Aylın Okçu Heper

ORCID: 0000-0002-7807-0717
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Research Areas
  • Cutaneous lymphoproliferative disorders research
  • Cancer and Skin Lesions
  • Autoimmune Bullous Skin Diseases
  • Nail Diseases and Treatments
  • Cutaneous Melanoma Detection and Management
  • Nonmelanoma Skin Cancer Studies
  • Ocular Oncology and Treatments
  • Vascular Tumors and Angiosarcomas
  • Sarcoma Diagnosis and Treatment
  • Glioma Diagnosis and Treatment
  • Genetic and rare skin diseases.
  • Urticaria and Related Conditions
  • Fungal Infections and Studies
  • Tumors and Oncological Cases
  • Autoimmune and Inflammatory Disorders
  • Lymphoma Diagnosis and Treatment
  • Corneal Surgery and Treatments
  • Ocular Diseases and Behçet’s Syndrome
  • Drug-Induced Adverse Reactions
  • Eosinophilic Disorders and Syndromes
  • Vascular Malformations and Hemangiomas
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Genital Health and Disease
  • Teratomas and Epidermoid Cysts
  • Skin and Cellular Biology Research

Ankara University
2016-2025

Institute of Dermatology
2023

Sağlık Bilimleri Üniversitesi
2022

Psychiatric Association of Turkey
2020

AT Sciences (United States)
2018

Ludwig-Maximilians-Universität München
2017

St. Jude Children's Research Hospital
2015

Institut Curie
2015

Erzurum Regional Training and Research Hospital
2015

Fatih University
2012

The similarity between clinical pictures of pigmented actinic keratosis (PAK) and lentigo maligna (LM) is well known.To investigate the frequency dermatoscopic findings suggestive LM/lentigo melanoma (LMM) in other facial skin lesions (FPSL) to assess distinguishing dermoscopic criteria PAK LM.Eighty-nine FPSL were evaluated with conventional dermatoscopy. showing one or more features considered as specific patterns for diagnosis LM/LMM, mainly slate-grey black dots globules, areas,...

10.1111/j.1365-2133.2010.10025.x article EN British Journal of Dermatology 2010-09-07

Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell (BCC) and squamous (SCC) transition zone between them. However, dermoscopic features BSC are not well described in the published work, except one study. The aim present study was to better identify clarify findings largest group patients work describe its according histopathologically BCC-dominant, SCC-dominant intermediate categories. Dermoscopic 36 proven their dermatopathological correlates were...

10.1111/1346-8138.13563 article EN The Journal of Dermatology 2016-08-29

Transformed mycosis fungoides (T-MF) is a rare variant of MF with an aggressive course. In this study, we aimed to describe characteristics MF/Sezary syndrome (SS) patients transformation.Patients diagnosed T-MF among MF/SS between 2000 and 2014 in tertiary single center were evaluated retrospectively. Demographic data, clinical laboratory immunophenotype features, response treatment, survival, histopathologic features analyzed.Among 254 patients, 25 identified (10.2%) included the study....

10.4274/tjh.2016.0502 article TR Turkish Journal of Hematology 2017-05-22

Carvacrol containing products such as Origanum onites have been used phytotherapeutic agents in the treatment of serious skin injury. It has suggested that carvacrol is active component these herbs because its anti-microbial property. With activity and an ingredient herbs, a promising molecule for In present study, we evaluated efficacy on healing progress after excisional Here, Wistar-Albino rats were divided into two groups treated with vehicle. was administrated topically at concentration...

10.5530/pj.2014.3.2 article EN Pharmacognosy Journal 2014-04-11

Sehr geehrte Herausgeber, Die klassische Mycosis fungoides (MF) ist durch Flecken, Plaques und Tumorläsionen in sonnengeschützten Bereichen gekennzeichnet. MF kann viele entzündliche Erkrankungen imitieren sich mit unterschiedlichen morphologischen Befunden präsentieren.1 seborrhoischen Keratosen (SK) ähnliche eine seltene klinisch-pathologische Variante der MF, von bisher nur zwei Fällen berichtet wurde. Eine SK-ähnliche Betracht gezogen werden, wenn epidermale atypische Lymphozyten...

10.1111/ddg.15590_g article DE JDDG Journal der Deutschen Dermatologischen Gesellschaft 2025-01-01

Purpose: To investigate anterior segment swept-source optical coherence tomography (AS SS-OCT) findings in ocular surface tumors and simulating conditions. Methods: AS SS-OCT imaging histopathologic data pertaining to 92 eyes of 86 cases collected between September 2018 April 2023 were evaluated. Results: The 3 most common lesions conjunctival nevus (18 eyes), squamous neoplasia (OSSN, 16 pterygium/pinguecula (13 eyes). Excisional/incisional biopsy was performed 58 (67.4%) cases. On SS-OCT,...

10.1097/ico.0000000000003856 article EN Cornea 2025-03-28

Introduction: Eccrine poroma (EP) is a benign adnexal tumor. Establishing definitive diagnosis based on clinical and dermoscopic findings can be challenging. Objectives: The aim of this study to perform comprehensive analysis the features pigmented, hypopigmented, non-pigmented variants EP compare these in patients with dark light Fitzpatrick skin phototypes. Methods: A total 26 cases histopathologically confirmed were included. Each case was categorized as or melanin content within lesion....

10.5826/dpc.1502a5071 article EN cc-by-nc Dermatology Practical & Conceptual 2025-04-30

Endometriosis is an estrogen-dependent disease characterized by the presence of endometrial tissue outside uterine cavity, causing pelvic pain and infertility in 10% reproductive-aged women. It unclear why ectopic endometrium remains viable only a subset ERK1/2 plays key intracellular roles activating cellular survival differentiation processes.We sought to determine activity patients with endometriosis its possible regulating cell survival.ERK1/2 phosphorylation expression throughout...

10.1210/jc.2007-2051 article EN The Journal of Clinical Endocrinology & Metabolism 2008-06-18

Summary Background Nasal polyposis (NP) is a chronic inflammatory disorder of the upper respiratory tract, which often coexist with asthma. However, pathogenesis especially in patients NP still matter debate. Objective To better understand immunopathologic mechanism involved this relationship, we investigated cell profiles bronchial and nasal tissues alone concomitant Methods Seventeen (six male, 11 female, age range: 19–63, mean age: 38.29±13.27 years) were selected for study. Subjects...

10.1111/j.1365-2222.2005.02194.x article EN Clinical & Experimental Allergy 2005-03-01

Abstract Background/Objective There are a limited number of studies regarding the dermoscopic features and dermatopathological correlations Kaposi sarcoma. The primary objective this study was to evaluate sarcoma, secondary investigate their correlates. Methods Dermoscopic clinical analysis 222 lesions from 38 patients with histologically confirmed darcoma were assessed by two investigators. A total 83 biopsies available different stages. Additionally, 3 mm punch biopsy performed where newly...

10.1111/ajd.13150 article EN Australasian Journal of Dermatology 2019-09-08

Behçet disease (BD) presents with lymphocytic and neutrophilic vasculitis of unknown aetiology. HLA‐B*51, the endoplasmic reticulum aminopeptidase 1 (ERAP1), interleukin 23 receptor (IL23R)/IL12R are genetic risk factors. IL‐23 regulates IL‐17A, which controls recruitment activation neutrophils. To determine pathological changes in BD skin lesions related to complex predisposition. We characterized expression IL‐17A IL‐23A various cell types by immunohistological double staining sections...

10.1111/bjd.20643 article EN cc-by-nc British Journal of Dermatology 2021-07-13

Purpose: To evaluate the presentation patterns and results of management retinoblastoma at a tertiary care center in Ankara, Turkey, with special emphasis on globe conservation rate unilateral bilateral intraocular retinoblastoma. Methods: Patients were grouped according to International Classification Retinoblastoma. For retinoblastoma, group E some D eyes underwent primary enucleation. Secondary enucleation was performed after failure chemoreduction, focal treatments, external beam...

10.3928/01913913-20130730-02 article EN Journal of Pediatric Ophthalmology & Strabismus 2013-09-01

Summary. To determine whether combination treatment of HBeAg(−) chronic hepatitis B is beneficial we studied 78 patients with HBeAg(−), HBV DNA‐positive who were randomized to lamivudine, 100 mg, qd, for 12 months or lamivudine–interferon (9 MU, t.i.w.) in combination. In the arm, 2 lamivudine preceded 10 treatment. Biochemical, virologic and histologic responses assessed at end treatment, after six a median 27 drug‐free follow‐up (short‐ long‐term follow‐up, respectively). Virologic...

10.1111/j.1365-2893.2005.00566.x article EN Journal of Viral Hepatitis 2005-03-10

To evaluate the efficiency of amniotic membrane in prevention adhesion formation after strabismus surgery.A prospective, controlled study was conducted on 20 eyes 10 pigmented rabbits. After disinsertion superior rectus muscle, under muscle insertion area to induce formation, a partial-thickness 4 x mm sclerectomy performed both eyes. In right eyes, piece appropriate size human sutured site. As control group, left were operated with similar procedure but without transplantation. 2 months,...

10.1177/112067210901900601 article EN European Journal of Ophthalmology 2009-11-01

Journal Article Cardiomyopathy with alopecia and palmoplantar keratoderma (CAPK) is caused by a JUP mutation Get access H. Erken, Erken Departments of Cardiology Search for other works this author on: Oxford Academic Google Scholar K.O. Yariz, Yariz Dr John T. Macdonald Foundation, Department Human Genetics P. Hussman Institute Genomics, 1501 NW 10th Avenue, Miami, FL 33136, U.S.A. D. Duman, Duman Division Pediatric Genetics, Ankara University School Medicine, Dikimevi, 06100, Turkey C.T....

10.1111/j.1365-2133.2011.10455.x article EN British Journal of Dermatology 2011-06-11

Liver biopsy to assess fibrosis is invasive and prone sampling error. While algorithms of serum markers predict stage have been described for chronic hepatitis C, these cannot be applied equally well B.We therefore determined 9 markers, liver biochemical tests ultrasound parameters in 109 consecutive adult patients with B D. All had compensated disease. Using the METAVIR score, advanced disease was defined as ≥F2, active inflammation grade ≥A2. A gold standard created considering...

10.4318/tjg.2011.0217 article EN The Turkish Journal of Gastroenterology 2011-06-01
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