A5080874380- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Natural Antidiabetic Agents Studies
- Liver physiology and pathology
- Biochemical effects in animals
- Sperm and Testicular Function
- Hippo pathway signaling and YAP/TAZ
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Paraoxonase enzyme and polymorphisms
- Adipokines, Inflammation, and Metabolic Diseases
- Apelin-related biomedical research
- Reproductive System and Pregnancy
- Drug-Induced Hepatotoxicity and Protection
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Liver Diseases and Immunity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Curcumin's Biomedical Applications
- Antioxidant Activity and Oxidative Stress
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
Hamedan University of Medical Sciences
2016-2025
Tufts University
2019
Jean Mayer Human Nutrition Research Center on Aging
2019
University of Miami
2019
Kashan University of Medical Sciences
2019
Islamic Azad University, Karaj
2016
Heidelberg University
2013
Chronic low-grade inflammation has been suggested as a key contributor of the pathogenesis and development polycystic ovary syndrome (PCOS). To investigate association between oxidative stress status inflammatory cytokines in follicular fluid 21 PCOS women compared to with normal ovarian function who underwent intra-cytoplasmic sperm injection. Concentration IL-6, IL-8, IL-10, TNF-α was measured using sandwich ELISA. Oxidative examined by measuring total oxidant (TOS), malondialdehyde (MDA),...
Background: Millions of people in the world have diabetes mellitus and its prevalence is growing. Oxidative stress, advanced glycation end-products (AGEs) receptor for (RAGE) play key role pathogenesis diabetes. New safe strategies remedy are needed this disease. Objectives: We hypothesized that resveratrol may exert a renal protective effect on diabetic rats. Materials Methods: Male rats with were treated or without as 1, 5, 10 mg/kg body weight 30 days. The total AGEs malondialdehyde...
Incidence of diabetes mellitus is dramatically growing in the world. Oxidative stress, advanced glycation end products (AGEs) and receptor for AGE (RAGE) play key role pathogenesis diabetes. Little known about resveratrol effects on liver. We hypothesize that may exert a hepatoprotective effect diabetic rats. Male rats with were treated or without at 1, 5 10 mg/kg body weight 30 days. Total AGEs malondialdehyde (MDA) levels liver tissues determined by spectrofluorimetric methods. antioxidant...
Oxidative stress has been known for having a key role in pathogenesis of many diseases. The aim this study was to investigate the oxidative and also relationship between antioxidant system statuses lung function patients with COPD smokers non-smokers subjects.Thirty subjects COPD, 30 smokers, healthy participated study. investigation included determination measurements plasma ceruloplasmin, ferritin, total capacity, erythrocyte glutathione peroxidase, reductase, superoxide dismutase,...
Methylglyoxal (MG), the major dicarbonyl substrate of enzyme glyoxalase 1 (GLO1), is a reactive metabolite formed via glycolytic flux. Decreased GLO1 activity in situ has been shown to result an accumulation MG and increased formation advanced glycation endproducts, both which can accumulate during physiological aging at accelerated rate diabetes other chronic degenerative diseases. To determine consequences from elevated levels role aging, wound healing young (≤12 weeks) old (≥52 wild-type...
Abstract Changes in the cellular microenvironment play a critical role development of bladder cancer (BC). Yes‐associated protein (YAP), central mediator Hippo pathway, functions as nuclear sensor mechanotransduction that can be induced by stiffness extracellular matrix (ECM), including resulting from surgical manipulations. We aimed to clarify possible association between surgically‐related ECM and YAP activation BC patients. compared 30 tissues with grade II ( n = 15 recurrent newly...
Although the majority of patients with diabetes have disorders in sexual function, associations between mellitus and sperm function at molecular level are largely unknown. As receptor for advanced glycation end products plays a key role many diabetic complications, we hypothesised that it may be involved nuclear DNA fragmentation. RAGE levels were determined using ELISA western blot analysis samples from 32 35 nondiabetic men. Sperm fragmentation was assessed TUNEL assay. Diabetic men had...
The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane that overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE breast cancer tumors still not completely clear.In this study, we investigated levels 25 fresh-frozen samples and corresponding noncancerous tissue collected from patients, by real-time polymerase chain reaction (PCR). Additionally, performed immunohistochemistry on specimens.The results...
It is believed that matrix metalloproteinases (MMPs) play important roles in follicular development and pathogenesis of polycystic ovary syndrome (PCOS). However, conflicting results are available about the alteration MMP2 MMP9 concentrations or activities PCOS. In fact, there no study entirely investigating both concentration activity these MMPs serum levels their tissue inhibitors TIMP2 TIMP1, as well lipocalin-bound form (MMP9/NGAL). Therefore, thoroughness previous studies questionable....
Objective: Little is known about the exact underlying molecular mechanisms of hepatoprotective effect carvacrol against liver fibrosis. In current study, we aimed to investigate on suppression fibrosis progression via regulation yes-associated protein (YAP) and transcriptional coactivators with a PDZ-binding motif (TAZ) transforming growth factor beta (TGF-β) pathway.Materials methods: To fulfill our target, rats received carbon tetrachloride (CCl4) intraperitoneally, orally, respectively...
In this study, we have investigated whether silymarin intake influences lipid and glycogen content in conjunction with sirtuin1 (SIRT1) sterol regulatory element-binding protein 1c (SREBP-1c) expressions liver of type 2 diabetic rat.Thirty-six male Wistar rats were randomly divided into six groups: control groups (C) (D); the received 60 or 120 mg/kg (C+S60 C+S120), (D+S60 D+S120) daily for 8 weeks. Serum biochemical parameters, as well glycogen, oxidative stress biomarkers, tissue measured...
The anticancer activity of triamterene on HCT116 and CT26 colon cancer cells lines was investigated. Furthermore, the mechanism interaction between calf thymus DNA (ct-DNA) also human serum albumin (HSA) conducted using spectroscopic molecular docking techniques. In vitro cytotoxicity against showed promising effects with IC50 values 31.30 24.45 μM, respectively. Competitive studies NR (neutral red) MB (methylene blue) as intercalator probes that can be replaced by these probes. viscosity...
Since activation of NLRP3 inflammasome results in the production interleukin-1β (IL 1β) and initiation inflammation as key players development cancer, this study investigated possible during progression colorectal cancer (CRC) evaluated role epithelial-mesenchymal transition (EMT) process.Tissue samples were collected from cancerous (test) adjacent normal tissues (control) forty-three male CRC patients (18 grade I 25 III). The gene expression protein levels determined by qRT PCR Western...
The active ingredients of traditional medical herbs have been the focus scientific interests.This study was designed to explore mechanisms actions parthenolide on nonalcoholic fatty liver disease (NAFLD).Thirty-five male Wistar rats were fed high-fat diet (HFD) for eight weeks with or without an intraperitoneal injection develop NAFLD. Liver triacylglycerol (TG), total antioxidant capacity (TAC), oxidative status (TOS), thiobarbituric acid reactant substances (TBARs), thiol groups and tumor...
Ovarian cancer is one of the important challenges in field gynecologic oncology because some problems understanding its etiology and pathogenesis. Receptor for advanced glycation end products (RAGE) a multiligand trans-membranous receptor which upregulated human cancers. Mechanisms RAGE involvement carcinogenesis ovarian are unknown.This study aimed to investigate expression cancers association with clinicopathological characteristics.The level corresponding noncancerous tissues were...
Introduction: Hyperglycemia enhances oxidative stress and apoptosis induces damages in heart tissue. Based on antioxidant properties of curcumin metformin, we hypothesized that these agents may exhibit cardioprotective effects by attenuating modulating expression the genes involved type-1 diabetes. Methods: Thirty-six male rats were randomly divided into six groups; (N): control; (D): streptozotocin-induced diabetic rats; (D+Cur50) (D+Cur150): treated with 50 150 milligram per kilogram body...