A5047015636- Viral Infections and Vectors
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Mosquito-borne diseases and control
- Cancer-related Molecular Pathways
- Reproductive Biology and Fertility
- Vector-Borne Animal Diseases
- Cancer-related gene regulation
- Retinal Diseases and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Epigenetics and DNA Methylation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Chronic Lymphocytic Leukemia Research
- Pregnancy and preeclampsia studies
- Tannin, Tannase and Anticancer Activities
- Folate and B Vitamins Research
- Adenosine and Purinergic Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Paraoxonase enzyme and polymorphisms
- Inflammasome and immune disorders
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Spondyloarthritis Studies and Treatments
Kırklareli University
2022-2025
Niğde Ömer Halisdemir Üniversitesi
2017-2022
Sivas Cumhuriyet Üniversitesi
2010-2021
Pamukkale University
2009-2019
Gaziantep University
2006
Erciyes University
2006
Abstract Background Epoxyeicosatrienoic acids (EETs) are closely associated with lipoprotein metabolism, and changes in lipid profiles potentially affect their levels functions. Given the alterations metabolism after cholecystectomy, this study aimed to investigate of four EET regioisomers (free esterified) patients cholelithiasis laparoscopic cholecystectomy (LC) explore correlations between these parameters. Methods This prospective involved 40 symptomatic who underwent LC. Plasma EETs...
Pulmonary nocardiosis is the major clinical manifestation of human and disseminated infection can be seen in immunocompromised patients. N. asteroides predominant pathogen associated with diseases. We report 2 cases pulmonary admitted infection, caused by rare species Nocardia: Nocardia transvalensis cyriacigeorgica.
Objective . Oxidative stress is considered to be the main factor in development of diabetic complications and tissue injury. our objective was investigate compare oxidant/antioxidant conditions detoxification mechanisms liver, lung, kidney, cardiac tissues, mitochondria rats with diabetes induced by streptozocin (STZ). Methods Rats were anesthetized administering 90 mg/kg ketamine hydrochloride 3 xylazine hydrochloride. Thoracic cavities incised open; tissues removed stored at<mml:math...
The most accepted view to explaining the pathogenesis of Crimean–Congo hemorrhagic fever (CCHF) is endothelial damage. This study was conducted in a University hospital investigate serum levels and prognostic significance vascular growth factor (VEGF) its receptor, soluble fms-like tyrosine kinase-1 receptor (sVEGFR-1) CCHF. Forty-eight consecutive hospitalized CCHF patients (grouped into severe illness non-severe illness) 40 healthy adults, as controls were enrolled. There statistically...
Abstract Crimean‐Congo hemorrhagic fever (CCHF) is a tick‐borne disease caused by the arbovirus virus (CCHFV). The CCHFV has single‐stranded RNA genome of negative sense. MicroRNAs (miRNAs) are key players in virus‐host interactions and viral pathogenesis. We investigated miRNA gene expression profiles patients with CCHF using microarray for first time world. Microarray analysis was performed mirBase Ver 21 (Agilent Technologies, Santa Clara, CA). All statistical analyses were across...
Vitamin D (VitD) is critical for the regulation of inflammatory processes, and VitD deficiency has been linked to several chronic disorders. We aimed investigate concentrations serum 25(OH)D3, lipid parameters, three known VDR polymorphisms (BsmI, FokI, TaqI) in patients with Familial Mediterranean fever (FMF), an autosomal recessive autoinflammatory disease. The study included 123 FMF 105 controls. Seventy had no attack (group 1), 30 1-2 attacks 2), 23 3 or more 3) within last months. Serum...
Background: Myeloid differentiation primary response 88 (MYD88) is a common adaptor protein that responsible for signaling from several receptors; mutations in this gene may play role the pathogenesis of lymphoma. Aim: We aimed to determine MYD88 L265P mutation frequency, level expression, and their associations with clinicopathological parameters mature B-cell non-Hodgkin lymphomas (NHLs). Methods: A total 68 patients were included study. The presence was analyzed by real-time polymerase...
Background: In this case-control study, we aimed to investigate the relationship between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lung cancer. Materials Methods: Total 200 individuals including 100 patients with cancer controls were analyzed. Genotyping of MTHFR was performed using PCR RFLP methods. Results: The majority men 90% smokers. We found that risk ratio for development LC 13-times higher in smokers compared non-smokers patient control groups our study...
Glycoprotein IIb/IIIa inhibitors are used in the acute coronary syndromes and percutaneous intervention as antiplatelet agents. However, these agents induce thrombocytopenia approximately 1% to 5% of patients, may lead bleeding complications. Abciximab is associated with higher incidence than eptifibatide tirofiban. We describe a case profound due on tirofiban treatment patient who underwent primary angioplasty.
Crimean-Congo hemorrhagic fever is an acute viral with a high mortality rate. Despite increasing knowledge about viruses, little known the pathogenesis of fever. In this study, we measured serum adenosine deaminase and xanthine oxidase levels in patients.Serum were sensitive colorimetric method described by Giusti Worthington 30 consecutive hospitalized patients (mean age 42.6 +/- 21.0). Laboratory tests confirmed their diagnoses Thirty-five subjects 42.9 19.1) served as control group.There...
In this study the association between K55R polymorphism, methylation level of EPHX2 promoter region, and PE was investigated in 520 individuals including 260 patients healthy pregnant women.K55R polymorphism were determined by real-time PCR using double-dye hydrolysis probes methylation-sensitive high-resolution melting analysis, respectively.The presence significantly higher cases (28.1%) than controls (17.3%), associated with increased risk (OR: 1.86; 95% CI: 1.09-2.63). Methylation levels...
Further elucidation of the molecular mechanisms underlying lung cancer (LC) is essential for development new effective therapeutic agents. Recently, involvement Wnt antagonists in oncogenesis has been demonstrated several cancers. The investigation their contribution to carcinogenesis still under investigation. We aimed investigate whether there a susceptibility or preventive effect antagonist gene polymorphisms on and/or prognosis LC. investigated 110 LC patients and 160 controls....
The purpose of this study was to investigate the serum levels malondialdehyde (MDA) which is a marker oxidative stress, monocyte chemoattractant protein-1 (MCP-1) has an important role in inflammation, and vitamin C antioxidant properties patients with wet age-related macular degeneration (wAMD).Thirty wAMD were included MDA, MCP-1, compared healthy participants (n = 30). Serum MDA measured using spectrophotometric method. MCP-1 determined by ELISA method.MCP-1 higher control group (p <...
The purpose of this study is to determine erythrocyte sedimentation rate (ESR), C - reactive protein (CRP), serum amyloid-A (SAA) and cholesterol levels in patients with Crimean-Congo Hemorrhagic Fever (CCHF) the relationship these parameters severity disease. By polymerase chain reaction enzyme-linked immunosorbent assay (ELISA) method 40 were diagnosed as CCHF 39 volunteer without any systemic disease whose blood taken their separated. SAA, CRP ESR measured ELISA, nephelometry Mix-Rate...
Objectives: To determine whether oxidative stress plays a role in the pathogenesis of hydatid cyst by examining levels total antioxidant status, oxidant index, and activities enzymes paraoxonase arylesterase patients with cyst. Methods: Thirty whom were positive for indirect hemagglutination Echinococcus granulosus IgG ELISA tests included patient group. Thirty-five healthy subjects that negative tests, did not have any parasites on stool inspection constituted control Total status...
Although several associations were found between Dicer rs3742330 single nucleotide polymorphism (SNP) and development prognosis of some epithelial cancers, relationship the SNP endometrial cancer (EC) has not yet been studied. We aimed to investigate prognostic role gene in EC patients.A total 80 patients control subjects included study. Real-time polymerase chain reaction allele discrimination technique was used for genotyping SNP.There no significant difference with regard genotype...