A5088796684- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Amoebic Infections and Treatments
- Antibiotic Use and Resistance
- Clinical Nutrition and Gastroenterology
- Respiratory viral infections research
- Antibiotics Pharmacokinetics and Efficacy
- Pneumocystis jirovecii pneumonia detection and treatment
- Nosocomial Infections in ICU
- Pediatric Hepatobiliary Diseases and Treatments
- Neutropenia and Cancer Infections
- Oral microbiology and periodontitis research
- Bacterial biofilms and quorum sensing
- Surgical Sutures and Adhesives
- Heparin-Induced Thrombocytopenia and Thrombosis
- Respiratory Support and Mechanisms
- Blood disorders and treatments
- Pleural and Pulmonary Diseases
- Otolaryngology and Infectious Diseases
- Respiratory and Cough-Related Research
- biodegradable polymer synthesis and properties
Munzur University
2023
Istanbul University
2013-2022
İstanbul Eğitim ve Araştırma Hastanesi
2014
Turkish Society of Cardiology
2012
Abstract Determination of the etiology bacterial meningitis and estimating cost disease are important in guiding vaccination policies. To determine incidence Turkey, cerebrospinal fluid (CSF) samples were obtained prospectively from children (1 month–17 years age) with a clinical diagnosis acute meningitis. Multiplex PCR was used to detect DNA evidence Streptococcus pneumoniae, Haemophilus influenzae type b (Hib), Neisseria meningitidis. In total, 408 CSF collected, determined 243 cases; N....
Successful vaccination policies for protection from bacterial meningitis are dependent on determination of the etiology meningitis. Cerebrospinal fluid (CSF) samples were obtained prospectively children 1 month to ≤18 years age hospitalized with suspected meningitis, in order determine Turkey. DNA evidence Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumoniae), and Hemophilus influenzae type b (Hib) was detected using multiplex polymerase chain reaction (PCR). In...
The etiology of bacterial meningitis in Turkey changed after the implementation conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) Turkish National Immunization Program (NIP). Administration Hib vaccine PCV-7 (7-valent pneumococcal conjugate vaccine) was implemented NIP 2006 2009, respectively. In 2011, replaced with PCV-13. Meningococcal have not yet been included NIP. This prospective study comprised 27 hospitals located seven regions represented...
This is an observational epidemiological study to describe causes of bacterial meningitis among persons between 1 month and 18 y age who are hospitalized with suspected in 7 Turkish regions. covering 32% the entire population Turkey. We present here results from 2013 2014. A clinical case was defined according followings: any sign including fever, vomiting, headache, meningeal irritation children above one year fever without documented source, impaired consciousness, prostration seizures...
Objective To evaluate the serotype distribution and antibiotic resistance in pneumococcal infections adults to provide a perspective regarding coverage of both current future vaccines.Patients methods This passive surveillance study was conducted with Streptococcus pneumoniae strains isolated from specimens patients pneumonia (materials bronchoalveolar lavage), bacteraemia, meningitis, pleuritis peritonitis between 2015 2018. Serogrouping serotyping were performed by latex particle...
Abstract Background With the availability of new broad‐spectrum antibiotics, initial therapy with a single agent has become an alternative to classic combinations, especially β‐lactam antibiotics plus aminoglycosides, in management febrile neutropenic cancer patients. Procedure Since January 1994, monotherapy been used for empiric treatment at our center. The aim this prospective randomized study is compare efficacy cefepime (CFP), fourth‐generation cephalosporin, and ceftazidime (CFZ) as...
To determine the prevalence of antimicrobial resistance among Streptococcus pneumoniae and Haemophilus influenzae isolated in Turkey as part Survey Of Antibiotic Resistance, a surveillance programme Africa Middle East region examining susceptibility key bacterial pathogens involved community-acquired respiratory tract infections (CARTIs). Susceptibility was evaluated against range agents using disc diffusion Etest methods. Six centres five cities collected 301 S. 379 H. isolates between...
Background: To characterize the methicillin-resistant Staphylococcus aureus (MRSA) clones present in Istanbul, 102 MRSA isolates collected during a 5-year period at Istanbul Medical Faculty Hospital were characterized using microarray analysis and phenotypic resistance profiles.Methods: Resistance to methicillin was detected with cefoxitin disk diffusion assay confirmed MRSA-agar detection kit.Antimicrobial susceptibility testing performed by interpreted according 2012 guidelines of...
ABSTRACT Streptococcus pneumoniae is the most common etiological cause of complicated pneumonia, including empyema. In this study, we investigated serotypes S. that empyema in children. One hundred fifty-six children who were diagnosed with pneumonia 13 hospitals seven geographic regions Turkey between 2010 and 2012 included study. Pleural fluid samples collected by thoracentesis tested for 14 serotypes/serogroups using a Bio-Plex multiplex antigen detection assay. The specified 33 156...
Successful vaccination policies for protection from invasive pneumococcal diseases (IPD) dependent on determination of the exact serotype distribution in each country. We aimed to identify serotypes strains causing IPD children Turkey and emphasize change before after with 7-valent conjugate vaccine (PCV-7) was included PCV-13 newly changed Turkish National Immunization Program. Streptococcus pneumoniae were isolated at 22 different hospitals Turkey, which provide healthcare services...
Objectives: The aims of this study were to investigate the incidence bacteremia, bacteriology and antibiotic susceptibility against causative bacteria associated with dental implant installation.Study Design: 30 generally healthy patients enrolled in study.Blood samples collected at baseline minutes after installation 24 hours surgery.Blood cultured a BACTEC system.The isolated identified using conventional methods.Antimicrobial sensitivity tests performed by disc diffusion.Results: No...
Procalcitonin (PCT) and C-reactive protein (CRP) are important biological markers used in the diagnosis of severe infections. The aim this study was to evaluate consistency blood culture with PCT CRP differentiating contamination non-bacteremia from true bacteremia. In samples were obtained 809 febrile patients analyzed using BACTEC 9120 system. All positive cultures performed Gram staining. microorganisms identified conventional methods automated systems. Antibiotic susceptibility tests...
To assess the antibiotic resistance, transposon profiles, serotype distribution and vaccine coverage rates in 110 erythromycin-resistant S. pneumoniae clinical isolates.Erythromycin, clindamycin, tetracycline, chloramphenicol kanamycin susceptibilities were assessed using E-test/disc diffusion method. Inducible macrolide resistance was tested erythromycin-clindamycin double disc test. Serogrouping serotyping performed latex particle agglutination Quellung reaction, respectively. Drug genes...
Objectives: To determine the serotype distribution of pneumococcus causing invasive pneumococcal disease (meningitidis, bacteremia and empyema) in children Turkey, to observe potential changes this time guide effective vaccine strategies.Methods: We surveyed S. pneumoniae with conventional bacteriological techniques real-time polymerase chain reaction (RT-PCR) samples cerebrospinal fluid (CSF), blood pleural fluid. strains were isolated from 33 different hospitals which are giving health...
To investigate changes in antibiotic susceptibility of Streptococcus pneumoniae and Haemophilus influenzae from the Survey Antibiotic Resistance (SOAR) community-acquired respiratory tract infections (CA-RTIs) between 2002 2009 Turkey.Previously published SOAR data were used for this analysis. MICs determined using Etest(®) gradient strips or disc diffusion. Susceptibility against a range antimicrobial agents was assessed CLSI breakpoints.A total 900 S. isolates analysed: 2002-03 (n = 75),...
ABSTRACT Before use of the pneumococcal conjugate vaccine PCV7 became widespread in Turkey, 202 invasive pneumococcus isolates were analyzed. The most common serotypes 19F and 6B. In children ≤2 years age, potential coverage rate was 69.5%. frequent non-PCV7 19A, 3, 1, 6A, 8.
Background: The treatment of methicillin-resistant staphylococcal infections has been a growing problem both in and out hospitals for the past 30 years. Therefore, there is need other antibiotics as an alternative to glycopeptides infections. This study investigated vitro susceptibility 49 Staphylococcus aureus (MRSA) 59 coagulase negative staphylococci (MRCNS) clinical isolates daptomiycin, telithromycin, tigecyclin, quinupristin/dalfopristin, linezolid. Methodology: identification strains...
Abstract Background Medicinal leech, Hirudo medicinalis , has been used in plastic and reconstructive surgery, to relieve venous congestion improve the microrevascularization of flaps. In many countries, wild leeches are still provided from local markets utilised with antibiotic prophylaxies. this research, results identification bacteria transport fluid is reported, oral intestinal floras antibiograms identified microorganisms investigated. Also, avoid possible infections, ability...