A5019674860- Erythropoietin and Anemia Treatment
- Neuroblastoma Research and Treatments
- PARP inhibition in cancer therapy
- Glioma Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Electron Spin Resonance Studies
- Bipolar Disorder and Treatment
- Cancer Research and Treatments
- Reliability and Agreement in Measurement
- Erythrocyte Function and Pathophysiology
- Cancer therapeutics and mechanisms
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Historical Turkish Studies
- Meta-analysis and systematic reviews
- Cardiac Ischemia and Reperfusion
- Chemotherapy-induced organ toxicity mitigation
- Aldose Reductase and Taurine
- Hemodynamic Monitoring and Therapy
- Dementia and Cognitive Impairment Research
- Blood properties and coagulation
- Drug Transport and Resistance Mechanisms
- Neurological Disease Mechanisms and Treatments
- CAR-T cell therapy research
Dokuz Eylül University
2009-2021
University of Kyrenia
2019
Selçuk University
2019
Gazi University
2019
University Clinical Center of Kosovo
2019
National Research Council
2004
Neuroscience Institute
2004
Mario Negri Institute for Pharmacological Research
2004
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype-selective ligands allowing the separation of EPO's bioactivities at cellular level in animals. Carbamylated EPO (CEPO) or certain mutants did not bind to classical (EPOR) show any activity human cell signaling assays upon chronic dosing animal species. Nevertheless, CEPO various nonhematopoietic were cytoprotective vitro conferred...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects other tissues, including those of the nervous system. Enthusiasm recombinant human erythropoietin (rhEPO) as potential neuroprotective therapeutic must be tempered, however, by knowledge it enlarges circulating red cell mass increases platelet aggregability. Here we examined whether erythropoietic...
Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays critical hormonal role regulating erythrocyte production as well paracrine/autocrine in which locally produced EPO protects wide variety tissues from diverse injuries. Significantly, these functions are mediated by distinct receptors: hematopoiesis via receptor homodimer and tissue protection heterocomplex composed CD131, β common receptor. In present work, we have delimited tissue-protective domains within to short...
Erythropoietin (EPO) is a neuroprotective cytokine in models of ischemic and nervous system injury, where it reduces neuronal apoptosis inflammatory cytokines increases neurogenesis angiogenesis. EPO also improves cognition healthy volunteers schizophrenic patients. We studied the effect administration on gene-expression profile cortex rats after cerebral ischemia at early time points (2 6 h). treatment up-regulated genes already increased by ischemia. Hierarchical clustering analysis...
Objectives: In the field of laboratory medicine, minimizing errors and establishing standardization is only possible by predefined processes. The aim this study was to build an experimental decision algorithm model open improvement that would efficiently rapidly evaluate results biochemical tests with critical values evaluating multiple factors concurrently. Methods: built Weka software (Weka, Waikato, New Zealand) based on artificial neural network method. Data were received from Dokuz...
Erythropoietin (EPO) is a type I cytokine that utilizes different receptor isoforms either to maintain hematopoiesis or protect against injuries arise from widely diverse etiologies. EPO also facilitates healing by reducing inflammation and mobilizing endothelial progenitor cells participate in restorative neoangiogenesis, but it unclear which isoform responsible for whether this use varies according the of wound. In present studies carried out rat, we have utilized receptor-selective...
Gamma knife radiosurgery is an attractive noninvasive treatment of brain tumors and vascular malformations that minimizes collateral tissue damage. However, exposure normal to even low-dose radiation triggers a cascade acute chronic injury potentially significant morbidity mortality. Because many irradiated patients now survive for years, identifying methods prevent radiotherapy-induced damage major focus current research. Erythropoietin (EPO), cytokine produced locally by tissues in...
To evaluate the protective effects of acetyl L-carnitine (ALCAR) on cisplatin-induced nephrotoxicity in rats, and to gain insights into possible mechanisms ALCAR against nephrotoxicity.Twenty-eight Wistar rats were divided four groups. Group 1 was administered saline only, group 2 ALCAR, 3 cisplatin, 4 prior cisplatin. Rats sacrificed after 72 h cisplatin/saline infusion. Serum creatinine glomerular filtration rate values obtained, kidney samples examined by light electron microscopy....
This study was designed to determine the physiological effects of 3 preslaughter treatments (catching, crating, and transportation) on male female broiler chickens slaughtered at 35, 42, 49, 56 d age. At each age, 18 birds (3 per sex pen; replicate pens) were sampled after catching, transportation for 1 h core body (rectal) temperature (Rt), blood pH, gases (partial CO2 O2 pressures), ions (Na+, K+, Ca++, HCO3-), hemoglobin, plasma glucose, albumin, uric acid, creatine kinase (CK) activity,...
Alzheimer's disease (AD) is a severe multifactorial neurodegenerative proteopathy associated with advanced age. Discrepancies in the renal function of these patients compared to geriatric dementia have rarely been reported. In this study, we aimed disclose importance changes for pathogenesis AD.Patients AD (n=107) and without (n=124) (231 total) from Dokuz Eylul Cukurova University Hospitals were enrolled study. We measured serum Na, K, Cl, Ca, BUN, creatinine, total protein levels MDRD...
Abstract Introduction A nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration sources variation values (RVs). Materials and methods K2-EDTA whole blood samples (total 3363) were collected from 12 laboratories. Sera also measurements iron, UIBC, TIBC, ferritin use latent abnormal exclusion (LAVE) method. The analysed within 2 hours each laboratory using Cell Dyn Ruby (Abbott),...
<i>Introduction:</i> Cisplatin (CDDP) is an effective and widely used chemotherapeutic agent for pediatric tumors, ototoxicity one of the dose-limiting side effects. <i>Objective:</i> It was aim our study to investigate effect acetyl <i>L</i>-carnitine (ALCAR) on experimental CDDP by audiologic tests, histomorphologic, immunohistochemical ultrastructural examinations apoptotic pathways. <i>Materials Methods:</i> Wistar albino rats (n = 28) were...
Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as result replicative stress. It possible to take advantage stress, enhance it in targeted way fight cells. One such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), with key roles regulation initiation DNA replication. CDC7 overexpression present different cancers, small molecule inhibitors have well-documented anti-tumor effects. Here, we aimed test potential...
Background/aim: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 folic acid levels in disease other dementia patients, as potential screening test detect presymptomatic Turkish patients. Materials methods: evaluated patients well geriatric from Ankara, Dokuz Eylül, Çukurova university hospitals; 290 female male subjects...
Aim of the present study is to investigate effects medication with donepezil (acetylcholinesterase inhibitor) on liver and kidney function in Alzheimer's disease (AD) compare during short (one month) long term (six years) follow-ups. We evaluated female male patients from Cukurova [42 AD patients; (5 mg/day)] Dokuz Eylul [68 (10 University Hospital. The results compared geriatric population without dementia other words who are not donepezil. For evaluation all subjects underwent periodic...
Traumatic brain injury is an important social health problem due to the fact that young adults are more likely be affected, and advanced functional limitations observed in survivors. In this study, we aimed investigate protective effect of ferulic acid experimental trauma model.This study was performed March 2016 at Dokuz Eylül University Experimental Animal Laboratory. Subjects were randomly divided into 4 groups Control, Ethyl Alcohol, Trauma, Trauma/Ferulic Acid groups. For histological...
Neuroblastoma is an important pediatric tumor in which Myc-N amplification a well-known poor prognostic indicator. It has great diversity clinical behavior. The effect of pharmacologic agents used neuroblastoma treatment on expression still unclear.We analyzed changes by immunocytochemistry Myc-N-positive Kelly human cell line using retinoic acid and cytotoxic drugs (cisplatin, vincristine, cyclophosphamide, etoposide, doxorubicin) their combinations compared with control conditions. First,...
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Objective: It has been shown that many children who experience respiratory syncytial virus (RSV) infection in infancy develop recurrent wheezing episodes and asthma later. Viral role pathogenesis of is still a debate. We aimed to investigate the recurrence episodes, atopy serum cytokine levels encountered with RSV infection. Additionally, we compare these parameters non-RSV bronchiolitis. Material Methods: The study was conducted between January 2006 November 2008 Dokuz Eylul University...