A5074001748- Clinical Laboratory Practices and Quality Control
- Meta-analysis and systematic reviews
- Statistical Methods in Clinical Trials
- Hemodynamic Monitoring and Therapy
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Sports Performance and Training
- Infant Nutrition and Health
- Neurological Disorders and Treatments
- Anesthesia and Sedative Agents
- Folate and B Vitamins Research
- Reliability and Agreement in Measurement
- Thyroid Disorders and Treatments
- Medical research and treatments
- Hydrology and Drought Analysis
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Muscle activation and electromyography studies
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal and reproductive studies
- Body Composition Measurement Techniques
- Neonatal Respiratory Health Research
- Sports injuries and prevention
- Neuroscience of respiration and sleep
Yeditepe University
2024
Giresun University
2022
Ergani Devlet Hastanesi
2022
Istanbul Health and Technology University
2021
Istanbul University
2021
Bursa Uludağ Üni̇versi̇tesi̇
2010-2020
Turkish Thoracic Society
2010
Erciyes University
2007
Abstract Background: Aspartate aminotransferase (AST), alanine (ALT) and γ-glutamyl transferase (GGT) measurements are important for the assessment of liver damage. The aim this study was to define reference intervals (RIs) these enzymes in adults, paying attention standardization methods used careful selection population. Methods: AST, ALT GGT were measured with commercial analytical systems standardized IFCC-recommended measurement systems. Three centers (two Italy one China) their own...
The reference intervals (RIs) given in laboratory reports have an important role aiding clinicians interpreting test results to values of healthy populations. In this report, we present a proposed protocol and standard operating procedures (SOPs) for common use conducting multicenter RI studies on national or international scale. protocols consensus their contents were refined through discussions recent C-RIDL meetings. describes detail (1) the scheme organization study, (2) target...
The IFCC Committee on Reference Intervals and Decision Limits coordinated a global multicenter study reference values (RVs) to explore rational harmonizable procedures for derivation of intervals (RIs) investigate the feasibility sharing RIs through evaluation sources variation RVs scale. For common protocol, rather lenient criteria individuals were adopted facilitate harmonized recruitment with planned use latent abnormal exclusion (LAVE) method. As July 2015, 12 countries had completed...
Reference intervals (RIs) are fundamental tools used by healthcare and laboratory professionals to interpret patient test results, ideally enabling differentiation of healthy unhealthy individuals. Under optimal conditions, a should perform its own RI study establish RIs specific for method local population. However, the process developing is often beyond capabilities an individual due complex, expensive time-consuming develop them. Therefore, can alternatively verify established external...
The intent of this study, based on a global multicenter study reference values (RVs) for serum analytes was to explore biological sources variation (SVs) the RVs among 12 countries around world. As described in first part paper, 50 major from 13,396 healthy individuals living were obtained. Analyzed 23 clinical chemistry and 8 measured by immunoturbidimetry. Multiple regression analysis performed each gender, country country, analyte analyte, setting four SVs (age, BMI, levels drinking...
Abstract A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and explore sources of variation values, including regionality. Blood samples were collected 28 laboratories from seven regions (≥400 samples/region, 3066 all). The sera collectively analyzed Uludag University Bursa using Abbott reagents analyzer. Reference materials used standardization test results. After secondary exclusion...
Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating profiles accurately. Our objective was to establish and define (1) the extent diurnal fluctuations in concentrations that potentially necessitate strict adherence time sample acquisition (2) time-dependent reference intervals.Nine markers were examined couplets males females.Using isotope dilution high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS)...
Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, harmonization standardization, future perspectives of indirect determination using routine laboratory data.
The complete blood count (CBC) with differential leukocyte (DLC) is one of the most common tests requested by physicians. results this test are affected storage temperature and time incubation. This study was designed to evaluate stability hematologic parameters in specimens stored for 48 h at three temperatures.K2-EDTA - collected from 22 healthy adults. CBC performed using a hematology analyser immediately; 0 point 4, 8, 12, 16, 20, 24, after 4 °C, 10 °C or 23 °C. Changes values were...
Abstract Varying concentrations of adiponectin are present in human breast milk. This study aimed to determine the relationship between milk concentration and hormonal inflammatory status breast-feeding women. Blood samples were collected from 157 women enrolled at 1–180 post-partum lactation days. The serum measured by radioimmunoassays. oestradiol, prolactin, thyroxine, triiodothyronine, cortisol insulin chemiluminescent immunometric method. leptin, resistin ghrelin methods. milk, but not...
The aim of this study was to define the reference intervals (RIs) in a Turkish population living Northeast Turkey (Erzurum) for 34 analytes using direct and indirect methods. In present study, regional RIs obtained were compared with other RI studies, primarily nationwide performed Turkey.For method, 435 blood samples collected from healthy group females (N = 218) males 217) aged between 18 65 years. sera analysed Ataturk University hospital laboratory Roche reagents analysers analytes. data...
Background: Choline is an important component of human breast milk and its content varies considerably among breastfeeding women lactation periods. Objective: The aim this study was to assess the relationship between choline contents inflammatory status in women. Methods: Breast compounds serum C-reactive protein (CRP) concentrations were determined at 1 3 (n = 53) or 22 180 54) days postpartum, expressing colostrum mature milk, respectively. Results: Median free choline, phosphocholine,...
Sepsis/endotoxemia causes platelet dysfunctions, abnormalities in coagulation and hemostatic mechanisms leading to organ dysfunctions mortality. Choline prevents injury improves survival during endotoxemia. The main objective of the present study was determine effects choline or cytidine-5'-diphosphocholine (CDP-choline) on endotoxin-induced activation development disseminated intravascular (DIC). Dogs were treated intravenously (i.v.) with saline, (20 mg/kg), CDP-choline (70 mg/kg) three...
Background: In a planned International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) worldwide study on reference intervals (RIs), common panel serum samples is to be measured by laboratories from different countries, test results are compared through conversion using linear regression analysis. This report presents validation that was conducted in collaboration with four laboratories.
Abstract Introduction A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration sources variation values (RVs). Materials and methods K2-EDTA whole blood samples (total 3363) were collected from 12 laboratories. Sera also measurements iron, UIBC, TIBC, ferritin use latent abnormal exclusion (LAVE) method. The analysed within 2 hours each laboratory using Cell Dyn Ruby (Abbott),...
Abstract Background Parenteral nutrition ( PN ) has been widely used in preterm infants. The lipid solutions for , however, are associated with oxidative stress and morbidity. aim of this study was to compare the effectiveness a new‐generation emulsion SMOFL ipid) olive‐oil based prevention ‐associated damage. Methods Preterm infants < 32 weeks gestational age were included prospective randomized study. All SMOF or (ClinOleic). Lipid peroxidation products evaluated all In addition, total...
Abstract Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677C‐>T 1298A‐>C are two most common mutations which can affect total (tHcy) status. This study was designed to determine the rate of mutations, their influence on serum folate, Hcy vitamin B12 status reference intervals in 402 healthy Turkish adults. The or 50.7% 54.7%, respectively. mutation‐specific tHcy were characterized by marked shifts upper limits. In homozygote...
Although a variety of different lipid emulsions with varying fatty acid contents have been developed, there are some concerns about the administration these because potential adverse effects, including oxidative stress-related morbidity. The aim present study was to evaluate and compare effects standard soybean oil-based olive i.v. (ILE) on stress, determined by total antioxidant capacity (TAC), investigate safety use two in terms biochemical indices.In this prospective study, premature...
To analyze consistency of reference limits and widths intervals (RIs) calculated by six procedures evaluate a protocol for merging intrainstitutional data.The differences between were compared with "optimal" bias goals. Also, the RIs compared. using Mayo-SAS quantile, EP Evaluator, four International Federation Clinical Chemistry Laboratory Medicine methods: parametric nonparametric (NP) without latent abnormal values exclusion (LAVE). Regression parameters from cotested samples evaluated...