticle-Based Drug Delivery
- Cardiac Ischemia and Reperfusion
- Monoclonal and Polyclonal Antibodies Research
- Lysosomal Storage Disorders Research
- Alzheimer's disease research and treatments
- Electrohydrodynamics and Fluid Dynamics
- Electrochemical sensors and biosensors
- Computational Drug Discovery Methods
- Cell Adhesion Molecules Research
- Paraoxonase enzyme and polymorphisms
Tehran University of Medical Sciences
2010-2019
Imam Khomeini Hospital
2009
University of Tehran
2004-2009
Islamic Azad University, Shahr-e-Qods Branch
2008
The lipid composition of the sperm membrane has been shown to exert a significant effect upon functional quality spermatozoa. We have studied fatty acid phospholipids in spermatozoa asthenozoospermic and normozoospermic men determined ratio polyunsaturated acids (PUFAs) saturated these two groups. Fatty concentration was 15 eight semen samples by thin layer chromatography gas chromatography. most abundant were docosahexaenoic (DHA 22 : 6 ω3, 98.5 ± 4.5 nmol per 108 spermatozoa, mean SE)...
Codelivery of chemo-sensitizers with chemotherapeutics using combo nanomedicine is a promising platform for overcoming chemoresistance in breast cancer. However, tumor accumulation nano-carriers based on enhanced permeability and retention (EPR) effect confounded by heterogeneity microenvironment. Adsorption protein corona surface nanoparticle boost up clearance reticulo-endothelial system. In this study, functionalized magnetic nanocomposite (NC) codelivery doxorubicin (DOX) curcumin (CUR)...
It is well-established that nonalcoholic fatty liver disease (NAFLD) associated with type 2 diabetes mellitus (T2DM). Complement-C1q TNF-related protein 5 (CTRP5) a novel adipokine involved in the regulation of lipid and glucose metabolism. We aimed to assess plasma levels CTRP5 patients NAFLD (n = 22), T2DM 22) (NAFLD + T2DM) comparison healthy subjects 21) also study association between diabetes-related parameters. All underwent anthropometric assessment, biochemical evaluation stiffness...
Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common diseases. It robustly linked to obesity and insulin resistance regarded hepatic manifestation metabolic syndrome (MetS). Adipokines are involved in pathophysiology The aim this study was evaluate plasma concentrations CTRP1 (complement-C1q TNF-related protein 1) 22 patients with NAFLD, type 2 diabetes mellitus (T2DM), NAFLD+T2DM 21 healthy controls, well their correlation level parameters. Plasma concentration...
ATP‐binding cassette transporter A1 (ABCA1) is a key mediator of cholesterol efflux to apoA‐I in lipid‐loaded macrophages, which the first step reverse transport vivo and critical preventing atherosclerosis. Enhanced ABCA1 expression may inhibit foam cell formation consequently reduce atherogenic risk. The purpose this study was investigate effect S‐allylcysteine (SAC), most abundant organosulfur compound aged garlic extract, on human THP‐1 macrophages. monocyte cells were differentiated...
Background: Peroxisome proliferator-activated receptor γ2 (PPARγ2) is a nuclear that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity. The aim of this study was to investigate the association between Pro12Ala single nucleotide polymorphism (SNP) at PPARγ2 gene type II diabetes (T2DM) obesity in an Iranian population. Methods: genomic DNA 312 subjects included four groups: (1) nonobese with diabetes, (2) obese without (3) (4) nondiabetic controls. detected by...
It is evident that coronary artery disease (CAD) closely associated with abnormal glucose and lipid metabolism. Notably, dysregulation of inflammatory pathways immune system also contribute to CAD development. Recently, it has been suggested visfatin, a proinflammatory adipocytokine, may be involved in several metabolic diseases. In this study, we evaluated the serum visfatin levels its mRNA expression peripheral blood mononuclear cells (PBMCs) from patients compared control subjects. We...
ABSTRACT The purpose of this study was to determine major factors impacting the size simvastatin (SIM)‐loaded poly( d , l ‐lactic‐ co ‐glycolide) (PLGA) nanoparticles (NPs) that prepared using electrospraying. Three variables including concentration polymer and salt as well solvent flow rate were used input variables. Size NPs considered output variable. For first time, our findings a systematic experimental approach, showed importance dominant factor determining with sharp reverse effect....
Transformation of macrophages to foam cells is determined by the rates cholesterol uptake and efflux. This study uses a real time RT-PCR technique investigate role conjugated linoleic acid (CLA), α-linolenic (ALA) eicosapentaenoic (EPA) in regulation ATP-binding cassette A1 (ABCA1) liver X receptor α (LXR) genes, which are involved homeostasis. Accordingly, these fatty acids significantly reduced total, free esterified cholesterols within cells. While expression ABCA1 LXRα genes was...
Abstract Background Experimental studies indicate that gamma linolenic acid (GLA) and docosahexaenoic (DHA) may inhibit glioma cells growth but effects of oral consumption these fatty acids on brain tumor composition have not been determined in vivo. Methods GLA oil (GLAO; 72% GLA), DHA (DHAO; 73% DHA) were fed to adult wistar rats (1 mL/rat/day) starting one week prior C6 implantation continued for two weeks after implantation. Control group same amount high linoleic safflower (74–77%...
Abstract Background One of the most important factors in initiation and progression atherosclerosis is default macrophage cholesterol homeostasis. Many genes transcription such as Peroxisome Proliferators Activated Receptors (PPARs) Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) are involved Fatty Acids ligands PPARα concentration them can effect expression ACAT1. So this study designed to clarified on role these fatty acids lipid metabolism foam cells. Methods This examined effects...
Abstract One of the major issues in cell therapy myocardial infarction (MI) is early death engrafted cells a harsh oxidative stress environment, which limits potential therapeutic utility this strategy clinical setting. Increasing evidence implicates beneficial effects omega‐3 fatty acids including eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) ascorbic (AA) cardiovascular diseases, particular their role ameliorating fibrosis. In current study, we aim to assess cytoprotective EPA +...