A5003945184- Spine and Intervertebral Disc Pathology
- Erythropoietin and Anemia Treatment
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Botulinum Toxin and Related Neurological Disorders
- Cervical and Thoracic Myelopathy
- Myofascial pain diagnosis and treatment
- PARP inhibition in cancer therapy
- Shoulder Injury and Treatment
- Stroke Rehabilitation and Recovery
- Pregnancy-related medical research
- Respiratory Support and Mechanisms
- Neuroscience and Neuropharmacology Research
- Histone Deacetylase Inhibitors Research
- Child Abuse and Related Trauma
- Pituitary Gland Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Vascular Malformations Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Spinal Cord Injury Research
- Medical Imaging and Analysis
- Peripheral Nerve Disorders
Dokuz Eylül University
2012-2025
Dokuz Eylül Üniversitesi Hastanesi
2022
Institute of Molecular Medicine
2021
Dana-Farber Cancer Institute
2012
University of Palermo
2006
University of Messina
2006
Neuroscience Institute
2004
National Research Council
2004
Mario Negri Institute for Pharmacological Research
2004
William K. Warren Foundation
2003
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype-selective ligands allowing the separation of EPO's bioactivities at cellular level in animals. Carbamylated EPO (CEPO) or certain mutants did not bind to classical (EPOR) show any activity human cell signaling assays upon chronic dosing animal species. Nevertheless, CEPO various nonhematopoietic were cytoprotective vitro conferred...
The cytokine erythropoietin (EPO) possesses potent neuroprotective activity against a variety of potential brain injuries, including transient ischemia and reperfusion. It is currently unknown whether EPO will also ameliorate spinal cord injury. Immunocytochemistry performed using human sections showed abundant receptor immunoreactivity capillaries, especially in white matter, motor neurons within the ventral horn. We used global model rabbits to test exogenous can cross blood-spinal barrier...
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects other tissues, including those of the nervous system. Enthusiasm recombinant human erythropoietin (rhEPO) as potential neuroprotective therapeutic must be tempered, however, by knowledge it enlarges circulating red cell mass increases platelet aggregability. Here we examined whether erythropoietic...
Erythropoietin (EPO) functions as a tissue-protective cytokine in addition to its crucial hormonal role red cell production. In the brain, for example, EPO and receptor are locally produced, modulated by metabolic stressors, provide neuroprotective antiinflammatory functions. We have previously shown that recombinant human (rhEPO) administered within systemic circulation enters brain is neuroprotective. At present, it unknown whether rhEPO can also improve recovery after traumatic injury of...
Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays critical hormonal role regulating erythrocyte production as well paracrine/autocrine in which locally produced EPO protects wide variety tissues from diverse injuries. Significantly, these functions are mediated by distinct receptors: hematopoiesis via receptor homodimer and tissue protection heterocomplex composed CD131, β common receptor. In present work, we have delimited tissue-protective domains within to short...
Erythropoietin (EPO) is a neuroprotective cytokine in models of ischemic and nervous system injury, where it reduces neuronal apoptosis inflammatory cytokines increases neurogenesis angiogenesis. EPO also improves cognition healthy volunteers schizophrenic patients. We studied the effect administration on gene-expression profile cortex rats after cerebral ischemia at early time points (2 6 h). treatment up-regulated genes already increased by ischemia. Hierarchical clustering analysis...
Previous studies have shown that erythropoietin (EPO) has protective effects against ischemia/reperfusion (I/R) injury in several tissues. The aim of this study was to determine whether EPO could prevent intestinal tissue induced by I/R. Wistar rats were subjected ischemia (30 min) and reperfusion (60 min). A single dose (5000 U/kg) administered intraperitoneally at two different time points: either five minutes before the onset or reperfusion. At end period, jejunum removed for...
Object Spinal cord injury (SCI) is a devastating clinical syndrome for which no truly efficacious therapy has yet been identified. In preclinical studies, erythropoietin (EPO) and its nonerythropoietic derivatives asialoEPO carbamylated EPO have markedly improved functional outcome when administered after compressive SCI. However, an optimum treatment paradigm currently unknown. Because the uninjured spinal expresses high density of receptor (EPOR) in basal state, signaling through these...
Although chronic neck pain (CNP) is associated with impairments in balance, the effects of muscle stabilization training are unknown. In this study, we compared core (CS) and scapular (SS) via telerehabilitation on functionality, pain, depression young adults CNP. two-armed, randomized controlled assigned 41 participants CNP to either a CS ( n = 21) or SS 20) group. Both groups underwent for eight weeks. We evaluated postural stability (PS), limits (LOS), functionality (Neck Disability...
Erythropoietin (EPO) is a type I cytokine that utilizes different receptor isoforms either to maintain hematopoiesis or protect against injuries arise from widely diverse etiologies. EPO also facilitates healing by reducing inflammation and mobilizing endothelial progenitor cells participate in restorative neoangiogenesis, but it unclear which isoform responsible for whether this use varies according the of wound. In present studies carried out rat, we have utilized receptor-selective...
Gamma knife radiosurgery is an attractive noninvasive treatment of brain tumors and vascular malformations that minimizes collateral tissue damage. However, exposure normal to even low-dose radiation triggers a cascade acute chronic injury potentially significant morbidity mortality. Because many irradiated patients now survive for years, identifying methods prevent radiotherapy-induced damage major focus current research. Erythropoietin (EPO), cytokine produced locally by tissues in...
Although pituitary adenomas are usually benign lesions, their growth rate is highly variable and unpredictable. Apoptosis appears to be an important process in neoplastic lesions. The purpose of this study was investigate the expression apoptosis-related proteins including Bcl-2, bax p53 its correlation with hormone function, tumor size, local control, proliferative activity.The Bax hormonal function were determined formalin-fixed, paraffin-embedded tissue from 41 untreated using...
To determine practices of Turkish anaesthesiologists with regard to withholding and withdrawal life support from the critically ill.An anonymous questionnaire consisting 18 questions was mailed 439 members Society Anaesthesiology Reanimation.Three hundred 69 questionnaires were returned (84% response). Over 90% respondents indicated that they Muslim. We found 66% had initiated written or oral do-not-resuscitate orders, most frequently after discussion colleagues (82%).While a number...
Genomic instability is a hallmark of cancer cells, and this cellular phenomenon can emerge as result replicative stress. It possible to take advantage stress, enhance it in targeted way fight cells. One such strategies involves targeting the cell division cycle 7-related protein kinase (CDC7), with key roles regulation initiation DNA replication. CDC7 overexpression present different cancers, small molecule inhibitors have well-documented anti-tumor effects. Here, we aimed test potential...
In Brief Many drugs are tested intrathecally to investigate alternatives opioids. We aimed explore the analgesic and possible neurotoxic effects of chronic intrathecally-administered ketorolac tromethamine in rats. Catheters were placed via atlantoaxial interval 28 Wistar rats under anesthesia intraperitoneally-injected thiopental 30 mg/kg. Rats randomized into 4 groups administered repeated intrathecal doses therapy with 5-day intervals. The control group received 10 μL saline, other 50,...
AIM The aim of our study was to examine the effects use Transcutaneous Electrical Nerve Stimulation (TENS) in patients who had undergone spinal surgery on pain, functionality, depression and consumption analgesic agents. MATERIAL AND METHODS Fifty-Four were randomized placed into two groups, patient-controlled analgesia (PCA) plus TENS only PCA. To assess pain levels patients, Visual Analog Scale (VAS) used. In assessment their functional levels, Timed Up Go test (TUG) utilized depression,...
Lack of an intermediary piece that should have been placed between the pin and spring resulted in skull penetration due to a rapid waste spring's compensatory capacity. Checking integrity internal pieces be performed regularly. Designing as single might increase safety.
We aimed to evaluate reliability, radiological outcomes, and the impacts of anterior cervical hybrid construction on adjacent segments for multilevel degenerative disc disease (mCDDD) spondylotic spinal stenosis (SSS).A retrospective analysis was performed using data extracted from medical files 195 patients (105 males, 90 females; mean age: 47.7 years). From 2008 2018, these underwent symptomatic contiguous at least 2-level diseases spondylosis. Clinical including Neck Disability Index...
Background and objective: An inverse I:E ratio (inspiratory time > expiratory time) may have benefits in patients suffering trauma who requiring lung ventilation. However, this application be deleterious if there is concomitant head injury. We aimed to determine the physiological effects of pressure- volume-controlled modes (I:E = 2:1) ventilation lungs, while maintaining normocapnia, a rabbit model raised intracranial pressure (ICP). Methods: New Zealand White rabbits were anaesthetized...