A5010860501- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Tissue Engineering and Regenerative Medicine
- Renal and related cancers
- Advanced biosensing and bioanalysis techniques
- Telomeres, Telomerase, and Senescence
- Ureteral procedures and complications
- Sepsis Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Interdisciplinary Research and Collaboration
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Long-Term Effects of COVID-19
- Gold and Silver Nanoparticles Synthesis and Applications
- Urinary and Genital Oncology Studies
- Advanced Nanomaterials in Catalysis
- Dermatologic Treatments and Research
- interferon and immune responses
- Immune cells in cancer
- 14-3-3 protein interactions
- Radio Frequency Integrated Circuit Design
- Photosynthetic Processes and Mechanisms
- Electrochemical sensors and biosensors
Hacettepe University
2018-2024
The University of Texas Southwestern Medical Center
2024
Southwestern Medical Center
2024
Bielefeld University
2022
Spanish National Cancer Research Centre
2022
Heinrich Heine University Düsseldorf
2019-2020
Ege University
2017
Memorial Sisli Hospital
2016
Rijnstate Hospital
2011
The heterogeneity and metastatic features of cancer cells lead to a great number casualties in the world. Additionally, its diagnosis as well treatment is highly expensive. Therefore, development simple but effective diagnostic systems which detect molecular markers importance. changes on cell membranes serve targets, such HER2/neu receptor detected surface breast cells. We have aimed develop specific quartz crystal microbalance (QCM)-based system identify expressing via receptor-specific...
The histone demethylase Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked (UTX/KDM6A) demethylates H3K27me2/3 at genes and enhancers is often inactivated by mutations in urothelial carcinoma (UC). consequences of its inactivation are however poorly understood. We have investigated the moderate UTX overexpression across a range UC cell lines with or without KDM6A interaction partners normal control line. Effects on proliferation, especially long-term, varied dramatically...
Abstract The BRAF gene is frequently mutated in cancer. most common genetic mutation a single nucleotide transition which gives rise to constitutively active kinase (BRAF V600E ) turn sustains continuous cell proliferation. study of murine models has been mainly focused on the role tumor development but little known early molecular impact expression vivo. Here, we immediate effects acute ubiquitous activation We find that elicits rapid DNA damage response liver, spleen, lungs not thyroids....
More than 95,000 protein-protein interactions of Arabidopsis thaliana have been published and deposited in databases. This dataset was supplemented by approximately 900 additional interactions, which were identified the literature from years 2002-2021. These used as basis for a Cytoscape network with data on subcellular localization, gene ontologies, biochemical properties co-expression. The resulting has exemplarily applied unraveling PPI-network plant vacuolar proton-translocating ATPase...
The histone demethylase UTX (gene: KDM6A) directs cell and tissue differentiation during development. Deleterious mutations in KDM6A occur many human cancers, most frequently urothelial carcinoma. consequences of these are poorly understood; plausibly, they may disturb differentiation. We therefore investigated the effects siRNA-mediated knockdown two vitro models differentiation; namely, primary cultures epithelial cells treated with troglitazone PD153035 immortalized line HBLAK high...
Regular exercise is known to reduce incidence rates and improve the prognosis of all cancers, but underlying mechanisms remain elusive. Ample evidence suggests that exerts therapeutic effects through extracellular vesicles (EVs), essential for cellular communication. Here, we hypothesized exercise-induced EVs from serum healthy young male participants will exert anti-tumorigenic on human colon cancer HT-29 cells, in an intensity-dependent manner. 10 active males (25.4±6.2yrs, with maximal...
Telomerase and telomeres are crucial in cancer cell immortalization, making them key targets for anticancer therapies. Currently, 6-thio-dG combined with the anti-PD1 inhibitor Cemiplimab is under Phase 2 clinical investigation (NCT05208944) NSCLC patients resistant to prior immunotherapies. This study presents design, synthesis, evaluation of novel bimodular conjugate molecules combining telomere-targeting nucleoside analogs phosphatidyl diglyceride groups. Among them,...
Telomerase and telomeres are crucial in cancer cell immortalization, making them key targets for anticancer therapies. Currently, 6-thio-dG (THIO) combined with the anti-PD-1 inhibitor Cemiplimab is under phase II clinical investigation (NCT05208944) NSCLC patients resistant to prior immunotherapies. This study presents design, synthesis, evaluation of novel bimodular conjugate molecules combining telomere-targeting nucleoside analogs phosphatidyl diglyceride groups. Among them,...
In this video, our technique of robotic intracorporeal Studer pouch construction, specifically emphasizing suturing and stenting techniques, is presented. A 63 year-old female patient with muscle invasive bladder cancer was referred to hospital for radical cystectomy Studer-pouch construction. Her pathological stage prior T1GIII in the endoscopic examination, tumor found have spread all over mucosa. past medical history revealed a laparoscopic cholecystectomy 20 years ago cesarean section 30 ago.
This article presents our surgical technique on robotic cystectomy preserving female genitalia. A 59 year-old patient with muscle invasive bladder cancer was referred to hospital for radical and intracorporeal Studer-pouch construction. An incomplete trans urethral resection of the performed 2 months earlier at a peripheral pathological examination revealed invasive, high-grade papillary urothelial carcinoma (T2GIII). She had undergone two open abdominal surgeries (appendectomy cesarean...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Introduction: The most common way of ureteric catheter placement is passing it through the anterior abdominal wall.1–3 Since forms a bridge between wall and ileal segment, might cause looping bowel segments around them. Here we describe our alternative technique placing double J stent (DJS) at time robotic radical cystectomy total intracorporeal Studer-pouch construction, which can also be applied to open surgery. Patient Method: Robotic construction were planned on 73-year-old man with...
Abstract We report the rare occurrence of bilateral low‐grade MALT lymphoma breast in a 73 year old female. The clinical, pathological and treatment details are discussed, with review literature.
research institutions.At the end of their Ph.D. training, publishing 3 scientific papers