A5069661827- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Hemoglobin structure and function
- Neonatal Health and Biochemistry
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Social Media in Health Education
- Acute Myeloid Leukemia Research
- Prenatal Screening and Diagnostics
- Folate and B Vitamins Research
- Congenital Diaphragmatic Hernia Studies
- Genomics and Rare Diseases
- Reproductive Health and Contraception
- Hemophilia Treatment and Research
- Health Literacy and Information Accessibility
- Patient-Provider Communication in Healthcare
- Vascular Tumors and Angiosarcomas
- Parvovirus B19 Infection Studies
- Lymphoma Diagnosis and Treatment
Wayne State University
2015-2025
Michigan United
2025
Agios Pharmaceuticals (United States)
2021-2024
Children's Hospital of Michigan
2015-2022
Palmetto Hematology Oncology
2022
Central Michigan University
2020-2022
Detroit Medical Center
2015-2020
Duke University
2019
Vanderbilt University Medical Center
2019
University Medical Center
2019
We aimed to identify predictors of outcomes and survival in patients living 4 major metropolitan areas who had sickle cell disease (SCD) COVID-19 inform best approaches prevention care. Data were collected at baseline during the clinical course SCD diagnosed with four epicenters. Patients followed up posthospital discharge for 3 months. Of sixty-six COVID-19, fifty (75%) required hospitalization, seven died (10.6%). preexisting kidney (chronic disease) more likely be hospitalized. The most...
Background: Acute vaso-occlusive pain episodes in sickle cell disease (SCD) are associated with increased rates of hospitalization and early mortality. Despite the observation that women have higher acute than men, sex-specific risk factors for not been identified. We tested hypothesis is temporally onset menstruation SCD. Methods: Initially, using a cross-sectional study design, we administered questionnaires, including validated measures SCD frequency severity within last 30 days, as well...
Women with sickle cell disease (SCD) are living longer as a result of advances in the care their underlying disease. With population growing women SCD, reproductive health issues this have become an emphasized area medical care. We sought to describe current patterns contraception use, menstruation, and quality-of-life (QOL) measures SCD.Using cross-sectional study design, we administered paper surveys at two academic centers aged 10 55 years SCD capture contraceptive characteristics...
The measurement of band 3 (AE1, SLC4A1, CD233) content red cells by eosin-5- maleimide (EMA) staining is swiftly replacing conventional osmotic fragility test as a tool for laboratory confirmation hereditary spherocytosis across the globe. Our group has systematically evaluated EMA method to screen variety anemias in last 10 years, and compared these results those obtained with gradient ektacytometry (osmoscans) which we have used over three decades. overall experience allowed us...
Piezo1, encoded by the gene PIEZO1, is an erythrocytic cellular membrane mechanoactivated cation channel. Mutations have been implicated in erythrocyte volume disorders (EVDs)—especially hereditary xerocytosis (HX)/dehydrated stomatocytosis (DHS). We identified three patients, all with novel PIEZO1 mutations, but only one displaying HX/DHS phenotype. Retrospective review of cases. Osmotic gradient red cell deformability (Osmoscan) was assessed via Technicon Ektacytometer. Red band 3 content...
The pivotal Endari trial in sickle cell disease showed a reduction pain crises events. This reanalysis of the l-glutamine phase 3 using annual rates crises, consistent with other SCD studies, supported statistically significant outcomes original analysis. observed 45% difference VOC rate is comparable to what was reported therapeutics used reduce incidence pain. results presented this communication are informative for clinicians evaluating treatment effects across available therapeutic...
RUNX1 associated familial platelet disorder (FPD) is a rare autosomal dominant hematologic characterized by thrombocytopenia and/or altered function. There an increased propensity to develop myeloid malignancy (MM) - acute leukemia, myeloproliferative neoplasms or myelodysplastic syndrome often in association with secondary somatic variants other genes. To date, 23 FPD-MM pediatric cases have been reported worldwide. Here, we present two new kindreds novel pathogenic which children are...
Summary Blood cell adhesion to P‐selectin and vascular molecule‐1 (VCAM‐1) contributes the pathophysiology of vaso‐occlusion crisis (VOC) events in individuals with sickle disease (SCD). We evaluated use standardized flow biomarkers a six‐month, 35‐subjects longitudinal study (ELIPSIS). Flow whole blood on (FA‐WB‐Psel) VCAM1 (FA‐WB‐VCAM), isolated white cells (FA‐WBC‐Psel) VCAM‐1 (FA‐WBC‐VCAM) were elevated VOC days compared non‐VOC days, but only FA‐WB‐Psel reached statistical significance...
After a thirty-year lag, we serendipitously reestablished contact with patient glucose phosphate isomerase deficiency and hydrops fetalis first reported in 1987. We now provide clinical update results of mutation analysis this patient, from Southern India. The an adult female 36 years age has moderate anemia but requires no transfusions except some intercurrent illnesses. Exome sequencing studies showed homozygous c.1018C>T (Pro340Ser) exon 12 the gene later confirmed by direct sequencing....
Summary Sickle cell disease (SCD) is characterized by frequent and unpredictable vaso‐occlusive crises (VOCs). erythrocytes (SSRBCs) contribute to VOCs participating in a series of adhesive events with blood cells the vascular endothelium. Adhesion assays have been used evaluate relationship between SSRBC adhesion SCD severity. We developed standardized, clinical flow assay whole molecule (FA‐WB‐VCAM). The objective this study was assess variability predictive value FA‐WB‐VCAM six‐month...
The human phosphoglycerate kinase-1 enzyme is the first of two energy generating steps in glycolysis. Since its discovery 1968, many pathologically mutated forms PGK1 have been described. expressed all tissues. clinical manifestations deficiency are some combination anemia, central nervous system and/or musculoskeletal manifestations. We describe a case an African-American child, which to our knowledge, has never described date. PGK1-Detroit (c.1105A > C (p.Thr369Pro)) include hematologic and
Navigating a new terrain: how Twitter is changing hematologistsOn 26 April 1958, the hematology universe converged on Atlantic City, New Jersey, as 300 hematologists met, just they have every year since, to discuss groundbreaking discoveries of before and revolutionary shifts in medical care that would inevitably follow.This inaugural meeting American Society Hematology (ASH) was set decade innovation.It had been 5 years since aspirin found protect against myocardial infarction, 1...
Evidence suggests neuropathic pain (NP) develops over time in sickle cell disease (SCD), contributing to a complex, difficult-to-treat phenotype, with management based on scant evidence. One characteristic of NP found is hyperalgesia caused by nervous system sensitization, but risk factors for this have not been identified within the SCD population, as exact mechanisms leading its development are well defined. The SPICE (Sickle Pain: Intervention Capsaicin Exposure) trial was pilot safety...