A5007578242- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Hepatitis B Virus Studies
- Peptidase Inhibition and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood disorders and treatments
- CAR-T cell therapy research
- Blood groups and transfusion
- Hepatitis C virus research
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Kruppel-like factors research
- Nutrition and Health in Aging
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer Treatment and Pharmacology
- Blood Pressure and Hypertension Studies
- Complement system in diseases
- HER2/EGFR in Cancer Research
Akdeniz University
2015-2024
Akdeniz University Hospital
2023-2024
Antalya IVF
2022
Kahramanmaraş Sütçü İmam University
2020
The University of Texas MD Anderson Cancer Center
2016-2019
Sivas State Hospital
2018
Hacettepe University
2007
Muscle mass, defined as the psoas muscle index (PMI), is an important parameter of sarcopenia and it has been shown to be a prognostic factor non-hematological cancers. This study aimed investigate impact using PMI measurement in patients with diffuse large B-cell lymphoma treated R-CHOP. We retrospectively investigated pretreatment on survival response treatment. One hundred twenty DLBCL were included study, whom 65 had baseline according cutoffs. Sarcopenic displayed worse treatment...
Endothelial dysfunction, which is characterized by an imbalance between relaxing and contracting factors, procoagulant anticoagulant substances, pro-inflammatory mediators, may play a particularly significant role in the pathogenesis of atherosclerosis. Numerous experimental clinical reports suggest that high von Willebrand factor (vWF) level reflects endothelial damage or dysfunction. Hypertensive retinopathy (HR) condition spectrum retinal vascular signs people with elevated blood...
Pretransplant inflammatory and nutritional status has not been widely explored in terms of its impact on autologous hematopoietic stem cell transplantation (auto-HSCT) outcomes lymphoma patients. We aimed to evaluate the body mass index (BMI), prognostic (PNI), C-reactive protein albumin ratio (CAR) auto-HSCT outcomes.We retrospectively analyzed 87 consecutive patients who underwent their first at Adult Hematopoietic Stem Cell Transplantation Unit Akdeniz University Hospital.The CAR had no...
To minimize adverse events of peripheral blood stem cell (PBSC) collection in healthy donors, it is reasonable to limit the total dose granulocyte colony-stimulating factor (G-CSF) and/or number apheresis days without decreasing PBSCs yield. Therefore, we have started collect G-CSF induced on day 4 instead 5. So, retrospectively aimed investigate results this 4-day administration.
In this study, we aimed to obtain real-life data on the use of antimyeloma agents, which significantly increase overall survival (OS) in multiple myeloma (MM) patients, primary plasma cell leukemia (pPCL) patients with a poor prognosis.
BACKGROUND Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo‐HSCT has substantial risks, particularly in elderly, and its role older MDS patients yet to be defined. METHODS We analyzed 88 aged ≥ 60 years allo‐HSCT after reduced intensity conditioning regimens over last decade. The study cohort had high risk features; 47 of (53.4%) were > 65 age, 24 (27%) cytogenetic abnormalities...
Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 in highly immunosuppressed populations, such as patients hematological malignancies, is a point interest. We aimed analyze symptoms, complications, intensive care unit admissions, and mortality rates infected Turkey.In this multicenter study, we included 340 adult pediatric diagnosed from March November 2020....
Introduction Idiopathic intracranial hypertension (IIH) (pseudotumor cerebri) is a rare side effect of all-trans retinoic acid (ATRA). IIH cases have been observed after the concomitant use ATRA with azole group antimicrobials such as fluconazole and voriconazole. Here, we discuss about diagnosis treatment process emerging in young acute promyelocytic leukemia (APL) case impact, which can be increased by posaconazole. Case A 19-year-old male patient was diagnosed APL. Headache blurred vision...
The prognostic value of the geriatric nutritional risk index (GNRI) is not clear in patients with diffuse large B-cell lymphoma (DLBCL). This study was designed to analyze GNRI DLBCL and investigate its DLBCL. archive records between 2008 2020 at Akdeniz University Hospital were retrospectively analyzed. A total 206 recruited classified into two GNRI-based groups based on nutrition status. cut off determined by ROC analysis. In univariate Cox regression analysis for overall survival (OS),...
Background: Immune thrombocytopenia (ITP) is an autoimmune disorder.It characterized by due to thrombocyte destruction mediated autoantibodies; however, cytotoxic and defective regulatory T-lymphocytes play important role in its pathogenesis.While childhood ITP usually acute, self-limiting generally seasonal nature, adults chronic; relation with seasons has not been studied.Aims: We investigated whether months and/or have triggering roles ITP.Study Design: Descriptive study.Methods: A...
Currently 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computerized tomography (PET/CT) is being successfully used for staging and follow-up of Hodgkin's lymphoma (HL) non-Hodgkin's (NHL). Various studies have demonstrated that PET/CT effectively detects bone marrow involvement (BMI) concordant with biopsy (BMB) findings, thus it deemed as a complementary method. This study was aimed to evaluate18F-FDG-PET/CT efficiency detection BMI in HL NHL.The included 172 cases...
Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin with marked biologic heterogeneity. MYC and BCL2 rearrangements have been reported in a proportion of DLBCLs, where they may be associated adverse clinical outcome. The aim this study was to determine the frequency translocations DLBCL assess prognostic impact patients.In present study, we evaluated expression patterns CD 10, BCL6, MUM 1 by immunohistochemistry 121 cases tissue microarray (TMA): 62 germinal center B-cells...
The reactivation rate of chronic hepatitis B virus infection in cancer patients and chemotherapy regimens thought to be associated with were investigated.In all, 3,890 included this study. Mortality rates, regimens, types, number positive serology rates obtained.Only 354 had results (HBsAg+). Twenty-four (6.7%) HBsAg reactivation. In reactivation, the usage 5-fluorouracil (5-FU), cisplatin, cyclophosphamide, doxorubicin, steroid, rituximab, vincristine found significantly higher than...
Chronic myelogenous leukemia (CML) is a clonal hematological disorder, which characterized by the presence of classical or variant Philadelphia translocations. During progression to blastic phase disease secondary chromosomal abnormalities may emerge. Such are nonrandom, more frequent ones being trisomy 8 and 19, supernumerary i(17q), extra chromosomes. Furthermore, minor percentage patients acquire different including translocations between other We report here patient with Ph+ CML...
The aim of this study was to evaluate the efficacy cyclophosphamide-based (CB) and platinum-based (PB) chemotherapy regimens for hematopoietic stem cell mobilization in patients with Multiple Myeloma (MM), Hodgkin's lymphoma (HL), non-Hodgkin's (NHL) less well-known IEV (iphosphamide, epirubicin, etoposide) regimen terms harvesting competence, factors affecting com-petence, toxicity.A retrospective evaluation made 203 (94 MM, 37 HL, 72 NHL) peripheral blood different between 2000 2010 at...
The aim of this study was to assess the plasma levels von Willebrand factor antigen and ristocetin cofactor activity, which are well-known markers endothelial function, in atrial fibrillation (AF) with or without mitral stenosis (MS). Forty-two patients (16 MS AF [MS(+)AF(+)], 13 nonvalvular [MS(-)AF(+)], sinus rhythm [MS(+)AF(-)]) were included. Von activities all participants assessed. Overall, AF(+) higher than AF(-) (P = .003 P .002, respectively). 3 groups found be different .012 .01,...
The importance of parameters that predict and prevent relapse has increased in thrombotic thrombocytopenic purpura (TTP), where response overall survival rates exceed 90% with current approaches. In this respect, we examined the clinical presentations, laboratory findings, treatments, treatment responses, states relapsed/refractory disease immune-mediated TTP (iTTP) patients western Mediterranean region. 35 adult who were diagnosed iTTP last 10 years included study. median follow-up period...