A5019251600- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Esophagitis
- Respiratory and Cough-Related Research
- Contact Dermatitis and Allergies
- Urticaria and Related Conditions
- Pediatric health and respiratory diseases
- Adsorption and biosorption for pollutant removal
- Streptococcal Infections and Treatments
- Inhalation and Respiratory Drug Delivery
- Adrenal Hormones and Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thyroid Disorders and Treatments
- Metabolism and Genetic Disorders
- Healthcare and Venom Research
- Hematological disorders and diagnostics
- Child Nutrition and Feeding Issues
- Phytase and its Applications
- Pharmaceutical studies and practices
- Folate and B Vitamins Research
- Bartonella species infections research
Karamanoğlu Mehmetbey University
2023-2024
Ondokuz Mayıs University
2023-2024
Kilis 7 Aralık University
2013-2024
Istinye University
2019-2022
Kocaeli Üniversitesi
2022
Gazi University
2004-2019
Şişli Etfal Eğitim ve Araştırma Hastanesi
2016-2019
Van Yüzüncü Yıl Üniversitesi
2018
Ministry of Health
2009-2017
Ankara Atatürk Göğüs Hastalıkları Ve Göğüs Cerrahisi Eğitim Ve Araştırma Hastanesi
2017
Despite drug-related hypersensitivity reactions are an important health problem, epidemiologic data on drug allergy and limited, studies including diagnostic work-up scarce. The aim of this study was to determine the actual frequency immediate type using tests in school children with parent-reported allergies.This involved three phases. first phase is a survey mean age 12.9 yrs attending grades 6-8 primary schools questionnaire asking symptoms within 2 h ingestion. total population sixth...
Vitamin D is believed to affect the progression and severity of atopic dermatitis (AD). Allergic sensitization may cause this effect vary. Individuals who fulfilled Hanifin Rajka criteria for AD underwent epidermal prick tests blood specific immunoglobulin E(IgE), serum total IgE, 25-hydroxy vitamin D, peripheral eosinophil count percentage. Disease was determined according Scoring Atopic Dermatitis (SCORAD) index. Patients were grouped allergic sensitization. Seventy-three children with...
The dietary protein proctocolitis, also known as allergic proctocolitis (AP), is characterized by the presence of mucoid, frothy, and bloody stools in an otherwise healthy infant. aim this study was to describe a group children with AP, diagnosed according criterion-standard method, food challenge provide clinicians more information on typical presentation, overview nutritional management strategies prognosis.We collected data infants AP our allergy gastroenterology outpatient clinics. Any...
Chronic urticaria (CU) is a skin disorder defined as daily or almost exhibition of pruritic and transient wheals that last for 6 weeks. CU divided into two subtypes: chronic spontaneous (CSU) inducible (CIndU).To evaluate the clinical features, possible causes, associated findings, laboratory results different subtypes in children according to new classification.In this study, we evaluated investigations, provocation tests with classification.Two hundred twenty-two (59.9% girls) were...
Objective: To compare a hydrogel dressing with conservative topical wound-care regimen (gauze povidone-iodine) for the treatment of pressure ulcers. Method: A prospective study comprising 27 (24 male and three female) spinal-cord injury patients total 49 Wounds were randomised into group (n=25) or control (n=24). The primary outcome measure was rate wound healing (cm2/days). Results: Healing rates in higher than group, although this not statistically significant. Some 84% wounds 54%...
Background Although food allergy is an important health problem in W estern countries, the prevalence varies among geographic regions. There limited data on of especially for adolescent age group, and from T urkey M editerranean region are even scarce. Methods The study a cross‐sectional survey including questionnaire followed by phone with families that have reported clinical evaluation children having history compatible after survey. sample number students has been calculated 9096 total...
Anaphylaxis is a potentially life-threatening condition. There are limited data about the etiology and clinical characteristics in developing countries. This study aimed to investigate of anaphylaxis patients attending our pediatric allergy clinic. We conducted prospective analysis who were admitted clinic for from 2010 2012. Ninety-six evaluated during period. The mean age was 7.4 ± 5.2 years. Venom, food, drugs most common causative agents responsible 31 (32.3%), 30 (31.3%), 26 (27.1%)...
Phytase was produced from Lactobacillus plantarum isolated a fermented food (Shalgam) and characterized in this study. Extracellular intracellular enzyme activities of L. were determined as 984.50 U/mL 494 U/g, respectively. Molecular weight extracellular phytase estimated to be 46 kDa, phytases 72 36 33 kDa by SDS-PAGE. Optimum temperature for activity 120°C, optimum pH 3.4. The 94% stable 10 min at 80°C. not significantly affected 1 mM CoCl2 1mM FeCl2. Intracellular 5 MnCl2.
The negative predictive value of the drug provocation test is important for both patient and physician. However, in children, this unresolved.The study included patients who had with a suspected was diagnosed as 'not allergic to drug'. Three months after allergy workup, were contacted asked reexposure tested drug. Patients have reported reactions during reevaluated skin tests provocation.During period, 217 provocations performed 203 patients. Of these, 163 (80.3%) 175 could be contacted....
<b><i>Background:</i></b> Several studies have demonstrated a relationship between asthma and obesity. However, the results been conflicting with regard to fractional exhaled nitric oxide (FeNO), used as marker of airway inflammation in asthmatic patients, We aimed evaluate association FeNO obesity obesity-related metabolic complications nonasthmatic children. <b><i>Methods:</i></b> The study population included children aged 6 17 years...
IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity thought to be increased in selective (sIgAD). However, it currently unclear if these coincide within families. We aimed evaluate frequency autoimmune children with sIgAD their first-degree relatives (FDRs).The study included 81 diagnosed 274 FDRs. presence was evaluated serum antithyroglobulin antithyroid peroxidase levels were measured both patients relatives.The mean age...
In this study, the phytase from Lactobacillus brevis strains isolated fermented food products was produced and characterized. Phytase production of strain determined by clear zones around colonies on sodium phytate containing medium, after 48 h incubation at 30 °C. The molecular weight estimated as 73 kDa 34 SDS-PAGE. optimum activity extracellular intracellular enzymes emerged 120 °C, pH 3.4 110 3.4, respectively. enzyme 91% stable for 5 min 90 significantly stimulated with HgCl2 (157%),...
Drug provocation tests (DPTs) are gold standard to diagnose drug allergy. Our goal was evaluate the results and safety of diagnostic methods including DPTs during childhood. Between January 2010 February 2013 were performed evaluated, prospectively, in children who attended our pediatric allergy clinic with a suspected hypersensitivity reaction. One hundred ninety-eight reactions 175 patients (88 boys 87 girls) evaluated. The median age subjects at time drug-induced reaction study 56...
Abstract Background Dedicator of cytokinesis 8 (DOCK8) deficiency is the main cause autosomal recessive hyper‐IgE syndrome (HIES). We previously reported selective loss group 3 innate lymphoid cell (ILC) number and function in a Dock8 ‐deficient mouse model. In this study, we sought to test whether DOCK8 required for maintenance ILC subsets humans. Methods Peripheral blood ILC1‐3 16 DOCK8‐deficient patients recruited at pretransplant stage, seven with dominant (AD) HIES due STAT3 mutations,...
Abstract Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where clinical phenotype, caused by single and/or multiple gene variants, can give rise to presentations. The advent of next‐generation sequencing (NGS) recently enabled rapid identification the molecular aetiology SCID, which is crucial for prognosis and treatment strategies. We sought identify various phenotypes SCIDs assessed both immunologic characteristics associated with variants. An amplicon‐based...