Abstract Changes in the cellular microenvironment play a critical role development of bladder cancer (BC). Yes‐associated protein (YAP), central mediator Hippo pathway, functions as nuclear sensor mechanotransduction that can be induced by stiffness extracellular matrix (ECM), including resulting from surgical manipulations. We aimed to clarify possible association between surgically‐related ECM and YAP activation BC patients. compared 30 tissues with grade II ( n = 15 recurrent newly...

(2008). Genomic diversity of Blastocystis hominis from patients in southern Iran. Annals Tropical Medicine & Parasitology: Vol. 102, No. 1, pp. 85-88.

Sperm DNA damage is one of the associated factors idiopathic male infertility and abnormal spermatogenesis. This study was conducted to assess possible association between risk with X-ray repair cross complementing group 1 (XRCC1) Arg399Gln (G A) ligase 4 (LIG4) Thr9Ile (C T) gene polymorphisms which are involved in different pathways. In this case-control 191 fertile infertile men (29-40 years old) were enrolled. The single-nucleotide polymorphism genotypes alleles XRCC1 LIG4 assessed using...

Percutaneous nephrolithotomy (PCNL) is the recommended first-line treatment for staghorn stones. To achieve complete stone clearance, PCNL may require using multiple tracts.To evaluate outcome of in patients with calculi and its correlation number tracts features.One hundred consecutive renal who underwent were included study. Perioperative postoperative features recorded. Correlation variables size was assessed.Mean age (± SD) 49.6 ± 14.7 years. Our ASA class I. The mean cumulative burden...

Background: Ammonia, urea, uric acid, and creatinine are the major non-protein nitrogenous compounds (NPNs). It is reported that concentration of NPNs in seminal plasma normal infertile individuals different sperm affected by NPNs. Objectives: The aim this study was to determine quantities ammonia, correlation these with fertilization rate after an intracytoplasmic injection (ICSI). Methods: levels were determined collected from 50 men. ammonia urea L-glutamate dehydrogenase diacetyl...

Introduction and Aim: Multiple sclerosis (MS) is a complex neurological condition might emerge as result ofcomplex combination of genetic risk factors with environmental triggers, including oxidative stress. in this study we aimed to evaluate the effects oral Crocin on stress patients MS. 
 Materials Methods: Adjunct standard treatment, group (20 patients) received 30-mg/day (15 mg twice daily) dose placebo for 4 weeks. Saliva urine samples were collected determine levels total...

The purpose of this study is to investigate the molecular mechanism underlying hepatoprotective effect Chlorella vulgaris extract (CVE). administration both doses CVE attenuated liver damage and decreased serum markers oxidative stress parameters dramatically. Also, treatment downregulated hepatic gene expression collagen type1 (Col1a1), fibronectin (Fn1), transforming growth factor-beta 1 (Tgfb1), receptor 2 (Tgfbr2) SMAD family member 3 (Smad3) significantly. Hepatic level TGF-β1 protein...

Resveratrol is a polyphenol that found in plants and has been proposed to have potential therapeutic effect through the activation of SIRT1, which crucial member mammalian NAD+ -dependent deacetylases. However, how its activity enhanced toward specific substrates by resveratrol derivatives not studied. This study aimed evaluate types interaction with SIRT1 as target protein, well find out best ligand strangest SIRT1.

Background: Urinary tract stones are one of the most common causes kidney disease. There is evidence for possible involvement oxidative stress in formation and renal cell injury. Objectives: In this study, we aimed to determine total antioxidant capacity (TAC), malondialdehyde (MDA), serum thiol group, ceruloplasmin (CP) levels catalase (CAT) activity patients with stones. Materials Methods: This study was conducted as a case-control study. A 31 (16 males 15 females) stone(s) comparative...

This study was aimed to evaluate the protective effects of Chlorella Vulgaris (CVE) (50 and 100 mg/kg doses) on sperm DNA fragmentation, testis oxidative stress in Carbon tetrachloride (CCL4)-exposed rats. Thirty healthy male Wistar rats were divided into five groups (n = 6): Control; CCl4; CVE; CCl4 + CVE50; CVE100. At end experiment, testicular parameters estimated. The Chromomycin A3 (CMA3) Acridine orange (AO) staining performed examine fragmentation status. treatment showed a...

Background: Elevated serum level of adiponectin and insulin decreased resistin can improve glucose metabolism. Biochanin A (BCA) is a flavonoid Soybean that shows antioxidant properties. This study was aimed to examine the effect BCA on FBS, oxidative stress levels adiponectin, in rats with type 1 diabetes.Material method: The were randomly divided into five groups (n=6). administered orally doses 10 15 mg/kg body weight. Insulin, measured using ELISA kits. activity Gamma-Glutamyltransferase...

This study was aimed to investigate the effect of microalgae Chlorella vulgaris (C. vulgaris) on nonalcoholic fatty liver disease (NAFLD)-related complications induced by high-fat diet (HFD). Fifty adult male rats were divided into six groups. Control group and HFD treated with or without C. 5% 10%. Biochemical parameters in serum measured spectrophotometric enzyme-linked immunosorbent assay (ELISA) methods. The relative gene expression levels Tumor Necrosis Factor-alpha (TNF-α), NF-kappa B...

Objective: Improving productivity is one of the most important strategies for social-economic development. Human resources are known as in organizations' survival and success. Aims: To determine factors affecting human resource using ACHIEVEa model from nurses' perspective then prioritize them head nurses Analytic Hierarchy Process (AHP) technique. Settings Design: Iran, Shiraz University Medical Sciences teaching hospitals 2012. Materials Methods: This was an applied, cross-sectional...

Aluminum phosphide (AlP) as an effective pesticide may contribute to oxidative stress and adversely influence sperm parameters. This study aimed investigate the protective role of curcumin nanocurcumin on damage in testis rats with AlP toxicity.A total 42 adult male Wistar were equally randomized into following groups (n = 7): Control, Control+Curcumin, Control+Nanocurcumin, AlP, AlP+Curcumin, AlP+Nanocurcumin. The tissue was used levels testicular malondialdehyde (MDA), oxidant status...

Natural treatment of cancer has received a lot attention recently due to its advantages including low cost, and fewer side effects. In this study, we aimed investigate the antimetastatic properties Cyrtopodion scabrum, common home gecko, through Epithelial-Mesenchymal Transition (EMT) process.Human colon HCT116 cell line was selected allocated into following experimental groups: untreated control, vehicle control (DMSO), Retinoic acid (RA), two groups aqueous C.scabrum Whole Extract (CWE)...

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women childbearing age. As a complex structure, extracellular matrix (ECM) and its components, including glycosaminoglycans (GAGs) collagens, are highly affected by hormonal alterations. Objectives: This study aimed to evaluate level GAG hydroxyproline follicular fluid (FF) with PCOS. Methods: Overall, 62 referring Fatemieh Hospital Infertility Center Hamadan were evaluated this study. FF samples taken...