Mahnaz Ashrafi

ORCID: 0000-0002-7278-8509
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About
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Research Areas
  • Reproductive Biology and Fertility
  • Ovarian function and disorders
  • Reproductive System and Pregnancy
  • Endometriosis Research and Treatment
  • Health and Well-being Studies
  • Macrophage Migration Inhibitory Factor
  • Cardiovascular Disease and Adiposity
  • Pregnancy and Medication Impact
  • Ovarian cancer diagnosis and treatment
  • Sperm and Testicular Function
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Demographic Trends and Gender Preferences
  • Reproductive Health and Technologies
  • Reproductive Physiology in Livestock
  • Liver Disease Diagnosis and Treatment
  • Immunodeficiency and Autoimmune Disorders
  • Adipose Tissue and Metabolism
  • Adipokines, Inflammation, and Metabolic Diseases
  • Gynecological conditions and treatments

Iran University of Medical Sciences
2014-2025

Royan Institute
2014-2015

Academic Center for Education, Culture and Research
2015

Abstract Objective To evaluate the efficacy of a microfluidic culture system supplemented with follicular fluid meiosis‐activating sterol (FF‐MAS) on maturation immature oocytes in patients polycystic ovarian syndrome (PCOS). Methods A total 438 germinal vesicle from 163 PCOS were included. Oocytes divided into five groups: (1) cultured static drops without FF‐MAS, (2) (3) device (4) FF‐MAS for first 2 h, and (5) 24 h. Maturation, fertilization, embryo development rates assessed, alongside...

10.1111/jog.16203 article EN Journal of Obstetrics and Gynaecology Research 2025-01-01

Background: Progesterone levels are critical for endometrial receptivity and implantation success in assisted reproductive technology (ART). The purpose of the current study was to determine whether serum progesterone on oocyte retrieval day predict pregnancy fresh embryo transfers. Methods: This cross-sectional conducted at a university-affiliated infertility clinic Tehran, Iran, 2024. Blood samples were collected analyze estradiol (E2), (P4), follicle-stimulating hormone (FSH), luteinizing...

10.18502/jri.v25i4.18125 article EN Journal of Reproduction & Infertility 2025-03-11

We evaluated gene expression of estrogen and progesterone nuclear receptors in granulosa cells (GCs) polycystic ovary syndrome (PCOS) women compared to with normal cycling ovaries (control group) achieve a better understanding ovarian steroid status patients PCOS. In this prospective study, 40 PCOS ovulatory function who underwent vitro fertilization (IVF) for treatment tubal and/or male infertility were recruited. Follicular fluid was collected from GCs isolated follicular then purified...

10.3109/09513590.2014.1001733 article EN Gynecological Endocrinology 2015-01-21

Women with polycystic ovary syndrome have lower pregnancy rates, possibly due to the decreased uterine receptivity. Successful implantation depends on protein networks that are essential for cross-talk between embryo and endometrium. Apolipoprotein A1 has been proposed as a putative anti-implantation factor. In this study, we evaluated apolipoprotein expression in human endometrial tissues.Endometrial messenger RNA (mRNA) were investigated using quantitative real-time polymerase chain...

10.4103/1735-1995.172813 article EN cc-by-nc-sa Journal of Research in Medical Sciences 2015-01-01

Endometrial receptivity and implantation are important topics in reproductive sciences. No evidence was found to support sperm involvement endometrial its associated factors. This study aimed explore the effect of normal human spermatozoa–endometrium cell interaction regulating genes pathway. Semen samples were collected from a healthy fertile man; then, they incubated with cells for 24 hr considered as group. A group cultured without spermatozoa control About later, bottom culture dish. The...

10.1111/and.14077 article EN Andrologia 2021-04-28
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