A5101603110- Liver Disease Diagnosis and Treatment
- Clinical Laboratory Practices and Quality Control
- Liver Diseases and Immunity
- Microscopic Colitis
- Bariatric Surgery and Outcomes
- Pancreatitis Pathology and Treatment
- Vitamin D Research Studies
- Renal function and acid-base balance
- Liver Disease and Transplantation
- Hemoglobinopathies and Related Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiovascular Issues in Pregnancy
- Tryptophan and brain disorders
- Diet and metabolism studies
- Lipid metabolism and disorders
- Inflammation biomarkers and pathways
- Ovarian function and disorders
- Hormonal Regulation and Hypertension
- Inflammasome and immune disorders
- Hidradenitis Suppurativa and Treatments
- Thyroid Disorders and Treatments
- Olfactory and Sensory Function Studies
- Pregnancy and preeclampsia studies
- Hematological disorders and diagnostics
- Vitamin C and Antioxidants Research
Memorial Ankara Hospital
2019-2025
Ankara Bilkent City Hospital
2025
Sağlık Bilimleri Üniversitesi
2018-2024
Ankara Numune Eğitim ve Araştırma Hastanesi
2011-2022
Ministry of Health
2018-2021
Gazi University
2015
Hacettepe University
2015
Uni Research (Norway)
2009
This study aimed to evaluate the efficacy of thrombopoietin (TPO), a growth factor and acute-phase reactant, as an early prognostic marker for predicting disease severity in patients with acute biliary pancreatitis. A total 72 pancreatitis admitted Ankara Numune Training Research Hospital, General Surgery Department, were included study. The was classified using 2012 Revised Atlanta Classification, blood samples collected from each patient within first six hours hospitalization measure TPO...
We investigated the relationship of ischemia-modified albumin (IMA) and high-sensitivity C-reactive protein (hsCRP) levels with direct (endocan) indirect (carotid intima-media thickness [cIMT] 24 hours urine excretion) endothelial dysfunction indicators in type 2 diabetes mellitus (T2DM). Patients T2DM (n = 88) 88 healthy individuals were included study. The median endocan (475.15 vs 216.37 pg/mL; P < .001, respectively) hsCRP (10.74 3.11 mg/L; mean IMA (0.64 ± 0.12 0.51 absorbance units;...
Ulcerative colitis (UC) is a chronic inflammatory disease characterized by recurrent inflammation and ulcerations of colonic mucosa an inappropriate delayed healing. Adenosine deaminase (ADA) cytoplasmic enzyme involved in the catabolism purine bases, capable catalyzing deamination adenosine, forming inosine result process. Although ADA has been shown to increase several conditions, there are no literature data indicating alteration UC.This study evaluated activity total serum 43 patients...
<br><b>Background:</b> Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which proposed as oxidative stress biomarker in patients with AA. <b>Aims:</b> The aim was to investigate presence IMA, small dense low-density lipoprotein (sd-LDL), visfatin AA patients. <b>Settings Design:</b> A hospital-based cross-sectional undertaken among controls. <b>Subjects...
Background. Despite advances in the understanding of pathophysiological basis autoimmune hepatitis (AIH), it is still difficult to delineate mechanisms involved progression from hepatic inflammation toward fibrosis. Our aim was study serum concentrations NO AIH different histological severity and possible effects immunosuppressive therapy on production. Materials methods. We studied metabolites (NOx) 47 consecutive patients with 28 age- sex-matched controls. Results. Serum NOx were higher...
There are no validated noninvasive markers of liver fibrosis in autoimmune hepatitis (AIH). An activated renin-angiotensin system (RAS) and its key element angiotensin-converting enzyme (ACE) have been implicated the pathogenesis hepatic fibrogenesis. We aimed to study assumed role RAS fibrogenic process whether serum concentration ACE can predict different stages AIH.Serum samples 73 consecutive patients who were diagnosed with AIH analysed for concentration. All underwent a biopsy.Serum...
Behçet's disease is a chronic inflammatory vasculitis presenting with immunological and endothelial changes. The aim of the present study to evaluate blood levels diagnostic markers which can be used in patients vascular involvement.Fifty (22 involvement) 30 healthy controls were included study. High-sensitivity C-reactive protein (hsCRP), erythrocyte sedimentation rate (ESR), tumor necrosis factor-α (TNF-α), apolipoprotein A1 (apoA1), B (apoB), high-density lipoprotein (HDL), low-density...
Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic disorders. We aimed investigate concentrations serum 25(OH)D3, lipid parameters, three known VDR polymorphisms (BsmI, FokI, TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF 105 controls. Seventy had no attack (group 1), 30 1-2 attacks 2), 23 3 or more 3) within last months. Serum...
Abstract Background Although tests of global hemostasis prothrombin time ( PT ) and activated partial thromboplastin aPTT should not be used for prediction bleeding risk, these are often by many clinicians in daily practice particularly as a preoperative screening test. Robust biological variation BV data needed safe clinical applications tests. In this study, stringent protocol was followed to estimate the 's , fibrinogen levels. Methods Weekly blood samples were obtained from 28 healthy...
To investigate serum cardiac troponin I levels before and after magnesium sulfate treatment in preeclamptic pregnant women.Fifty-five women were included the prospectively planned study. Study group patients (n = 25) hospitalized with a preeclampsia diagnosis while control 30) no medical or obstetric problem who had been attending antenatal clinic. Serum compared normal women. These also treatment. Mann-Whitney U-test was used for statistical analysis.Groups similar respect to age, gravity,...
Galectin-3 is a β-galactoside-binding lectin associated with cellular proliferation, inflammation and angiogenesis, which are the major characteristics of psoriatic skin.To investigate serum galectin-3 levels in psoriasis patients compared healthy controls to study its relationship disease characteristics.Seventy-eight diagnosed 78 age- sex-matched volunteers were included study. Serum galectin-3, IL-17, IL-6 TNF-α measured using Enzyme-linked immunosorbent assay (ELISA).Serum Galectin-3,...
Background This study is a retrospective evaluation of patients who were subject to mixing in our laboratory due prolonged APTT . The preliminary diagnoses, clinical manifestations, and results additional ordered tests reviewed. aims investigate whether repeating test with different assay prior performing mixed would be better alternative algorithmic approach order save both time costs. Methods We retrospectively evaluated 166 (65 females 101 males) isolated Additional identify the etiology...
Decreased Chitotriosidase Activity and Levels in Familial Mediterranean FeverDifferent studies have demonstrated changes chitotriosidase (ChT) activity concentrations multiple diseases.However, ChT not been concurrently evaluated patients with Fever (FMF).In this study, we analyzed the serum FMF.The study included a total of 80 FMF healthy controls.ChT enzyme were measured then compared between groups.ChT was by using fluorometric ELISA colorimetric methods.The median 10.00...
Measurement of parathyroid hormone (PTH) is essential in the investigation and management calcium metabolism disorders. To assess significance any assay result when clinical decision making biological variation (BV) measurand must be taken into consideration. The aim present study determining BV parameters for serum PTH.Blood samples were at weekly intervals from 20 healthy subjects ten weeks this prospective study. Serum "intact PTH" concentrations measured with electrochemiluminescence...