A5065936273- Diet and metabolism studies
- Nutritional Studies and Diet
- Gut microbiota and health
- Dietary Effects on Health
- Probiotics and Fermented Foods
- Cancer, Stress, Anesthesia, and Immune Response
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Food composition and properties
- Diet, Metabolism, and Disease
- Immune Cell Function and Interaction
- Cancer survivorship and care
- Nutrition, Genetics, and Disease
- Selenium in Biological Systems
- SARS-CoV-2 and COVID-19 Research
- Obesity, Physical Activity, Diet
- Gastrointestinal motility and disorders
- Trace Elements in Health
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- COVID-19 Clinical Research Studies
- Tryptophan and brain disorders
- Heavy Metal Exposure and Toxicity
Sun Yat-sen University
2019-2024
Key Laboratory of Guangdong Province
2021-2023
Pennsylvania State University
2012-2021
Tufts University
2016-2020
Jean Mayer Human Nutrition Research Center on Aging
2016-2020
Abstract B cell response plays a critical role against SARS-CoV-2 infection. However, little is known about the diversity and frequency of paired antigen-specific BCR repertoire after Here, we performed single-cell RNA sequencing VDJ using memory plasma cells isolated from five convalescent COVID-19 patients, analyzed spectrum transcriptional heterogeneity antibody immune responses. Via linking to antigen specificity through (LIBRA-seq), identified distinct activated subgroup ( CD11c high...
Direct comparisons between SFAs varying in chain length, specifically palmitic acid (16:0) and stearic (18:0), relative to the latter–s metabolic product, oleic (18:1), on cardiometabolic risk factors are limited. The aim of this study was determine comparability diets enriched acid, inflammation coagulation markers, T lymphocyte proliferation/ex-vivo cytokine secretion, plasma factors, fecal bile concentrations. Hypercholesterolemic postmenopausal women (n = 20, mean ± SD age 64 7 y, BMI...
The long-term associations between dietary copper (Cu) and selenium (Se) intakes type 2 diabetes mellitus (T2DM) risk are unclear. We aimed to examine the prospective Cu Se T2DM in Chinese adults. A total of 14,711 adults from China Health Nutrition Survey (1997-2015) were included. Nutrient assessed by 3 consecutive 24 h recalls food-weighing methods. was identified a validated questionnaire laboratory examination. Cox regression models used for statistical analysis. 1040 cases diagnosed...
Background: Environmental and cardiometabolic impacts of adherence to plant-based dietary patterns with different quality are unclear. Objectives: To investigate the associations between overall, healthy, unhealthy patterns, as assessed by diet index (PDI), healthy PDI (hPDI), (uPDI), respectively, risk myocardial infarction (MI), type 2 diabetes (T2D), stroke, all-cause mortality greenhouse gas (GHG) emissions. Methods: Data from adults (N = 14,652 for diseases 15,318 mortality) in China...
Background: Current research inadequately substantiates the impacts of dietary inflammatory potential based on index (DII) population health and environmental sustainability in Chinese adults. Objectives: We aimed to investigate associations between DII with risk all-cause mortality greenhouse gas (GHG) emissions Methods: Data from adults (N = 15,318) China Health Nutrition Survey 1997–2015 wave were included analysis. energy-adjusted (E-DII) calculated using intake data collected a...
Scope Probiotics can modulate immunity and reduce upper respiratory tract infections (URTI) in humans; however few studies have examined both outcomes the same trial. The goal of current study was to investigate effect Bifidobacterium animalis subsp. lactis BB‐12, on natural killer (NK) T‐cell function conjunction with self‐reported cold/flu healthy adults. Methods results In a randomized, partially blinded, four‐period crossover study, adults ( n = 30) were recruited, received four...
Abstract Physical activity and the prevention of weight gain decrease breast cancer incidence improve survival. Unraveling biological mechanisms underlying these effects is difficult because dietary restriction are often linked. The goal this study was to determine whether physical (PA), preventing via energy (ER), or combination most effective in delaying tumor growth, reducing metastatic progression, improving survival 4T1.2 mammary model. Furthermore, we determined any interventions...
Obesity is associated with increased risk and reduced survival for many types of cancer. Increasing adiposity may affect the balance between immunosuppressive antitumor mechanisms critical dictating cancer progression or remission. The goal current study was to determine if altered tumor growth, survival, myeloid-derived suppressor cell (MDSC) accumulation in a subcutaneous murine model pancreatic C57BL/6 mice were placed on 30% kcal calorie-restricted diet, 10% from fat diet fed ad libitum,...
Men who have sex with men (MSM), a population bearing the greatest HIV burden in many countries, may also be vulnerable to COVID-19. COVID-19 vaccines are essential containing pandemic. However, vaccine hesitancy compromise coverage. We aimed understand uptake of and factors associated among HIV-infected MSM mainland China.A cross-sectional online survey was conducted between 13 21 February 2021 China. Variables including demographics, mental health status, characteristics, knowledge...
Some probiotics have hypocholesterolemic effects in animal studies, which are mediated, part, by increases fecal short chain fatty acids (SCFAs). Clinical trials of on lipids/lipoproteins inconsistent. We examined the Bifidobacterium animalis subsp. lactis BB-12® (BB-12®) (3.16 × 109 CFUs/day) lipids and lipoproteins excretion SCFAs healthy adults. In a randomized, partially blinded, 4-period, crossover study, 30 adults (11 men, 19 women) aged 18–40 years were randomly assigned to: 1) yogurt...
Available data investigating the associations between dietary animal and plant protein intakes cardiometabolic risk factors (CMRFs) among populations with habitual plant-based diets are heterogenous limited in scope. The current study was to assess CMRFs, including lipid lipoprotein profiles, glucose homeostasis biomarkers, low-grade chronic inflammatory biomarker uric acid Chinese adults. Data of 7886 apparently healthy adults were extracted from China Health Nutrition Survey 2009. Dietary...
The relationship between plasma copper concentration and prevalence of diabetes in adults with hypertension is unclear. We aimed to determine the association Chinese hypertension.A total 2,579 participants (697 cases 1,882 controls) was included this cross-sectional study. Plasma concentrations were determined by inductively coupled mass spectrometry. Multivariable logistic regression model used diabetes.According analyses, adjusted OR for ≥109.4 μg/dL 1.26 (1.00, 1.58) compared those <109.4...
We aimed to examine the effect of natto and red yeast rice (NR) supplementation on lipid lipoprotein profiles, gene expressions cholesterol metabolism, composition gut microbiota in ApoE-/- mice. Forty-one male mice aged 7–8 wks old were randomly fed a control diet (CD), CD + NR (oral gavage at 0.3 g/kg BW/day), high-fat high-cholesterol (HFD), or HFD for 12 wks. Fasting blood samples, liver intestine tissues fecal samples collected week 12. Biochemical parameters, metabolism diversity...
Probiotics are consumed in fermented dairy products or as capsules for their putative health benefits. However, little research has been done to evaluate the effects of delivery matrix on benefits probiotics humans. To examine delivering Bifidobacterium animalis subsp. lactis BB-12 (BB-12) (log10 10 ± 0.5 CFU/day) via a yogurt smoothie versus capsule, we monitored fecal microbiota, gut transit times (GTTs), and excretion short-chain fatty acids (SCFAs) healthy adults. In randomized,...