A5056703999- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Endometrial and Cervical Cancer Treatments
- Immune Response and Inflammation
- Mesenchymal stem cell research
- Reproductive Physiology in Livestock
- Macrophage Migration Inhibitory Factor
- Estrogen and related hormone effects
- Renal and related cancers
- Ovarian cancer diagnosis and treatment
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Reproductive Health and Technologies
- Uterine Myomas and Treatments
- Pregnancy-related medical research
- Gynecological conditions and treatments
- Neonatal Respiratory Health Research
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Cardiovascular Issues in Pregnancy
- Immunotherapy and Immune Responses
Royan Institute
2016-2025
Academic Center for Education, Culture and Research
2015-2024
Institut de Médecine de la Reproduction
2022
Iran University of Medical Sciences
2009-2021
Tehran University of Medical Sciences
2012
University of Sheffield
2006-2009
Jessop Hospital
2009
Universidad de Murcia
2007
The notion of a gamete recognition system that alerts females to the presence gametes in their reproductive tract profoundly influences our understanding physiology events leading conception and bearing offspring. Here, we show female responds within her by modulating environment which pregnancy is initially established. We found distinct alterations oviductal gene expression as result sperm oocyte arrival oviduct, led directly composition fluid vivo. This suggests either activates...
Investigating the mechanisms of human primordial germ cell (PGC) and gamete development are important for understanding causes infertility effects environmental chemicals on reproductive development. However, there practical ethical difficulties associated with obtaining tissue in early The aim this study was to investigate whether embryonic stem cell-hESC-generated cells could provide an vitro model development.Human ESCs were differentiated as embryoid bodies (EBs) vitro. Gene protein...
Developing wisdom teeth are easy-accessible source of stem cells during the adulthood which could be obtained by routine orthodontic treatments. Human pulp-derived (hDPSCs) possess high proliferation potential with multi-lineage differentiation capacity compare to ordinary adult cells(1-8); therefore, hDPSCs good candidates for autologous transplantation in tissue engineering and regenerative medicine. Along these benefits, possessing mesenchymal (MSC) features, such as immunolodulatory...
Abstract Background Nowadays, the number of cancer survivors is significantly increasing as a result efficient chemo/radio therapeutic treatments. Female may suffer from decreased fertility. In this regard, different fertility preservation techniques were developed. Artificial ovary one these methods suggested by several scientific groups. Decellularized ovarian cortex has been introduced scaffold in field human preservation. This study was carried out to compare decellularization various...
Abstract Background Melatonin, as a free radical scavenger exhibiting genomic actions, regulates the antioxidant genes expression and apoptosis mechanisms. In polycystic ovary syndrome (PCOS) patients, an imbalance between radicals antioxidants in follicular fluid leads to oxidative stress, aberrant folliculogenesis, intrinsic defects PCOS oocytes. this experimental mouse model study, oocytes of control groups were cultured different melatonin concentrations (10 − 5 , 10 6 7 M) investigate...
Background: Studies have shown that embryonic stem cells can differentiate into germ either spontaneously or directed by the defined factors applying a co-culture method conditioned medium of stromal cells. Objective: Here, Yazd4 (human [hESC] line; 46, XX) was used to evaluate effect human cumulus (CCCM) on in vitro cell production and development. Materials Methods: In this experimental study 2 different complete media were applied, Dulbecco’s modified eagle’s + 20% fetal bovin serum...
We evaluated gene expression of estrogen and progesterone nuclear receptors in granulosa cells (GCs) polycystic ovary syndrome (PCOS) women compared to with normal cycling ovaries (control group) achieve a better understanding ovarian steroid status patients PCOS. In this prospective study, 40 PCOS ovulatory function who underwent vitro fertilization (IVF) for treatment tubal and/or male infertility were recruited. Follicular fluid was collected from GCs isolated follicular then purified...
The purpose of oocyte in vitro maturation is generation mature oocytes that could support future development. Efforts have been made to enhance developmental competence by developing optimal culture conditions. present study conducted determine melatonin effects on quality polycystic ovarian syndrome (PCOS) when it has added during maturation, and immature were cultured defined conditioned medium with without different concentrations. Melatonin significantly improve nuclear PCOS (81.1% vs....
Developing wisdom teeth are easy-accessible source of stem cells during the adulthood which could be obtained by routine orthodontic treatments. Human pulp-derived (hDPSCs) possess high proliferation potential with multi-lineage differentiation capacity compare to ordinary adult cells1-8; therefore, hDPSCs good candidates for autologous transplantation in tissue engineering and regenerative medicine. Along these benefits, possessing mesenchymal (MSC) features, such as immunolodulatory...
Sperm function can be affected by infection. Our understanding of innate immune system molecular mechanisms has been expanded, the discovery 'Toll-like receptors' (TLRs). It seems that these receptors could play a critical role in protection spermatozoa. This study seeks to examine presence and distribution TLRs different parts human male reproductive tract So, TLR gene expression was examined RT-PCR. Quantitative real-time PCR (Q-PCR) analysis used compare all sections 2, 3 4 testicular...
Toll like receptors (TLRs) are one of the main components innate im- mune system. It has been reported that expression these altered in female reproductive tract (FRT) during menstrual cycle. Here we used a fallopian tube epithelial cell line (OE-E6/E7) to evaluate effect two sex hormones modulating TLR expression.In this experimental study, initially gene OE- E6/E7 cells was evaluated and compared with tissue using quanti- tative real time-polymerase chain reaction (qRT-PCR) immunostaining....