A5076131007- Tissue Engineering and Regenerative Medicine
- Muscle Physiology and Disorders
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Chronic Kidney Disease and Diabetes
- Spine and Intervertebral Disc Pathology
- Silk-based biomaterials and applications
- Anesthesia and Pain Management
- Folate and B Vitamins Research
- Blood Pressure and Hypertension Studies
- Microfluidic and Capillary Electrophoresis Applications
- Chronic Disease Management Strategies
- Proteins in Food Systems
- Acute Kidney Injury Research
- Cellular Mechanics and Interactions
- Reliability and Agreement in Measurement
- Collagen: Extraction and Characterization
- Musculoskeletal pain and rehabilitation
- Lipid Membrane Structure and Behavior
- Muscle activation and electromyography studies
- Dialysis and Renal Disease Management
- Prenatal Substance Exposure Effects
- Clinical Laboratory Practices and Quality Control
- Pain Mechanisms and Treatments
- Pregnancy and preeclampsia studies
Amphia Ziekenhuis
2022-2024
Eindhoven University of Technology
2009-2015
Netherlands Organisation for Applied Scientific Research
2015
Skeletal muscle tissue engineering still does not result in the desired functional properties and texture as preferred for regenerative medicine meat production applications. Electrical stimulation has been appropriately used a tool to advance cell maturation vitro, thereby simulating nerve stimulation, part of niche vivo. We first investigated effects electrical protocols two-dimensional (2D) monolayers C2C12 translated these three-dimensional (3D) model system, based on collagen type...
Chronic kidney disease (CKD) is often detected late, leading to substantial health loss and high treatment costs. Screening the general population for albuminuria identifies individuals at risk of events cardiovascular (CVD) who may benefit from early start preventive interventions. Previous studies on cost-effectiveness screening were inconclusive, but based survey or cohort data rather than an implementation study, modelled as performed by practitioners home-based screening, included only...
Chronic low back pain due to intervertebral disc (IVD) degeneration is associated with increased levels of inflammatory mediators. Current medical treatment consists oral anti-inflammatory drugs alleviate pain. In this study, the efficacy and safety a novel thermoreversible poly-N-isopropylacrylamide MgFe-layered double hydroxide (pNIPAAM MgFe-LDH) hydrogel was evaluated for intradiscal controlled delivery selective cyclooxygenase (COX) 2 inhibitor drug celecoxib (CXB).Degradation, release...
Engineered muscle tissues can be used for several different purposes, which include the production of use as a disease model in vitro, e.g. to study pressure ulcers, regenerative medicine and meat alternative 1. The first reported 3D constructs have been made many years ago pioneers field are Vandenburgh colleagues 2,3. Advances tissue engineering not only result from vast gain knowledge biochemical factors, stem cells progenitor cells, but particular based on insights gained by researchers...
Measurement of plasma albumin is pivotal for clinical decision-making in patients with chronic kidney disease (CKD). Routinely used methods as bromocresol green (BCG) and purple (BCP) can suffer from aselectivity, but the impact aselectivity on accuracy results CKD-patients still unknown. Therefore, we evaluated performance BCG-, BCP- JCTLM-endorsed immunological various stages CKD.We commonly CKD G1 through G5, latter divided two groups based whether they received hemodialysis treatment. In...
Background Postoperative atrial fibrillation (POAF) is a common and serious complication after cardiac surgery. Existing clinical prediction models show limited discriminative ability. We hypothesize that incorporating biomarkers reflect key pathophysiological pathways of POAF can enhance preoperative risk stratification. Methods Adult surgery patients without history from the BIGPROMISE cohort - prospective, observational, two-centre perioperative biobank study were included to investigate...
Background: Postoperative atrial fibrillation (POAF) is a common and serious complication after cardiac surgery. Existing clinical prediction models show limited discriminative ability. We hypothesize that incorporating biomarkers reflect key pathophysiological pathways of POAF can enhance preoperative risk stratification. Methods: Adult surgery patients without history from the BIGPROMISE cohort—a prospective, observational, two-centre perioperative biobank study—were included to...
In intervertebral disc herniation with nucleus pulposus (NP) extrusion, the elicited inflammatory response is considered a key pain mechanism. However, cytokines are reported in extruded herniated tissue, even before monocyte infiltration, suggesting that tissue itself initiates inflammation. Since swells, we investigated whether this simple mechanobiological stimulus alone could provoke an cause pain. Furthermore, sustained-release cyclooxygenase-2 (COX2) inhibitor would be beneficial such...
Engineered muscle tissues can be used for several different purposes, which include the production of use as a disease model in vitro, e.g. to study pressure ulcers, regenerative medicine and meat alternative 1. The first reported 3D constructs have been made many years ago pioneers field are Vandenburgh colleagues 2,3. Advances tissue engineering not only result from vast gain knowledge biochemical factors, stem cells progenitor cells, but particular based on insights gained by researchers...
During normal pregnancy, the glomerular filtration rate (GFR) increases dramatically. Failure to obtain this physiological increase is an important risk factor for morbidity and mortality both mother child. The estimated GFR (eGFR) using serum creatinine levels unsuitable accurate measurement of renal function during pregnancy. Therefore, new biomarkers have been proposed. Elevated Cystatin C (CysC) Neutrophil Gelatinase-Associated Lipocalin (NGAL) are associated with failure preeclampsia...
Abstract Background Appropriate clinical decision-making relies on the interpretation of equivalent measurement results in context valid decision limits. Besides guideline-based limits, reference intervals (RIs) are commonly used to discriminate between abnormal and from “healthy” individuals. This study evaluated suitability RIs light analytical bias for laboratories Netherlands using one standardized, harmonized, unharmonized measurand (creatinine, hemoglobin, ferritin, respectively)....
Skeletal muscle is an appealing topic for tissue engineering because of its variety in applications. Evidently, engineered skeletal can be used the field regenerative medicine to repair muscular defects or dystrophies. Engineered constructs also as a model system drug-screening study physiology and etiology pressure sores. Besides these well known applications, new interest with high societal impact has arisen, being vitro cultured meat. Contemporary large-scale farming transportation...