A5078378018- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- Hemoglobinopathies and Related Disorders
- Hemophilia Treatment and Research
- Blood disorders and treatments
- Rheumatoid Arthritis Research and Therapies
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Complement system in diseases
- Blood properties and coagulation
- Erythrocyte Function and Pathophysiology
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
Eskişehir Osmangazi University
2015-2024
Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Hastanesi
2013-2024
Eskişehir City Hospital
2021-2023
Medical Genetics Center
2021
Turkish Society of Hematology
2019
Kayseri Eğitim ve Araştırma Hastanesi
2012-2014
Kayser (Italy)
2012
Abstract Background Deletion of 13q14 [del(13q)] is the most common cytogenetic change (50%) in chronic lymphoblastic leukemia (CLL), and it a good prognostic factor if detected as sole aberration by FISH. However, observed clinical course CLL cases with del(13q) are quite heterogeneous responsible for this heterogeneity has not been established yet. Some investigators suggest type II deletion (include RB1 gene) associated more aggressive course. Also, suggested that burden have effect. In...
Primer immunologic defect in patients with idiopathic thrombocytopaenic purpura (ITP) result from autoreactive B-lymphocytes secreting antiplatelet antibodies. Dysfunctional cellular immunity has also great importance ITP pathogenesis. CD4+CD25+ regulatory T-cells have immunoregulatory features and it is able to inhibit CD4+CD25− CD8+ responses. an autoimmune disease; the T-cell levels of decrease during active state. According our findings, immunosuppressive treatments increase Treg cell...
Glucocorticosteroids, intravenous immunoglobulins, vincristine, danazol, and eltrombopag are used in refractory chronic idiopathic thrombocytopenic purpura (ITP). All those treatment modalities susceptible for thrombosis generation. There is an increased risk of the diseases' natural course. The case we present a resistant ITP patient who developed pulmonary intracardiac during multidrug treatment. Risk concomitant usage drugs rapid increase platelet count discussed.
Celiac disease is an autoimmune, familial that results in susceptibility to gluten cereal and products genetically susceptible individuals. The aim of the present study was investigate presence HLA-DQ2/DQ8 patients with celiac disease, their first-degree relatives, healthy community.HLA-DQ2/DQ8 analysis performed adult >18 years old (94 patients), relatives (89 people), group (102 individuals). Anemia, osteoporosis, diarrhea were interrogated patient also anti-tissue transglutaminase,...
To follow the progression of multiple myeloma (MM) disease, serum lactate dehydrogenase (LDH) levels are as useful markers beta-2 microglobulin and monoclonal immunoglobulin. With this study, we have presented a case patient with which was fulminant course, whose LDH were normal at onset diagnosis increasing 27 times more than disease progressed who showed development extramedullary plasmacytomas. The patient, an 80-year-old female, diagnosed stage IIIA IgA type melphalan-prednisolon (MP)...
Objective: Pro-inflammatory and pro-angiogenic cytokines play an important role in the pathogenesis of lymphoma, recent studies have shown that can be used as prognostic markers.Non-Hodgkin lymphoma (NHL) patients with high levels serum interleukin-6 (s-IL6) vascular endothelial growth factor (s-VEGF) poor prognosis shorter survival time.We aimed to determine pre-treatment s-IL6 s-VEGF their relation known markers, especially International Prognostic Index (IPI) scores, examine effects on...
Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 in highly immunosuppressed populations, such as patients hematological malignancies, is a point interest. We aimed analyze symptoms, complications, intensive care unit admissions, and mortality rates infected Turkey.In this multicenter study, we included 340 adult pediatric diagnosed from March November 2020....
Abstract Aim Cytopenia in the course of systemic lupus erythematosus ( SLE ) may be due to multiple factors. In this study, we aimed primarily evaluate detailed results bone marrow BM biopsies patients, secondly determine myelofibrosis MF frequency and thirdly compare morphologic findings as well clinical laboratory parameters between groups (with without cytopenic patients. Methods We retrospectively analyzed 224 patients’ files. Patients were divided into two according whether they had or...
Chronic myeloproliferative neoplasms (MPN) are clonal disorders of hematopoietic stem/progenitor cell characterized by thrombohemorrhagic complications and a tendency to transform into acute leukemia. The pathogenesis thrombosis in MPN is complex results from multifaceted interplay clinical disease-related factors. Rotational thromboelastometry (ROTEM) provides the complete rapid information about all stages coagulation process. Here, we assess ROTEM parameters as screening profile patients...
Systemic lupus erythematosus (SLE) may affect a number of systems, with the hematological system being one most common. Our aim is to determine existence cytopenia at diagnosis or during follow-up our SLE patients as well associated factors.A cohort that had been followed-up in Department Rheumotology from 1998 2015 was retrospectively assessed. Clinical and laboratory findings about were recorded.Out 221 composing cohort, already present 83.3% (n=184) time diagnosis. Anemia detected 56.1%...
To follow the progression of multiple myeloma (MM) disease, serum lactate dehydrogenase (LDH) levels are as useful markers beta-2 microglobulin and monoclonal immunoglobulin.With this study, we have presented a case patient with which was fulminant course, whose LDH were normal at onset diagnosis increasing 27 times more than disease progressed who showed development extramedullary plasmacytomas.The patient, an 80-yearold female, diagnosed stage IIIA IgA type melphalan-prednisolon (MP)...
Hydroxyurea, which is an inhibitor of ribonucleoside reductase and used as a systemic antitumor agent, frequently for the treatment myeloproliferative hematologic diseases. While most common side effect myelosuppression, gastrointestinal symptoms such nausea, vomiting, stomatitis, anorexia rash, skin ulcers, hyperpigmentation in nails, dermatologic toxicities like facial erythema may also be observed. At higher dosages, neurologic rarely seen (1,2). A 76-year-old female patient applied...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare subtype of AML characterized by the clonal proliferation precursors cells. It presents with an aggressive behavior. The clinical findings include cytopenia, particularly thrombocytopenia. Although it responds well to chemotherapy initially, relapse rule and prognosis poor. There limited data published in literature, making problematic define biological features, hence, appropriate therapeutic approach. are various treatment...