A5009390097- Advanced Radiotherapy Techniques
- Cancer survivorship and care
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiation Therapy and Dosimetry
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- FOXO transcription factor regulation
- Circadian rhythm and melatonin
- Radiation Dose and Imaging
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Thyroid Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Neuroblastoma Research and Treatments
- Curcumin's Biomedical Applications
- Chemotherapy-related skin toxicity
- Meningioma and schwannoma management
Hamedan University of Medical Sciences
2014-2024
Cancer Research Center
2012-2024
Hamedan University of Technology
2015
Mashhad University of Medical Sciences
2012
Ionizing radiation (IR) is widely used in the treatment of cancer radiotherapy. One main concerns patients with gastrointestinal cancers undergoing radiotherapy harmful side effects IR on normal tissues. The liver, kidney, and duodenum are usually exposed to high doses some abdominal region We aimed assess radioprotective Malva sylvestris L. against damages region.This current study was conducted 45 rats divided randomly into nine groups five: A) negative control group, B) sham C)...
Fatigue associated with malignant conditions and their treatments is a disabling condition. This trial assessed the anti-fatigue effects of melatonin coadministration during adjuvant treatment patients breast cancer.Patients cancer were randomly assigned to receive or placebo chemotherapy radiotherapy. Thirty-seven enrolled in each group. The mean ages intervention control groups 50.47 ± 10.79 46.05 10.55 years, respectively (P = .223). group received oral (18 mg/day) from 1 week before...
Objective: Cancer related fatigue is a distressing condition and correlated with decrease in quality of life patients malignant conditions. In continuation our previous research, we assessed long term anti-fatigue effects melatonin the breast cancer. Material methods: this clinical trial, 92 cancer were randomly assigned to receive either (18 mg/day) or placebo from 1 week before adjuvant treatments until 2 years after their completion. The levels intervention using Brief Fatigue Inventory...
Abstract Abnormal expression of various microRNAs (miRNAs), as regulators biological signaling pathways, has a strong association with cancer resistance to chemotherapy and radiotherapy. The let‐7 family miRNAs tumor suppressors have shown be downregulated in different types human malignancies including colorectal (CRC). However, the function members processes radiation CRC not yet been completely elucidated. Insulin‐like growth factor 1 receptor (IGF‐1R) pathway is amplified leads its...
Usually, chemoradiotherapy can be used for the treatment of locally advanced colorectal cancer (CRC) before surgery. On other hand, some studies have shown that fractional radiation tumor cells leads to chemoresistance. The aim this study was evaluate chemoresistance radioresistant sub-line (RR sub-line).This done in Hamadan University Medical Sciences 2017-2018. MTT assay and sub-G1 fraction analysis by flow cytometry were cross-resistance RR gefitinib regorafenib. Real-time PCR investigate...
Side effects of severe weight loss during radiation therapy and its definitive risk factors are the significant complexities cancer treatment. This study aimed to identify reliable predictors three-dimensional conformal (3D-CRT) in head neck patients. Weight changes radiotherapy were investigated on 87 Tumor site, T-stage, BMI, age, smoking, treatment modality, prior surgery considered as effective factors. During 3D-CRT, 78.7% patients experienced (p<0.001). The was higher with larynx oral...
As a rare entity, sarcomas of the head and neck are challenging cases. In this paper, we represent unique case Ewing sarcoma mandible, serving as an example multidisciplinary team importance in developing country.
Background: Glioblastoma multiform (GBM) is a highly aggressive tumor with median survival of approximately 14 months. Management consists maximal surgical resection followed by post-operative chemoradiation concurrent then adjuvant temozolamide. The standard radiotherapy dose 60Gy in 2-Gy fractions recommended the radiation therapy oncology group (RTOG). With vast majority recurrences occurring within previous irradiation field and poor outcome associated therapy, regimens designed to...
Colorectal cancer (CRC) is one of the most prevalent diagnosed cancers and a common cause cancer-related mortality. Despite effective clinical responses, large proportion patients undergo resistance to radiation therapy. Therefore, identification efficient targeted therapy strategies would be beneficial overcome radioresistance. Doublecortin-like kinase 1 (DCLK1) an intestinal pancreatic stem cell marker that showed overexpression in variety cancers. The transfection
Some compounds have been investigated to mitigate the effect of radiation on lung, such as pneumonitis and fibrosis. This study aimed examine mitigation efficiency Spirulina compared Metformin. 25 male Wistar rats were allotted in five groups: control, Spirulina, Radiation, Radiation plus Rat chest regions irradiated by 15 Gray (Gy) xradiation using aLINAC. Forty-eight hours after irradiation, treatment with Metformin began. Eighty days all sacrificed, their lung tissues removed for...
Effects of Melatonin on IL-6 Serum Level Changes and Fatigue Caused by Adjuvant Chemoradiotherapy in Breast Cancer Women: A Randomized Controlled Trial
Shielding design is necessary for brachytherapy treatment room in order to protect the general public and employees. The main objective of this study was investigate whether protective unit our Brachytherapy Centre provided adequate protection health safety assessment radiobiological impact. In study, we estimated effect from a single Ir-192 source center by using MCNP5 Monte Carlo measurements. based on specifications HDR 192 Ir modeled. dose rate range buildings (0.45 - 0.64): (micro...
Background: Erectile dysfunction (ED) is a common side effect of prostate cancer treatment, affecting up to 50% patients after radiation therapy. Objectives: This study aims analyze the correlation between dose received by penile bulb (PB) and ED in men who underwent definitive therapy for early-stage without androgen deprivation Methods: The included 40 3D conformal (3D-CRT) localized were reported be potent before as determined International Index Function (IIEF-15) questionnaire. PB was...
Objectives: Chemotherapy-induced peripheral neuropathy (CIPN) is a significant clinical issue that affects patients’ quality of life and can limit the dosing chemotherapeutic agents. N-acetylcysteine (NAC) has been proposed as potential chemoprotective agent against CIPN due to its antioxidant properties. This study aimed investigate efficacy oral NAC in preventing controlling taxane-induced patients with breast cancer. Methods: randomized, triple-blind, placebo-controlled trial included 80...
The use of small fields has increased by the emergence advanced radiotherapy. Dose calculations these are complex and challenging for many reasons such as lack electrical equilibrium even in homogeneous environments, this complexity will increase presence heterogeneity. According to importance delivery accurate prescription dose target volume patient's body, calculation accuracy used commercial algorithms clinical treatment planning systems (TPS) should be evaluated.The present study aims...
Abstract Purpose: To develop a multiple logistic regression model as normal tissue complication probability by least absolute shrinkage and selection operator (LASSO) technique in breast cancer patients treated with three-dimensional conformal radiation therapy (3D-CRT), we focused on the changes of pulmonary function tests to achieve optimal predictive parameters for occurrence symptomatic pneumonitis (SRP). Materials methods: Dosimetric spirometry data 60 were analyzed. Pulmonary done...
Comparison of Random Survival Forests for Competing Risks and Regression Models in Determining Mortality Risk Factors Breast Cancer Patients Mahdieh Center, Hamedan, Iran