A5072281402- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Dermatology and Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune and Inflammatory Disorders
- Drug-Induced Adverse Reactions
- Acne and Rosacea Treatments and Effects
- Skin and Cellular Biology Research
- Ocular Diseases and Behçet’s Syndrome
- Oral Health Pathology and Treatment
- Hidradenitis Suppurativa and Treatments
- Pediatric health and respiratory diseases
- Skin Protection and Aging
- Dermatological and COVID-19 studies
- Galectins and Cancer Biology
- melanin and skin pigmentation
- Hair Growth and Disorders
- CAR-T cell therapy research
- Single-cell and spatial transcriptomics
- Nail Diseases and Treatments
- RNA regulation and disease
- Retinal and Optic Conditions
- Restless Legs Syndrome Research
- Immune cells in cancer
- Telomeres, Telomerase, and Senescence
Ankara University
2015-2025
IBM (United States)
2023
Ankara Numune Eğitim ve Araştırma Hastanesi
2016-2019
Sağlık Bilimleri Üniversitesi
2018-2019
Epidermolysis bullosa acquisita (EBA) is a rare subepidermal bullous disease. Long-term remission in this disease difficult using current treatments, unlike that patients with other autoimmune diseases.We retrospectively evaluated the effectiveness and side effects of rituximab-intravenous immunoglobulin (IVIg) combination treatment five EBA resistant to conventional treatment.Rituximab (375 mg/m2) was administered for four consecutive weeks patients, their continued IVIg at dose 2...
Rosacea may result in emotional distress and anxiety. However, data on the presence of generalized anxiety disorder rosacea patients are scarce.The aim study was to detect frequency level depression with rosacea.A total 194 consecutive age- sex-matched controls were enrolled. Severity assessed according criteria National Society Ethics Committee. Both evaluated by Generalized Anxiety Disorder 7-item scale, severity measured Disorder-Adult.Individuals who diagnosed an and/or depressive more...
Backround: Despite extensive usage of systemic isotretinoin in patients with acne for many years, laboratory monitoring protocols adverse effects depend on the centers and there is no standardized practice frequency type testing. We aimed to decrease unnecessary standardize our general clinical department as well provide patient comfort cost saving. Materials methods: The medical charts 704 treated were reviewed retrospectively. National Cancer Institute common terminology criteria events...
<br><b>Background:</b> Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which proposed as oxidative stress biomarker in patients with AA. <b>Aims:</b> The aim was to investigate presence IMA, small dense low-density lipoprotein (sd-LDL), visfatin AA patients. <b>Settings Design:</b> A hospital-based cross-sectional undertaken among controls. <b>Subjects...
Background: Previous reports indicate that juvenile Behçet’s disease (BD) may have a different course than adult BD. However, as direct comparison with Behçet patients has only been made in limited number of studies, the issue is still controversial. Objectives: The primary aim our study was to compare clinical manifestations large cohort and registered single centre. secondary data newly diagnosed between 1998 2020 those 1976 1997. Methods: Data were collected retrospectively from medical...
Background: Acne Vulgaris is a chronic inflammatory disease that requires long-term treatment. Adherence to treatment problem in diseases and may affect outcomes.Objective: We aim investigate adherence satisfaction of patients with acne identify independent factors them.Methods: Five hundred were included this cross-sectional study. Demographic clinical characteristics the recorded. Severity was assessed using Investigator Global Assessment (IGA) scale, five-point Likert scale used assess...
Palmoplantar pustulosis is a chronic and relapsing disease of the palms soles, which characterized by scattered clusters pinhead-sized, sterile pustules.The aim present study was to determine demographic features, co-morbidities, relation palmoplantar with psoriasis.A total 48 patients (M/F: 15/33) were enrolled in study. A detailed history regarding age onset, duration, number recurrences, personal family psoriasis, accompanying arthritis, sternoclavicular tenderness, dental fillings,...
Olmsted syndrome is a rare congenital keratinization disorder characterized by mutilating palmoplantar keratoderma, often accompanied flexion deformity, periorificial keratotic plaques and hair abnormalities. The majority of cases are attributed to mutations in TRPV3. We report patient with sporadic case recurrent c.1717G&gt;T p.Gly573Cys variant TRPV3, who demonstrated clinical improvement when treated the epidermal growth factor inhibitor erlotinib.
The synergistic effect of two mutations the innate immune system may facilitate hyperactivation and dysregulation inflammasome in skin macrophages. This case connects diseases, hidradenitis suppurativa porokeratosis, by central role autoinflammation.
Büllöz pemfigoid (BP) farklı Avrupa ülkelerinde milyonda 7-43 arasında değişen insidansı ile en sık izlenen edinilmiş otoimmün büllöz hastalıktır [1][2][3][4] .Yakın tarihli çalışmalarda hastalık insidansındaki artış vurgulanmıştır 3 .Hemidesmozomal proteinlerden ikisi olan BP180 (tip XVII kollajen) ve BP230'a karşı gelişen otoantikorların yol açtığı dermoepidermal ayrışma patogenezinde önemli rol oynar.Tipik olarak hastalarda hem eritematöz enflamatuvar deri de normal görünümlü üzerinde...
Galectin-3 is a β-galactoside-binding lectin associated with cellular proliferation, inflammation and angiogenesis, which are the major characteristics of psoriatic skin.To investigate serum galectin-3 levels in psoriasis patients compared healthy controls to study its relationship disease characteristics.Seventy-eight diagnosed 78 age- sex-matched volunteers were included study. Serum galectin-3, IL-17, IL-6 TNF-α measured using Enzyme-linked immunosorbent assay (ELISA).Serum Galectin-3,...
Management of chronic urticaria (CU) is often difficult with oral antihistamines (OAs) despite long-term use.The aim this study was to determine the extent medication compliance (MC) and assess factors affecting MC patients CU toward OA therapy.A 43-item questionnaire administered 201 adult patients. A score (CS) 6 points chosen as a cutoff point. CS 0-6 corresponds poor 6-9, good compliance. Subsequently, associations compliant poorly groups were made by univariate multivariate analyses.The...
Alopecia areata (AA) is an autoimmune disease where dysregulations along with genetic susceptibility are hypothesized to play a role in pathogenesis.The aim of this study evaluate HLA-A, HLA-B, HLA-C, HLA-DQB1, and HLA-DRB1 profile its relationship clinical features AA patients.Ninety-eight patients 100 healthy controls were included the study. frequencies analyzed using polymerase chain reaction-sequence specific primers (PCR-SSP).HLA-B*39 HLA-HLA-DRB1*15 allele increased (p = .022 p .023,...
Lichen planus pigmentosus-inversus (LPP-inversus) which is an uncommon variant of lichen planus, characterized by well bordered hyperpigmented macules and patches involving intertriginous areas. Since it was first defined, very few cases have been reported worldwide. Herein we report eight new patients with characteristic features LPP-inversus. The lesions our were mostly located on axilla the inguinal region. Two also had that clinically consistent classic planus. Three unilateral...
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Background: Erythema nodosum (EN) is the most common clinical variant of panniculitis.It may occur in association with a wide variety causative stimuli.The aim our study to describe possible etiologic factors associated EN and compare them series previously reported literature.Materials Method: This retrospective chart review 287 patients who have presented clinic tender erythematous nodular lesions finally diagnosed as eythema between January 2010 December 2015.Results: Our included 239...
Background and Design: Humanized monoclonal antibody omalizumab was developed for the treatment of moderate-to-severe asthma.However, recently, reports on successful use in resistant chronic urticaria are increasing literature.Materials Methods: We retrospectively evaluated response, adverse effects duration remission 13 spontaneous patients treated with between May 2010 January 2014.Results: In ten thirteen omalizumab, urticarial lesions were suppressed no side observed.Conclusion: Our...
Objective:The aim of this study is to assess the impact omalizumab on coagulation biomarkers and immunoglobulin E (IgE) levels in chronic idiopathic urticaria/chronic spontaneous urticaria (CIU/CSU) bullous pemphigoid (BP) patients.Methods: Medical records 31 CIU/CSU 16 BP patients were reviewed according inclusion exclusion criteria.Laboratory parameters for status IgE at baseline first 12-week period therapy retrieved analysed light clinical response treatment.Results: At baseline,...
Abstract Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome and telomere biology disorder, usullay consisting of triad oral leucoplakia, dystrophic nails, reticular skin pigmentation. The diagnosis in the majority cases can be made following all clinical findings this are established. Here we report 7 years-old boy who had leukoplakia nail abnormality without involvement, associated with diagnosed X-linked DC due to dyskerin (DKC1) mutation. Our emphasizes fact that...
Pyoderma Gangrenosum (PG) is a chronic disease characterized by recalcitrant skin ulcers. We aimed to evaluate the demographic, clinical characteristics, treatments and factors affecting treatment responses of patients with PG. performed multicenter study 12 tertiary care centers. analyzed data who were followed up diagnosis PG between years 2012‒2022 retrospectively. included total 239 whom 143 female 96 male, an average age 54.2 ± 17.4 years. The most common was systemic steroids (n = 181,...