A5020894983- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- RNA modifications and cancer
- Signaling Pathways in Disease
- Muscle activation and electromyography studies
- Gut microbiota and health
- Animal Virus Infections Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Virus-based gene therapy research
- Diet and metabolism studies
- Medical Imaging and Pathology Studies
- Nuclear Receptors and Signaling
- Muscle Physiology and Disorders
- Viral gastroenteritis research and epidemiology
- Exercise and Physiological Responses
- Calpain Protease Function and Regulation
- Lipid metabolism and biosynthesis
- MicroRNA in disease regulation
- Vitamin C and Antioxidants Research
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Pain Mechanisms and Treatments
University of Chinese Academy of Sciences
2017-2025
Shanghai Institute of Nutrition and Health
2018-2025
Shanghai Institutes for Biological Sciences
2017-2019
Center for Excellence in Molecular Cell Science
2017-2019
Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and 2 diabetes, but any treatment toward development of DPN not yet available. Axon degeneration an early feature many neuropathies, including DPN. Delay axon has beneficial effects on various neurodegenerative diseases, its effect to be elucidated. Deficiency Sarm1 significantly attenuates several models, deficiency still unclear. In this study, we show that knockout mice exhibit normal glucose metabolism...
Abstract Nicotinamide mononucleotide adenylyltransferase 2 ( Nmnat2 ) plays an important role in maintaining axon integrity, and the arcuate nucleus (ARC), paraventricular (PVN) are crucial nuclei control of energy balance. However, effect deficiency ARC PVN is still unclear. loxP/loxP or , Sarm1 −/− mice were bilaterally injected with AAV‐CMV‐GFP‐Cre once into ARC, PVN, lateral parabrachial (LPBN) to obtain ARC−/− PVN−/− LPBN−/− SKO mice. Syn1‐Cre AAV‐EF1a‐flex‐taCasp3‐TEVp specifically...
Abstract Small RNAs (sRNAs) within 15-30 nt such as miRNA, tsRNA, srRNA with 3’-OH have been identified. However, whether these sRNAs are the major is still unknown. Here we show about 90% mammalian end 2’,3’-cyclic phosphate (3’-cP). TANT-seq was developed to simultaneously profile 3’-cP (sRNA-cPs) and sRNA-OHs, huge amount of sRNA-cPs were detected. Surprisingly, sRNA-OHs usually distinct sequences. The data from validated by a novel method termed TE-qPCR, Northern blot. Furthermore, found...
Abstract Obesity and diabetes are risk factors for hepatocellular carcinoma (HCC); however, the underlying mechanisms yet to be elucidated. Adeno‐associated virus (AAV) frequently infects humans has been widely used in gene therapy, but of AAV infection such as HCC should further evaluated. Here, we show that recombinant injection caused liver injury, hepatic necroptosis, db/db or high‐fat diet‐induced hyperglycemic obese mice, not mice with only hyperglycemia obesity. Prednisone...
Background: Sustained inflammation is implicated in a variety of pathological conditions like infection, obesity and type 2 diabetes. Lipid metabolism crucial to support immune response during infection bacteria. However, how sustained affects lipid metabolism, especially white adipose tissue remains largely unknown. Methods: was induced by daily injection Lipopolysaccharide (LPS). Tlr4 knockout mice were used study the mechanism. Inflammation evaluated quantitative PCR, blood cell counting,...
Short-term tamoxifen treatment has effects on lipid and glucose metabolism in mice fed chow. However, its high-fat diet (HFD) the underlying mechanisms are unclear. Here, we show that for 5 days decreases fat mass as long 18 weeks HFD. Tamoxifen alters mRNA levels of some genes involved white adipose tissue improves insulin tolerance well hepatic signaling 12-20 weeks. Proopiomelanocortin (POMC) neuron-specific deletion nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) attenuates...
Aging-related strength decline contributes to physiological deterioration and is a good predictor of poor prognosis. However, the mechanisms underlying neuromuscular junction disorders affecting contraction in aging are not well described. We hypothesized that autocrine effect interleukin (IL)-6 secreted by skeletal muscle inhibits acetylcholine receptor (AChR) expression, potentially causing aging-related decline. Therefore, we investigated IL-6 AChR β-subunit (AChR-β) expression muscles...
Hemin is a breakdown product of hemoglobin. It has been reported that the injection hemin improves lipid metabolism and insulin sensitivity in various genetic models. However, effect supplementation food on still unclear, whether directly affects cellular yet to be elucidated. Here we show enhances insulin-induced phosphorylation receptors, Akt, Gsk3β, FoxO1 cytoplasmic translocation cultured primary hepatocytes under insulin-resistant conditions. Furthermore, diminishes accumulation...
AASLD Publications Hepatology Liver Transplantation Clinical Disease Communications