A5033549936- Clinical Laboratory Practices and Quality Control
- Meta-analysis and systematic reviews
- Hemodynamic Monitoring and Therapy
- Quality and Safety in Healthcare
- Scientific Measurement and Uncertainty Evaluation
- Chronic Kidney Disease and Diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Healthcare cost, quality, practices
- Dialysis and Renal Disease Management
- Sepsis Diagnosis and Treatment
- Diabetes Management and Research
- Statistical Methods in Clinical Trials
- Ion channel regulation and function
- Gestational Diabetes Research and Management
- Cardiac electrophysiology and arrhythmias
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Muscle Physiology and Disorders
- COVID-19 diagnosis using AI
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Screening and Detection
- Renal Diseases and Glomerulopathies
- Cardiac Imaging and Diagnostics
- Risk and Safety Analysis
- Pesticide Residue Analysis and Safety
Streekziekenhuis Koningin Beatrix
2022-2025
Radboud University Nijmegen
2017-2025
Radboud University Medical Center
2020-2025
Amphia Ziekenhuis
2015-2024
Hamburg University of Technology
2024
Universität Hamburg
2024
Medicines Evaluation Board
2019-2022
Azienda Ospedaliera di Padova
2022
University of Padua
2022
Walter de Gruyter (Germany)
2022
Chronic kidney disease (CKD) is often detected late, leading to substantial health loss and high treatment costs. Screening the general population for albuminuria identifies individuals at risk of events cardiovascular (CVD) who may benefit from early start preventive interventions. Previous studies on cost-effectiveness screening were inconclusive, but based survey or cohort data rather than an implementation study, modelled as performed by practitioners home-based screening, included only...
External Quality Assurance (EQA) is vital to ensure acceptable analytical quality in medical laboratories. A key component of an EQA scheme performance specification (APS) for each measurand that a laboratory can use assess the extent deviation obtained results from target value. consensus conference held Milan 2014 has proposed three models set APS and these be applied setting EQA. goal arising this harmonisation between different schemes deliver consistent messages laboratories...
Abstract Objectives The novel coronavirus disease 19 (COVID-19), caused by SARS-CoV-2, spreads rapidly across the world. exponential increase in number of cases has resulted overcrowding emergency departments (ED). Detection SARS-CoV-2 is based on an RT-PCR nasopharyngeal swab material. However, testing time-consuming and many hospitals deal with a shortage materials. Therefore, we aimed to develop algorithm evaluate individual’s risk infection at ED. Methods In this multicenter...
Abstract ISO 15189 requires laboratories to estimate the uncertainty of their quantitative measurements and maintain them within relevant performance specifications. Furthermore, it refers TS 20914 for instructions on how what take into consideration when communicating measurement with requesting clinicians. These include responsibility verify that bias is not larger than medically significant. If estimated be acceptable, such first needs eliminated or (temporarily) corrected for. In latter...
Abstract Background The harmonization status of most tumor markers (TMs) is unknown. We report a feasibility study performed to determine whether external quality assessment (EQA) programs can be used obtain insights into the current α-fetoprotein (AFP), prostate specific antigen (PSA), carcinoembryonic (CEA), cancer (CA)125, CA15-3 and CA19-9. Methods EQA sample results provided by 6 providers (INSTAND [Germany], Korean Association External Quality Assessment Service [KEQAS, South Korea],...
Abstract The EN ISO 15189:2022 standard, titled “Medical laboratories – Requirements for quality and competence,” is a significant update to the regulations medical laboratories. revised standard was published on December 6, 2022, replacing both 15189:2012 22870:2016. Key objectives of revision include: 1. Alignment with ISO/IEC 17025:2017, 2. Removal unintended prescription, 3. Focus patient interest safety, 4. Minimization new requirements, 5. Improved clarity text. Dedicating harmonizing...
Abstract Clinicians trust medical laboratories to provide reliable results on which they rely for clinical decisions. Laboratories fulfil their responsibility accurate and consistent by utilizing an arsenal of approaches, ranging from validation verification experiments daily quality control procedures. All these procedures verify, different moments, that the a certain examination procedure have analytical performance characteristics (APC) meet specifications (APS) set particular intended...
Abstract Objectives According to ISO 15189:2022, analytical performance specifications (APS) should relate intended clinical use and impact on patient care. Therefore, we aimed develop a web application for laboratory professionals calculate APS based simulation of the measurement uncertainty (MU) outcome using chosen decision limits, agreement thresholds, data population interest. Methods We developed “APS Calculator” allowing users upload select concern, specify limits conduct simulations...
Plasma glucose levels provide the cornerstone of diabetes evaluation. Unfortunately, drop in vitro due to glycolysis. Guidelines suitable conditions which minimize glycolysis, such as immediate centrifugation or use ice/water slurry storage containers. For obvious practical reasons, most laboratories blood collection tubes containing glycolysis inhibitors. We describe effect a variety commonly used on stability glucose. Furthermore, we looked at validity assumption that glycolytic activity...
Optimum patient care in relation to laboratory medicine is achieved when results of tests are equivalent, irrespective the analytical platform used or country where located. Standardization and harmonization minimize differences success efforts achieve this can be monitored with international category 1 external quality assessment (EQA) programs.An EQA project commutable samples, targeted reference measurement procedures (RMPs) was organized by institutes Italy, Netherlands, Portugal, UK,...
Reference intervals are commonly used as a decision-making tool. In this review, we provide an overview on "big data" and reference intervals, describing the rationale, current practices including statistical methods, essential prerequisites concerning data quality, harmonization standardization, future perspectives of indirect determination using routine laboratory data.
Introduction Reliable serum creatinine measurements are of vital importance for the correct classification chronic kidney disease and early identification injury. The National Kidney Disease Education Programme working group other groups have defined clinically acceptable analytical limits methods. aim this study was to re-evaluate performance routine methods in light these so as assess their suitability clinical practice. Method In collaboration with Dutch External Quality Assurance scheme,...
Background External quality assessment (EQA) programs for general chemistry tests have evolved from between laboratory comparison to trueness verification surveys. In the Netherlands, implementation of such has reduced inter-laboratory variation electrolytes, substrates and enzymes. This allows national metrological traceable reference intervals, but these are still lacking. We initiated a endeavor named NUMBER (Nederlandse UniforMe Beslisgrenzen En Referentie-intervallen) set up sustainable...