A5025454810- Dialysis and Renal Disease Management
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Renal Transplantation Outcomes and Treatments
- Parathyroid Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Atherosclerosis and Cardiovascular Diseases
- Muscle and Compartmental Disorders
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Lipoproteins and Cardiovascular Health
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Function and Risk Factors
- Organ Donation and Transplantation
- Body Composition Measurement Techniques
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Diabetes Treatment and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin D Research Studies
- Electrolyte and hormonal disorders
- Acute Kidney Injury Research
Ege University
2013-2024
Pediatric Nephrology of Alabama
1997-2015
St James's University Hospital
2013
Medical University of Vienna
2013
University of Arkansas for Medical Sciences
2005-2013
Fresenius Medical Care (Germany)
2011
Emory University
2011
Haga Hospital
2011
Central Arkansas Veterans Healthcare System
2005-2007
University of Thessaly
2007
Mortality rates remain high for haemodialysis (HD) patients and simply increasing the HD dose to remove more small solutes does not improve survival. Online haemodiafiltration (HDF) provides additional clearance of larger toxins compared with standard HD. Randomized controlled trials (RCTs) comparing HDF conventional on all-cause cause-specific mortality in end-stage kidney disease (ESKD) reported inconsistent results were at risk bias. We conducted a pooled individual participant data...
The general objective assigned to the EUropean DIALlysis (EUDIAL) Working Group by European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) was enhance quality of dialysis therapies in Europe broadest possible sense. Given increasing interest convective therapies, has started focusing on haemodiafiltration (HDF) therapies. Several reports suggest that those potentially improve outcomes for end-stage renal disease patients. is leader field, having introduced concept...
Background.Vascular calcification (VC), mainly due to elevated phosphate levels, is one major problem in patients suffering from chronic kidney disease.In clinical studies, an inverse relationship between serum magnesium and VC has been reported.However, there only few information about the influence of on a cellular level available.Therefore, we investigated effect induced by b-glycerophosphate (BGP) bovine vascular smooth muscle cells (BVSMCs).Methods.BVSMCs were incubated with media for...
Chronic fluid overload (FO) is frequently present in peritoneal dialysis (PD) patients and associated with hypertension left ventricular hypertrophy dysfunction, which are important predictors of death patients. In the study, we investigated relationship between nutrition, inflammation, atherosclerosis body volumes measured by multi-frequency bioimpedance analysis (m-BIA) PD addition, analysed extracellular volume values m-BIA to echocardiographic parameters order define its usefulness as a...
Exposure to high Ca concentrations may influence the development of low–turnover bone disease and coronary artery calcification (CAC) in patients on hemodialysis (HD). In this randomized, controlled study, we investigated effects lowering dialysate level progression CAC histologic abnormalities HD. Patients HD with intact parathyroid hormone levels ≤300 pg/ml receiving containing 1.75 or 1.50 mmol/L ( n =425) were randomized 1.25-mmol/L (1.25 Ca; =212) 1.75-mmol/L (1.75 =213) arm. Primary...
ObjectiveIn patients with advanced kidney disease, metabolic and nutritional derangements induced by uremia interact reinforce each other in a deleterious vicious circle. Literature addressing the effect of dialysis initiation on changes body composition (BC) is limited contradictory. The aim this study was to evaluate BC large international cohort incident hemodialysis patients.MethodsA total 8,227 adult end-stage renal disease evaluation within initial first 6 months baseline, defined as...
Carbamylated low-density lipoprotein (LDL), the most abundant modified LDL isoform in human blood, has been recently implicated causing atherosclerosis-prone injuries to endothelial cells vitro and atherosclerosis humans. This study was aimed at testing hypothesis that carbamylated acts via inducing monocyte adhesion determining molecules responsible for recruitment of monocytes.Exposure coronary artery with but not native caused U937 induction intercellular molecule-1 vascular cell as...
Low serum testosterone levels in hemodialysis (HD) patients have recently been associated with cardiovascular risk factors and increased mortality. To confirm this observation, we investigated the predictive role of total on mortality a large group male HD from Turkey.A 420 prevalent were sampled March 2005 followed up for all-cause Serum measured by ELISA at baseline studied relation to profile.Mean level was 8.69 ± 4.10 (0.17 27.40) nmol/L. A proportion (66%) had deficiency (<10 nmol/L)....
Background. Vascular calcifications are frequent in Stage 5 chronic kidney disease (CKD-5) patients receiving haemodialysis. The current study was designed to evaluate the associations between bone turnover/volume and coronary artery (CAC). Methods. In 207 CKD-5 patients, biopsies, multislice computed tomography of arteries blood drawings for relevant biochemical parameters were done. large number enrolled allowed separate evaluation with CAC versus without adjustment traditional...
Background and objectives End-stage renal disease is linked to alterations in thyroid hormone levels and/or metabolism, resulting a high prevalence of subclinical hypothyroidism low triiodothyronine (T3) levels. These are involved endothelial damage, cardiac abnormalities, inflammation, but the exact mechanisms unclear. In this study, we investigated relationship between serum free-T3 (fT3) carotid artery atherosclerosis, arterial stiffness, vascular calcification prevalent patients on...
<i>Background:</i> Serum free triiodothyronine (fT3) level is suggested to be a risk factor for mortality in unselected dialysis patients. We investigated the prognostic value of serum fT3 levels and also low-T3 syndrome on overall survival large cohort hemodialysis (HD) patients with normal thyroid-stimulating hormone levels. <i>Methods:</i> A total 669 prevalent HD were enrolled study. was measured by enzyme immune assay frozen sera samples at time enrollment....
We investigated the claim that infusion of albumin potentiates diuretic effect frusemide in patients with nephrotic syndrome.1 We selected 12 inpatients syndrome according to two criteria: (a) failure lose weight after bed rest and a 40 mmol sodium diet (b) presence minimal lesions or well preserved glomerular histology on renal biopsy. gave each patient three treatments randomly from 8 am noon, at intervals least days—infusion 0.5 g/kg given as 20% solution for four hours; 60 mg bolus...
Some intestinal parasitic infections are frequently seen in renal transplant recipients. Parasites such as Cryptosporidium spp. and Blastocystishominis often asymptomatic or responsible for limited normals, but may cause prolonged heavy with gastrointestinal complaints, mainly diarrhea, immunocompromised patients. Such can not be detected by routine diagnostic procedures, special concentration staining methods needed. We investigated 115 fecal specimens from 69 recipients 42 control cases....
Abstract Background: We previously suggested that increased carbamylated LDL (cLDL), a product of nonenzymatic modification in human serum by urea-derived cyanate, may cause cardiovascular complications patients with chronic renal insufficiency. An assay for precise measurement cLDL was not available. Methods: Polyclonal antibodies against and nonmodified, native (nLDL) were raised rabbits extensively purified affinity chromatography. New sandwich ELISAs to measure nLDL use these developed....
Presence of accelerated atherosclerosis in dialysis patients cannot be entirely explained by conventional risk factors. Exposure to urea, which is elevated with kidney disease, leads the carbamylation proteins. We investigated effects carbamylated low-density lipoprotein (cLDL) on human coronary artery vascular smooth muscle cells (VSMC).Native LDL (nLDL) was potassium cyanate. Cells were incubated different concentrations cLDL at time points. Cytotoxicity, apoptosis, proliferation...
Demirci MS, Toz H, Yılmaz F, Ertilav M, Asci G, Ozkahya Zeytinoglu A, Nart D, Ok E. Risk factors and consequences of post‐transplant diabetes mellitus. Clin Transplant 2010 DOI: 10.1111/j.1399‐0012.2010.01247.x. © John Wiley & Sons A/S. Abstract: Background: The aim this study is to investigate the clinical course as well risk prognosis mellitus (PTDM). Methods: Five hundred fifty‐five kidney transplant recipients were retrospectively evaluated. PTDM was defined fasting blood glucose...