It is crucial to clarify the nonlinear effects of urban multidimensional characteristics on land surface temperature (LST). However, combined consideration green space (UGS), water bodies, buildings, and socio-economic factors limited. And diurnal differences in their thermal have been less considered. In this study, central Beijing was taken as study area. Local climate zones (LCZ) were firstly applied reveal spatiotemporal heterogeneity LST. Then, interpretable machine learning methods...

This paper describes a multidimensional spatial scan statistics approach to comparing movement patterns based on origin–destination (OD) representation. aims evaluate differences and similarities between the distributions of pair OD datasets, detect areas where two differ most. Specifically, datasets being compared are modeled as bivariate marked point process in space, consisting points representing individual records. Such space is formed by Cartesian product origins' destinations'...

Abstract Frustrated Lewis pairs (FLPs) present new opportunities for the development of highly active spinel materials activation stable molecules. Herein, a Ni and Co‐based with abundant FLPs sites (NiCo 2 O 4 ‐F) is synthesized through morphologic defect engineering used efficient catalytic ozonation CH 3 SH elimination. Characterization results reveal that NiCo ‐F nanoflower structure exposes more surface oxygen vacancies (Ov), inducing local charge redistribution forming regions. Ov acts...

Abstract Although previous studies have shown that transposable elements (TEs) are conservatively activated to play key roles during early embryonic development, the details of zygotic TE activation (ZTA) remain poorly understood. Here, we employ long-read sequencing precisely identify only a small subset loci among numerous copies, allowing us map their hierarchical transcriptional cascades at single-locus and single-transcript level. Despite heterogeneity ZTA across family, subfamily,...

Allergic diseases in children are major public health concerns due to their widespread and rising prevalence. Food-specific immunoglobulin G4(FS-IgG4) has been detected patients with allergic diseases, but its clinical significance is still debated. In the present study, 407 were recruited categorized into three groups according different systems involved: respiratory system group, skin a multiple collection of symptoms serum antibodies, including total E (IgE), house dust mite (HDM) IgE,...

Diends-azido-terminated and diends-alkynyl-terminated poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) triblock copolymers (N3-PEO-b-PPO-b-PEO-N3 HC≡C-PEO-b-PPO-b-PEO-C≡CH) were respectively prepared used together as the precursors for multiblock copolymer synthesis through coupling reaction by combination of self-assembly click chemistry. The equimolar resultant in water, a selective solvent PEO, results core−shell structure with insoluble collapsed PPO blocks core...

ABSTRACT Thiol–ene ultraviolet‐curable waterborne polyurethane (WPU) crosslinked networks capable of self‐healing cracks were developed for anticorrosion coating application. The healing mechanism is attributed to the rearrangement caused by triethylamine‐catalyzed thiol–disulfide exchange reaction proved high‐performance liquid chromatography, gel permeation and rheology tests. crack remendability can be repeated at least two times as demonstrated visual inspection. Moreover, effect was...

Available data investigating the associations between dietary animal and plant protein intakes cardiometabolic risk factors (CMRFs) among populations with habitual plant-based diets are heterogenous limited in scope. The current study was to assess CMRFs, including lipid lipoprotein profiles, glucose homeostasis biomarkers, low-grade chronic inflammatory biomarker uric acid Chinese adults. Data of 7886 apparently healthy adults were extracted from China Health Nutrition Survey 2009. Dietary...

OPINION article Front. Genet., 30 July 2019Sec. Genomic Medicine Volume 10 - 2019 | https://doi.org/10.3389/fgene.2019.00669

Hereditary angioedema (HAE) is a rare genetic disorder caused by deficiency or dysfunction of C1-esterase inhibitor that characterized recurrent episodes bradykinin-mediated edema. Lanadelumab has been the only available first-line therapy for long-term prophylaxis (LTP) HAE in China since its approval 2020. The present study aimed to investigate clinical efficacy and safety lanadelumab LTP Chinese patients.

Working memory is one of the most important functions in our brain, which has been widely studied with unreal-life measured technologies. A functional near-infrared spectroscopy (fNIRS) instrument a portable and low-cost design developed, capable providing hemodynamic measurement associated brain function real-life situations. Using this instrument, we performed working studies involved Chinese words encoding, verbal, spatial stem recognition, are mainly other Our results show that fNIRS can...

Abstract Quantifying the overall magnitude of every single locus’ genetic effect on widely measured human phenome is great challenge. We introduce a unified modelling technique that can consistently provide total contribution assessment (TGCA) gene or variant without thresholding association signals. Genome-wide TGCA in five UK Biobank phenotype domains highlights loci such as HLA locus for medical conditions, bone mineral density WNT16 physical measures, and skin tanning MC1R smoking...

Estimating the phenotypic correlations between complex traits and diseases based on their genome-wide association summary statistics has been a useful technique in genetic epidemiology statistical genetics inference. Two state-of-the-art strategies, Z-score correlation across null-effect single nucleotide polymorphisms (SNPs) LD score regression intercept, were widely applied to estimate correlations. Here, we propose an improved strategy SNPs with low minor allele frequencies (MAFs), show...

Surface pathogens in the ICU pose a global public health threat, especially to elderly patients who are immunocompromised. To detect these pathogens, unbiased methods such as metagenomic next-generation sequencing (mNGS) increasingly utilized for environmental microbiological surveillance.In six-month study from January July 2022, we investigated microbial communities Chinese geriatric ICUs by regularly monitoring multiple surfaces at three-month intervals. Using mNGS sequencing, analyzed...

Abstract In this study, we examined various alkylaluminums, including triethylaluminum (TEA), triisobutylaluminum (TIBA), and diethylaluminum chloride (DEAC), as cocatalysts for the activation of ethylene polymerizations in presence a fluorinated Fujita group invented titanium (FI‐Ti) catalyst, bis[ N ‐(3‐ tert ‐butylsalicylidene)‐2,3,4,5,6‐pentafluoroanilinato] titanium(IV) dichloride (complex 1 ). DEAC, because strong Lewis acidity, was an efficient cocatalyst activating complex...

To discuss effect of FK506 nanospheres used at different time on the regeneration allogeneic nerve after transplant.Single emulsion-solvent evaporation method (O/W) was adopted to prepare and tibial rats transplantation. were in group A operation immediately, B 24 h operation, C 3 d while not D; 4th, 8th 12th week respectively, general observation transplanted nerves, histological examination, image analysis myelinated fibers, wet-weight determination musculi triceps surae, retrogradely...

Adrenal aldosterone-producing adenoma (APA), producing the salt-retaining hormone aldosterone, commonly causes secondary hypertension, which often persists after unilateral adrenalectomy. Although persistent hypertension was correlated with residual in vivo mechanism remains unclear. NADPH oxidase is critical cause of aldosterone synthesis vitro . Nox2 and p22phox comprise catalytic core, serving to initiate a reactive oxygen species (ROS) cascade that may participate pathology. mRNAs seven...

Estimating the phenotypic correlations between complex traits and diseases based on their genome-wide association summary statistics has been a useful technique in genetic epidemiology statistical genetics inference. Two state-of-the-art strategies, Z-score correlation across null-effect SNPs LD score regression intercept, were widely applied to estimate correlations. Here, we propose an improved strategy with low minor allele frequencies (MAFs), show how this simple can correct bias...

Obesity has a highly complex genetic architecture, making it difficult to understand the mechanisms, despite large number of discovered loci via genome-wide association studies (GWAS). Omics techniques have provided better resolution view this problem. As proxy cell-level biology, extracellular vesicles (EVs) are useful for studying cellular regulation phenotypes such as obesity. Here, in well-established Scottish cohort, we utilized novel technology detect surface proteins across millions...

<title>Abstract</title> Background Hereditary angioedema (HAE) is a rare genetic disorder caused by deficiency or dysfunction of C1 esterase inhibitor (C1-INH), which leads to recurrent episodes bradykininmediated edema. Lanadelumab plasma kallikrein that the only first line therapy for long term prophylaxis (LTP) HAE attacks in China since 2021. Objectives To observe clincial efficacy and safety lanadelumab Chinese patients with small population four patients. Method Four from three...