A5100349874- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- Nutritional Studies and Diet
- Genomics and Phylogenetic Studies
- Hemoglobinopathies and Related Disorders
- Antibiotic Resistance in Bacteria
- Iron Metabolism and Disorders
- Inflammation biomarkers and pathways
- Health and Wellbeing Research
- Glaucoma and retinal disorders
- Signaling Pathways in Disease
- Biosimilars and Bioanalytical Methods
- Berberine and alkaloids research
- Selenium in Biological Systems
- Bioactive Compounds and Antitumor Agents
- Cervical and Thoracic Myelopathy
- Safe Handling of Antineoplastic Drugs
- Muscle Physiology and Disorders
- Spinal Cord Injury Research
- Piperaceae Chemical and Biological Studies
- Phytochemistry and Biological Activities
- Patient Safety and Medication Errors
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
Jinan University
2025
Luye Pharma (China)
2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Sun Yat-sen University
2001-2023
Second Military Medical University
2023
Shanghai Changzheng Hospital
2023
Beijing University of Chemical Technology
2023
Peking University
2023
Peking University Third Hospital
2023
Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, is frequently associated with multidrug resistance and global epidemic outbreaks, contributing significantly to morbidity mortality in hospitalized patients. However, P. aeruginosa belonging the sequence type (ST) 16 was rarely reported. Here, this report presents complete genome of YK01, ST16 isolate from patient keratitis. The reference YK01 expected provide valuable data for investigating its genomic population, enhancing...
Abstract Background: Health education has been considered as the effectiveness method to increase self-care skills of diabetes patients. However, limited studies investigate association health via Wechat platform on increased basic and glycemic control rate in patients with type 2 diabetes. Methods: A total number 120 were randomized into intervention (health by plus usual care) group (usual care). Biochemical parameters including fasting plasma glucose (FPG), 2-hour (2hPG), glycosylated...
A systematic analysis of clinical trials supporting rare cancer drug approvals may identify concepts and terms that can inform the effective design prospective for cancers. In this article, using annual incidence ≤6 100,000 individuals to define "rare cancer," we identified cancers, U.S. Food Drug Administration (FDA) indications between December 1987 May 2011. We characterized each selected trial study design, sample size, primary efficacy endpoints, statistical comparisons. also profiled...
The long-term associations between dietary copper (Cu) and selenium (Se) intakes type 2 diabetes mellitus (T2DM) risk are unclear. We aimed to examine the prospective Cu Se T2DM in Chinese adults. A total of 14,711 adults from China Health Nutrition Survey (1997-2015) were included. Nutrient assessed by 3 consecutive 24 h recalls food-weighing methods. was identified a validated questionnaire laboratory examination. Cox regression models used for statistical analysis. 1040 cases diagnosed...
The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway plays a central role in transposon silencing and genome protection the animal germline. A family of Tudor domain proteins regulates piRNA through direct domain-PIWI interactions. domains are known to fulfill this function by binding methylated PIWI an arginine methylation-dependent manner. Here, we report mechanism methylation-independent interaction. Unlike most other domains, extended mammalian domain-containing...
Abstract The combination of immunotherapy and antiangiogenic agents for the treatment refractory solid tumor has not been well investigated. Thus, our study aimed to evaluate efficacy safety a new regimen anlotinib plus PD‐1 inhibitor treat tumor. APICAL‐RST is an investigator‐initiated, open‐label, single‐arm, phase II trial in patients with heavily treated, refractory, metastatic Eligible experienced disease progression during prior therapy without further effective regimen. All received...
Abstract Rationale: Extranodal natural killer T-cell lymphoma nasal type (ENKL) is an extremely rare tumor with a very low survival rate. In recent decades, only few ENKL cases have been published. Presenting special case lead the authors to emphasize primary features of in early diagnosis and therapy. Here we report unusual which was initially found eyes presented as masqueraded uveitis Patient concerns: A 55 years old female, vision loss right eye for approximately 6 months, blurry,...
Aging-related strength decline contributes to physiological deterioration and is a good predictor of poor prognosis. However, the mechanisms underlying neuromuscular junction disorders affecting contraction in aging are not well described. We hypothesized that autocrine effect interleukin (IL)-6 secreted by skeletal muscle inhibits acetylcholine receptor (AChR) expression, potentially causing aging-related decline. Therefore, we investigated IL-6 AChR β-subunit (AChR-β) expression muscles...
Melanoma is derived from melanocytes and accounts for ~80% of skin cancer-associated fatalities worldwide. The dysregulation microRNAs (miRNAs/miRs) involved in the development progression melanoma. Therefore, miRNAs may be novel diagnostic or prognostic biomarkers promising therapeutic targets treatment patients with miR‑675 differentially expressed several types human cancer has important roles pathogenesis diseases. However, expression levels biological melanoma remain unclear. present...
Early and accurate diagnosis of microorganism(s) is important to optimize antimicrobial therapy. Shotgun metagenomic sequencing technology, an unbiased comprehensive method for pathogen identification, seems potentially assist or even replace conventional microbiological methodology in the infectious diseases. However, evidence clinical application this platform relatively limited.To evaluate capability shotgun technology practice, both culture were performed PCR-positive body fluid...
A high-speed counter-current chromatography method is developed for the separation and purification of two triterpenoids from Chinese Uyghur medicinal plant Fomes officinalis ames.Crude were obtained ames through ethanol extraction.Preparative with two-phase solvent systems made up n-hexane-ethylacetatemethanol-water a volume ratio 1:1.5:1.2:1(v/v) was successfully performed in stepwise elution.The process yielded relatively pure single run 500 mg crude extract.The purities...
Dietary glycemic index (GI), carbohydrate to fiber ratio (CF) and quality (CQI) are conventional emerging indicators for quality. We aimed investigate the associations between these new-onset type 2 diabetes mellitus (T2DM) risk among Chinese adults. This prospective cohort study included 14,590 adults from China Health Nutrition Survey without cardiometabolic diseases at baseline. The dietary GI, CF CQI T2DM were assessed using Cox proportional hazard regression analysis dose–response...