The systemic administration of cytotoxic chemotherapeutic agents for cancer treatment often has toxic side effects, limiting the usage dose. To increase efficacy while reducing a rational design synergy-based drug regimens is essential. This study investigated augmentation therapeutic effectiveness with co-administration paclitaxel (PTX; an effective breast cancer) and curcumin (CUR; chemosensitizer) in MCF-7 cell line.We optimized niosome formulations terms surfactant cholesterol content....

In this study, a highly porous three-dimensional (3D)-printed wound healing core/shell scaffold fabricated using poly-lactic acid (PLA). The core of was composed hyaluronic (HA), copper carbon dots (Cu-CDs), rosmarinic acid, and chitosan hydrogel. Cu-CDs were synthesized ammonium hydrogen citrate under hydrothermal conditions. Formulation containing 1 mg ml-1 concentration showed an excellent antibacterial activity against gram bacteria. At 0.25 concentration, had good biocompatibility as...

Bladder cancer is one of the concerning urological malignant diseases in world, which has a clinical need for effective targeted therapy. The development nanotechnology-based gene delivery to bladder tumor sites an strategy therapy with low/no toxicity. With this view, present work, mesoporous silica nanoparticles (MSNs) modified c(RGDfK)-PLGA-PEG [c(RGDfK)-MSN NPs] were constructed co-delivery miR-34a and siPD-L1 within cells tissues. Our findings showed that downregulated while PD-L1...

Abstract Cisplatin is one of the conventional drugs used in chemotherapy which has a potent antitumor function. However, due to dangerous side effects, including damage DNA normal cells, its clinical use limited. The aim this study was prepare and characterize nanoliposome containing cisplatin. We optimized liposome formulations through modification proportion SPC80 (soybeanphospholipids with 75% phosphatidylcholine) cholesterol content. Then, novel PEGylated liposomal SPC80: cholesterol:...

Aims: Achieving an effective biocompatible system for siRNAs delivery to the tumor site remains a significant challenge. Materials & methods: Selenium nanoparticles (SeNPs) modified by chitosan (CS) and hyaluronic acid (HA) were fabricated PLK1 (siPLK1) bladder cancer cells. The HA-CS-SeNP@siPLK1 efficacy was evaluated using in vitro vivo models. Results: selectively internalized into T24 cells through clathrin-mediated endocytosis. Treatment with successfully silenced gene, inhibited cell...

Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by the accumulation of fat in without excessive alcohol consumption. Lifestyle modifications, such as adopting healthy diet, represent standard treatment for NAFLD. However, impact Dietary Approaches to Stop Hypertension (DASH) diet on oxidative stress biomarkers patients with NAFLD remains unclear. Therefore, this study aimed determine effect DASH total antioxidant capacity (TAC), catalase (CAT), superoxide dismutase...

This study investigated the effect of resveratrol on serum and cardiac levels angiotensin II transcription its main receptors following pressure overload induced-hypertrophy. Rats were divided into untreated (Hyp) treated hypertrophied groups (H + R). Intact animals served as control (Ctl). Cardiac hypertrophy was induced by abdominal aortic banding. Blood (BP) recorded via left carotid artery cannula. Fibrosis confirmed Masson trichrome staining. Angiotensin level measured using an ELIZA...

Introduction. The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has been shown to be associated with a number complications type 2 diabetes. Results on development and progression albuminuria, however, have remained controversial, ethnic differences being potential reason.The present study is first report examine Iranian patients. Methods. Patients (322; 162 males) diabetes were categorised in this cross-sectional into following groups:...

Abstract Cancer treatment is challenging due to late-stage diagnosis, drug resistance and systemic toxicity of chemotherapeutic agents. The formulation the into nanoparticles (NPs) can enhance efficacy effectiveness. Therefore, a new cationic niosomal formulation, which contains Tween 80, 60, cholesterol lysine amino acid as platform model transfection reach more acceptable stability, curcumin (Cur) biological anti-cancer drug, are introduced. Here, authors focused on design synthesis novel...

Transformation of macrophages to foam cells is determined by the rates cholesterol uptake and efflux. This study uses a real time RT-PCR technique investigate role conjugated linoleic acid (CLA), α-linolenic (ALA) eicosapentaenoic (EPA) in regulation ATP-binding cassette A1 (ABCA1) liver X receptor α (LXR) genes, which are involved homeostasis. Accordingly, these fatty acids significantly reduced total, free esterified cholesterols within cells. While expression ABCA1 LXRα genes was...

Background: Osteoporosis (OP) is one of the most prevalent metabolic bone diseases at higher ages, especially in postmenopausal women.Objective: To determine effect consumption garlic tablet on proteins oxidation biomarkers osteoporotic women.Methods: The present study was a double-blind randomized controlled clinical trial that included 42 women Yazd during 2014-2015.Osteoporotic were randomly assigned into two groups: group (GG) and placebo (PG).Participants GG took tablets daily for 1...

Abstract Background One of the most important factors in initiation and progression atherosclerosis is default macrophage cholesterol homeostasis. Many genes transcription such as Peroxisome Proliferators Activated Receptors (PPARs) Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) are involved Fatty Acids ligands PPARα concentration them can effect expression ACAT1. So this study designed to clarified on role these fatty acids lipid metabolism foam cells. Methods This examined effects...

Background: Breast cancer (BC) is a complex disease, but current treatments are not efficient enough considering increased relapse and decreased survival rate among patients. Poly (ADP-ribose) polymerase inhibitors recently developed anticancer agents which target cells with defects in homologous recombination (HR) pathway. This study wishes to assess whether the combination of AZD2461 as newly PARP1 inhibitor valproic acid (VPA), histone deacetylase could effectively reduce growth MCF-7 no...

Prostate cancer (Pca) is a heterogeneous disease, and current treatments are not based on molecular stratification. Poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors have recently been found to be remarkably toxic cells with defects in homologous recombination, particularly BRCA-mutated backgrounds. Therefore, this preliminary study was designed evaluate whether PTEN expression status could an impact the sensitivity of invasive Pca PARP inhibitor, AZD2461.MTT viability...

Both canola and sesame oils consumption have been associated with favorable effects on cardio-metabolic biomarkers. However, to the best of our knowledge, no study has compared their cardiovascular risk factors. The present aimed assess effect canola, sesame, sesame-canola biomarkers in patients type 2 diabetes mellitus (T2DM).

Recently, concerns about arsenic have been increased due to its high acute toxicity human and serious environmental problems. In this study, the ability of Halorcula sp. IRU1, a novel halophilic archaea isolated from Urmia lake, Iran for bioaccumulation was investigated optimized by Taguchi experimental design. The optimum conditions Haloarcula IRU1 could be achieved in presence temperature 40oC, pH 8 NaAsO 2 at 90 mg/L. Under conditions, microorganism able perform their desired function...

The study aimed at measuring exhaled breath malondialdehyde (EBC-MDA) in workers exposed to dust containing silica and its comparison with the non-exposed control group.The cross sectional, case-control (N = 50) was performed a tile ceramics production factory Yazd, Iran. EBC-MDA quantified of participants by lab made sampler. Exposure intensity measured according NIOSH 0600 method selected homogeneous exposure groups. Additionally, spirometry test conducted investigate correlation between...