A5102025926- Reproductive Biology and Fertility
- Ovarian function and disorders
- Reproductive System and Pregnancy
- Cholesterol and Lipid Metabolism
- Facial Nerve Paralysis Treatment and Research
- Renal and related cancers
- Circadian rhythm and melatonin
- Head and Neck Surgical Oncology
- Vascular anomalies and interventions
- Meningioma and schwannoma management
- Trace Elements in Health
- Dialysis and Renal Disease Management
- Sperm and Testicular Function
- Renal and Vascular Pathologies
- Endometriosis Research and Treatment
- Birth, Development, and Health
Tehran University of Medical Sciences
2003-2025
Shariati Hospital
2021
Abstract Objective The present study aimed to elucidate how mesenchymal stem cells (MSCs) application could efficiently attenuate pathological changes of letrozole-induced poly cystic ovary syndrome (PCOS) by modulating mitochondrial dynamic via PI3K-AKT pathway. Methods Thirty-two female rats were randomly divided into four experimental groups: Sham, PCOS, PCOS + MSCs, and MSCs LY294002. Sham group received 0.5% w/v carboxymethyl cellulose (CMC); the letrozole (1 mg/kg, daily) in CMC for 21...
Abstract Background Melatonin, as a free radical scavenger exhibiting genomic actions, regulates the antioxidant genes expression and apoptosis mechanisms. In polycystic ovary syndrome (PCOS) patients, an imbalance between radicals antioxidants in follicular fluid leads to oxidative stress, aberrant folliculogenesis, intrinsic defects PCOS oocytes. this experimental mouse model study, oocytes of control groups were cultured different melatonin concentrations (10 − 5 , 10 6 7 M) investigate...
Salvia.officinalis (S. officinalis), is recognized for its antihyperlipidemic, metabolism-regulating, and antioxidant properties in diabetic hyperlipidemic disorders. This study examining effects on lipid oxidative stress (OS) markers patients with Polycystic Ovary Syndrome (PCOS), thereby substantiating role managing metabolic In this randomized placebo-controlled trial was performed gynecology clinics affiliated to Iran University of Medical Sciences. Accordingly, 70 Iranian married women...
Astaxanthin (ASX) is a lipid-soluble keto-carotenoid with several biological effects. These effects may benefit polycystic ovarian syndrome (PCOS) patients. Imbalanced apoptosis/anti-apoptosis signaling has been considered the major pathogenesis of PCOS. In randomized clinical trial, we tested impact ASX on apoptotic pathway in PCOS granulosa cells (GCs). The present study hypothesizes that improve apoptosis
Poor ovarian response (POR) to controlled stimulation (COS) remains challenging, especially in advanced-age women with diminished reserve, resulting low live birth rates. Many patients prefer conceive their eggs, underscoring the need for improved treatments. This study explores astaxanthin potential as a COS adjuvant improve and assisted reproductive technology (ART) outcomes, considering its impact on oxidative stress (OS), inflammation, apoptosis, which are key factors POR.