A5034947980- Clinical Laboratory Practices and Quality Control
- Dialysis and Renal Disease Management
- Meta-analysis and systematic reviews
- Dermatoglyphics and Human Traits
- Cardiac Imaging and Diagnostics
- Renal function and acid-base balance
- Liver Disease Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Paraoxonase enzyme and polymorphisms
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Body Composition Measurement Techniques
- Nitric Oxide and Endothelin Effects
- Diabetes and associated disorders
- Cardiac Ischemia and Reperfusion
- Blood groups and transfusion
- Folate and B Vitamins Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- S100 Proteins and Annexins
- Statistical Methods in Clinical Trials
- Iron Metabolism and Disorders
- Chronic Kidney Disease and Diabetes
- Protein Interaction Studies and Fluorescence Analysis
- Inflammasome and immune disorders
Lokman Hekim Üniversitesi
2020-2024
United States Congress
2023
Sağlık Bilimleri Üniversitesi
2017-2023
Hacettepe University
2023
Trakya University
2023
Dokuz Eylül Üniversitesi Hastanesi
2023
Ministry of Health
2009-2021
Apple (United States)
2021
Eskişehir Osmangazi University
2021
Ordu University
2020
Calculating the sample size in scientific studies is one of critical issues as regards contribution study. The critically affects hypothesis and study design, there no straightforward way calculating effective for reaching an accurate conclusion. Use a statistically incorrect may lead to inadequate results both clinical laboratory well resulting time loss, cost, ethical problems. This review holds two main aims. first aim explain importance its relationship effect (ES) statistical...
Carnitine loss through dialysis membranes is shown to be related the lack of carnitine in long-term haemodialysis patients. It has been previously reported that patients might have benefited from supplementation.A total 21 chronic maintaining supplementation and controls (haemodialysis not receiving carnitine) were included study. L-carnitine was used intravenously three times a week after each session, at 20 mg/kg dose. C-reactive protein (CRP), lipid profile, transferrin, albumin levels...
Clinical chemists frequently encounter hemolyzed samples. Our study examines the effects of hemolysis on results 25 common biochemical tests. We collected 60 15-mL blood samples from inpatients and outpatients mechanically 10 mL in a two-step procedure. classified serum these as being nonhemolyzed, moderately hemolyzed, or severely then performed Statistical analysis showed that had greatest effect lactate dehydrogenase, acid phosphatase, potassium
In the present study, we assessed oxidative stress in patients with dilated cardiomyopathy of ischemic or idiopathic etiology. For this reason measured whole blood reduced glutathione, erythrocyte superoxide dismutase, susceptibility membranes and erythrocytes to peroxidation, SH content 12 (8 men 4 women, ages 31 66 years) cardiomyopathy, 11 3 32 65 21 healthy volunteers (12 9 25 67 years). There was no statistically significant difference between two patient groups for indicators studied...
The molecular mechanisms of migraine have not been fully clarified yet. Increased nitrosative and oxidative stress may be associated with attacks. Platelets play an important role in patients they can reflect the lability tissues to nitrosative/oxidative stress. In present study, we aimed determine levels markers platelets during headache-free attack periods. A total 56 subjects (22 without aura, 14 20 age- sex-matched healthy controls) were included study nitric oxide (NO) metabolites,...
Increased nitric oxide (NO) production may result in further brain damage via synthase uncoupling patients with acute ischaemic stroke by increasing free radical formation and oxidative stress. In this connection, we measured nitrite nitrate (NO metabolites), ischaemia-modified albumin (IMA) thiobarbituric acid-reactive substances (TBARS) stroke.We studied 41 (22 men 19 women, aged 65+/-13 years) 37 age- sex-matched controls 15 65+/-8 years). Blood samples were drawn within the first 24 h...
Alzheimer's disease (AD) is the most frequent cause of dementia and age important risk factor for AD. Aging associated with increased free radical production oxidative stress plays an role in pathogenesis 8-Hydroxy-2'-deoxyguanosine (8-OHdG) a biomarker indicating DNA damage. Paraoxonase 1 (PON1) high-density lipoprotein (HDL)-associated antioxidant enzyme prevents especially oxidation low-density lipoproteins. The aim this study to measure urinary 8-OHdG levels serum PON1 activity patients...
Abstract A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and explore sources of variation values, including regionality. Blood samples were collected 28 laboratories from seven regions (≥400 samples/region, 3066 all). The sera collectively analyzed Uludag University Bursa using Abbott reagents analyzer. Reference materials used standardization test results. After secondary exclusion...
Abstract Objectives This study aimed to objectively assess the potential severity of harm associated with erroneous results in 195 laboratory tests by surveying 514 specialist physicians and medical biochemistry experts. Methods The survey obtained participants’ (75 biochemists, 439 clinicians) opinions on for tests. comprehensive list errors their effects test were from literature, then matched scores, 1 (negligible effect) 5 (life-threatening injury/death), responses. Results Participants...
Background : Cardiomyopathy (CMP) is a common debilitating illness, associated with high mortality and poor quality of life. There extensive evidence from in vitro animal experiments that CMP state increased oxidative stress. Coenzyme Q10 (CoQ10) high-sensitivity C-reactive protein (hs-CRP) are important markers to evaluate the stress inflammatory status patients CMP. Methods A total 28 chronic stable heart failure (21 men 7 women, ages 18–76 years) were included study. Causes ischemic 17...
Abstract Scientific knowledge should be based on evidence. However, some scientific studies can carried out without sufficient And these may mislead subsequent studies. Ischemia-modified albumin (IMA) is a relatively newly proposed biomarker. It used not only for myocardial ischemia but also other pathological conditions in the body. IMA commonly measured by cobalt binding (ACB) assay. ACB simple colorimetric assay performed patients’ sera. claimed that because of or ischemia-reperfusion,...
Cardiovascular disease is a common cause of death for diabetic patients. High sialic acid levels (SA) and increased oxidative stress are important factors cardiovascular diseases. We aimed to research whether SA thiobarbituric reactive substances (TBARS) associated with the degree regulation investigate if TBARS can be controlled blood glucose levels. A total 179 subjects were included in study. Three groups, which comprised type 2 diabetes mellitus (DM) (DM group [DMG], n=149), impaired...
This study aimed to investigate the effects of lipemia on clinical chemistry and coagulation parameters in native ultralipemic (NULM) intravenous lipid emulsion (IVLE) spiked samples.
Abstract Objectives Clinical biochemistry laboratories (CBL) are the most frequently utilized laboratory group in healthcare, and their significance patient care is indisputable. This study investigated frequency pattern of test utilization rate CBL at two large hospitals’ outpatient inpatient clinics. Methods A total 43,732,428 tests, including clinical chemistry, immunoassay, coagulation, specific proteins, CBC, urinalysis, were conducted for 12,182,382 patients across hospitals different...
Reactive oxygen metabolites (ROMs) contribute to tissue injury in inflammatory bowel disease. The aim of this study is examine the role ROMs ulcerative colitis (UC). group consisted 27 patients with UC (14 active, 13 quiescent) and a control 10 various anal diseases. We measured content malondialdehyde (MDA), superoxide dismutase (SOD), myeloperoxidase (MPO) colorectal biopsies. MDA was by thiobarbituric acid assay. SOD MPO were using nitro blue tetrazolium odianisidine methods,...
Cardiovascular disease (CVD) is the major cause of mortality and morbidity hemodialysis (HD) peritoneal dialysis (CAPD) patients. We aimed to investigate cardiovascular risk factors their correlation with CVD in groups HD CAPD patients.Thirty patients, 30 patients healthy controls were included study. Apolipoprotein A-l (apo A-l), apolipoprotein B B), apolipoprotein(a) [Lp(a)] high-sensitivity CRP (hs-CRP) measured a Beckman Coulter nephelometer, homocysteine (Hcy) was determined an Agilent...
Abstract Background Although tests of global hemostasis prothrombin time ( PT ) and activated partial thromboplastin aPTT should not be used for prediction bleeding risk, these are often by many clinicians in daily practice particularly as a preoperative screening test. Robust biological variation BV data needed safe clinical applications tests. In this study, stringent protocol was followed to estimate the 's , fibrinogen levels. Methods Weekly blood samples were obtained from 28 healthy...