A5006555477- Ovarian function and disorders
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Lipid metabolism and disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Reproductive System and Pregnancy
- Adipose Tissue and Metabolism
- Lipid metabolism and biosynthesis
- COVID-19 Clinical Research Studies
- Calcium signaling and nucleotide metabolism
- Apelin-related biomedical research
- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Amino Acid Enzymes and Metabolism
- Lysosomal Storage Disorders Research
- Biomarkers in Disease Mechanisms
- Birth, Development, and Health
- Ovarian cancer diagnosis and treatment
- Advanced Glycation End Products research
- Cholesterol and Lipid Metabolism
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Connective Tissue Growth Factor Research
- Organ Transplantation Techniques and Outcomes
University of Tehran
2018-2024
Tehran University of Medical Sciences
2011-2024
Hamedan University of Medical Sciences
2011-2016
Abstract Background Insulin resistance has a vital role in the pathophysiology of polycystic ovary syndrome (PCOS). Previous investigations have shown that some lipid ratios could be simple clinical indicator insulin (IR) disorders and ethnicities. The present study was conducted to evaluate correlation between triglyceride HDL-cholesterol (TG/HDL-C), total cholesterol (TC/HDL-C), as well fasting triglyceride-glucose (TyG) indices with IR (as measured by homeostasis model assessment...
Abstract Background and aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is a global metabolic problem which can lead to irreversible fibrosis. It has been shown that vitamin D its receptors contribute fibrogenic pathways in the liver. However, effect of supplementation on fibrosis related factors have not examined. This double blinded placebo controlled clinical trial was designed investigate effects serum levels VDR, MicroRNAs MASLD patients. Methods Forty six patients...
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting females reproductive age. It has been associated with cardiometabolic including diabetes mellitus and cardiovascular disorders, increases risk developing fecundity pathologies recurrent pregnancy loss (RPL) infertility. C1q/tumor necrosis factor-α-related protein-6 (CTRP6) a novel adipokine involved in glucose lipid metabolism, host inflammation, organogenesis. In present study, we aimed to determine...
Coronary artery disease (CAD) is considered as a multi-faceted chronic inflammatory involving reduced blood supply to the myocardium result of accumulating lipids in atrial walls. Visceral adiposity with disrupted release adipokines play key role its pathogenesis. Asprosin newly identified fasting-induced glucogenic adipokine that has been related metabolic disorders such type II diabetes mellitus and polycystic ovary syndrome. The preset study sought assess circulating asprosin context...
C1q TNF related protein 3 (CTRP3) is an adipokine secreted from adipose tissue. Previous studies have suggested that CTRP3 improves insulin sensitivity and reduces inflammation. Human evaluated circulating levels of this in patients with diabetes mellitus (DM), diabetic retinopathy, metabolic syndrome, coronary artery diseases. However, nephropathy not been evaluated. The present study aimed to assess serum type 2 (T2DM) (T2DM-NP) its relationship inflammatory markers.This cross-sectional...
Patients diagnosed with polycystic ovary syndrome (PCOS) are at high risk of developing a myriad endocrinologic and metabolic derailments. Moreover, PCOS is leading cause habitual abortion, also known as recurrent pregnancy loss (RPL). Meteorin-like protein (Metrnl) newly discovered adipokine the potential to counteract metaflammation. This study aimed determining associations serum Metrnl levels homocysteine, hs-CRP, some components in PCOS-RPL infertile patients.This case-control was...
Lipid ratios and the triglyceride glucose index (TyG) could be a simple biochemical marker of insulin resistance (IR). The current study was carried out to examine correlation between high-density lipoprotein-cholesterol (TG/HDL-C), total cholesterol HDL-C (TC/HDL-C), low-density ratio (LDL-C/HDL-C), as well TyG with severity mortality severe coronavirus disease 2019 (COVID-19). A 1228 confirmed COVID-19 patients were included in research. Regression models performed evaluate lipid COVID-19....
Altered production of adipokines is suggested to play a pivotal role in the pathogenesis polycystic ovarian syndrome (PCOS). C1q/TNF-related proteins (CTRPs) diverse roles regulation metabolism physiologic and pathologic conditions. In present study, we assessed serum concentrations adiponectin, CTRP12, CTRP13 individuals with PCOS those without PCOS. We also evaluated possible association these metabolic hormonal variables. A total 171 premenopausal women (86 85 PCOS) enrolled this study....
It is evident that coronary artery disease (CAD) closely associated with abnormal glucose and lipid metabolism. Notably, dysregulation of inflammatory pathways immune system also contribute to CAD development. Recently, it has been suggested visfatin, a proinflammatory adipocytokine, may be involved in several metabolic diseases. In this study, we evaluated the serum visfatin levels its mRNA expression peripheral blood mononuclear cells (PBMCs) from patients compared control subjects. We...
Background Adipokine leptin plays a crucial role in metabolic and reproductive functions. Leptin receptor has soluble form that binds to leptin, thus modulating its level the circulation. It been indicated levels of also LEP rs7799039 LEPR rs1137101 polymorphisms are associated with disorders. In present study, we assessed (sOB-R), frequency healthy fertile women patients polycystic ovary syndrome (PCOS), inclusive PCOS-infertile PCOS-recurrent pregnancy loss (RPL) subjects. Methods A total...
Paraoxonase1 (PON1) is a glycoprotein associated with high density lipoprotein and has antioxidant activity. The impact of PON1 in various stages spermatogenesis also been suggested. This study was aimed to investigate frequencies phenotypes Q192R genotypes fertile infertile males. variants were determined 150 men using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) technique. Plasma arylesterase paraoxonase activities detected by spectrophotometry...
This study investigates the relationship between sperm DNA damage in recurrent implantation failure (RIF) patients treated with comparative genomic hybridisation array-intracytoplasmic injection (CGH array-ICSI) cycles and embryo aneuploidy screening. Forty-two RIF couples were selected. Sperm DFI was measured using TUNEL by flow cytometry. Two groups defined as follows: (i) high (> 20%); (ii) low (< 20%). Semen parameters, total antioxidant capacity (TAC), malondialdehyde formation (MDA)...
Lipid components of spermatozoa have an important role in the functional activity this cell. The protein, apolipoprotein E (apoE), has a central lipid transport. aim study was to investigate distribution APOE genotypes, ϵ3ϵ3, ϵ3ϵ4, and ϵ2ϵ3, corresponding alleles fertile infertile males, assess semen parameters from patients carrying different alleles. In addition, levels cholesterol, phospholipid, triacylglycerol spermatozoa, isolated by PureSperm gradient seminal plasma samples males...