A5014836492- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Eosinophilic Disorders and Syndromes
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Viral-associated cancers and disorders
- Peptidase Inhibition and Analysis
- Acute Lymphoblastic Leukemia research
- Protein Degradation and Inhibitors
- Blood groups and transfusion
- Ocular Diseases and Behçet’s Syndrome
- HER2/EGFR in Cancer Research
- Restless Legs Syndrome Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- CNS Lymphoma Diagnosis and Treatment
- Complement system in diseases
- Toxin Mechanisms and Immunotoxins
- Immunodeficiency and Autoimmune Disorders
- Hemoglobinopathies and Related Disorders
- Hepatitis B Virus Studies
- Cutaneous lymphoproliferative disorders research
Istanbul University-Cerrahpaşa
2016-2025
Istanbul University
2012-2024
Sağlık Bilimleri Üniversitesi
2022
Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi
2022
Background:The standard conditioning regimen for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) is 200 mg/m 2 of melphalan (Mel200).Dosing reduced by 30% (Mel140) frail patients.Studies comparing the performance these regimens report inconsistent findings, mainly confounded non-consecutive patient inclusion, missing data, and heterogenous practices.The largest study reported an increased risk death with Mel200 among patients very good partial remission, or better,...
Abstract In advanced-stage classical Hodgkin lymphoma (cHL), the prognosis has improved due to combination chemotherapy and PET/CT-guided treatment modification, resulting in a decreased prognostic capacity of IPS models. A novel model, A-HIPI, was found be superior predicting prognosis. this study, we aimed validate A-HIPI model among Turkish cHL patients compare its performance with other clinical prediction We retrospectively evaluated diagnosed between 2005 2018 at Istanbul...
Abstract Introduction Therapeutic plasma exchange (TPE) may involve complications. We aimed to review the demographic data, indications, technical information, and Methods Data for TPE procedures (TPEPs) performed between 2004 2018 were retrospectively. Results This study covered 2505 TPEPs on 338 patients; 55% of them female ( n = 186), median age was 36 years (range, 11–93 years). Most administered hematological (40.6%) indications. The incidence complications first procedure 3.2% 80);...
Current treatment modalities can cure up to 70–80 % of patients with classical Hodgkin lymphoma. Approximately, 20–30 require further options. Brentuximab vedotin has been approved for the relapsed and refractory In present study, we report experience brentuximab as single agent in 58 or The objective response rate was 63.5 13 complete responders (26.5 %) among 49 evaluated at early phase (2–5 cycles). Upon prolongation (≥6 cycles), 37 achieved a final 32.4 21.6 10.8 partial response....
Objective: here have been tremendous changes in treatment and follow-up of patients with chronic myeloid leukemia (CML) the last decade.Especially, regular publication updating NCCN ELN guidelines provided enermous rationale base for close monitorization CML.But, it is stil needed to registry results retrospectively evaluate daily CML practices.
Abstract Myelodysplastic syndrome (MDS) represents a heterogeneous group of potentially malignant diseases bone‐marrow stem cells. Acute myelogenous leukaemia (AML) is an inevitable outcome for many patients with MDS. Azacitidine has been reported to result in comparably higher response rates and improved survival than other treatment strategies. In this retrospective study, we report the results on 25 ‘real life’ MDS, CMML or AML treated azacitidine between 2005 2009. All fulfilled World...
Patients receiving hematopoietic stem cell transplantation (HSCT) are exposed to highly immunosuppressive conditions and bloodstream infections (BSIs) one of the most common major complications within this period. Our aim, in study, was evaluate epidemiology BSIs these patients retrospectively.The epidemiological properties 312 with HSCT were retrospectively evaluated.A total patients, followed between 2000 2011, who underwent autologous (62%) allogeneic (38%) included study. The underlying...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare malignancy with skin tropism.The entity was recently defined and the diagnosis generally made by biopsies.It necessary to apply appropriate immunohistochemistry recognize this entity.There no consensus on therapy survival rates are low.The aim of study describe clinical histopathological features BPDCN.We retrospectively reviewed 8 BPDCN cases Cerrahpaşa Medical Faculty diagnosed between 2005 2019.We documented findings,...
Tyrosine kinase inhibitor (TKI) therapy is the current treatment of choice for patients with chronic phase myeloid leukemia (CML) leading to rapid and durable hematological as well molecular responses. However, emergence resistance TKIs has been major obstacle success on long term. In this regard domain mutations are most common mechanism failure. study, we analyzed peripheral blood samples from 17 CML who had developed various by using next-generation sequencing parallel Sanger sequencing....
The aim of this single-center, retrospective study was to investigate the impact rituximab, reconsider validity International Prognostic Index (IPI), and evaluate prognostic role cell origin (CoO) in a relatively young cohort. Three hundred twelve diffuse large B lymphoma patients (median age: 52) were included. Rituximab significantly improved 3- 5-year progression free survival (PFS) (70% versus 65% 41% 36%, resp.; P < 0.001) but led only slight, insignificant increase overall (OS) (71%...
Summary Multiple myeloma (MM) is a haematological malignancy primarily affecting the elderly, with striking male predilection and ethnic disparities in incidence. Familial predisposition to MM has long been recognized, but genetic underpinnings remain elusive. This study aimed investigate germline variants Turkish families recurrent cases. A total of 37 MM‐affected families, comprising 77 individuals, were included. Targeted next‐generation sequencing analysis yielded no previously reported...
Objectives This study has been conducted to investigate the non-invasive diagnostic journey of patients with a transthyretin amyloid cardiomyopathy (aTTR-CM) in Turkey, identify challenges and uncertainties encountered on path diagnosis from perspectives expert physicians, develop recommendations that can be applied such cases. Methods employed three-round modified Delphi method included 10 cardiologists five nuclear medicine specialists. Two hematologists also shared their opinions survey...
In this study, we retrospectively analyzed the clinical outcome, treatment responses, infectious complications, and survival rates of 71 hairy cell leukemia (HCL) cases.