A5054537848- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Diet, Metabolism, and Disease
- Pesticide Exposure and Toxicity
- Metabolism and Genetic Disorders
- Biochemical Acid Research Studies
- Medicinal Plants and Neuroprotection
- Effects and risks of endocrine disrupting chemicals
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Free Radicals and Antioxidants
- Advanced Glycation End Products research
- Healthcare Systems and Technology
- Nicotinic Acetylcholine Receptors Study
- Chronic Kidney Disease and Diabetes
- Cancer-related cognitive impairment studies
- Photodynamic Therapy Research Studies
- Fatty Acid Research and Health
- Nerve injury and regeneration
- Advanced Differential Geometry Research
- Dermatoglyphics and Human Traits
- Interdisciplinary Research and Collaboration
- Phytoestrogen effects and research
- Transcranial Magnetic Stimulation Studies
- Heavy Metal Exposure and Toxicity
Muğla University
2022-2025
Hacettepe University
2014-2024
Hebrew University of Jerusalem
2022
GATA Haydarpaşa Eğitim Hastanesi
2003
Abstract Butyrylcholinesterase is an abundant detoxification enzyme in human serum that mainly synthesized the liver. It plays a crucial role hydrolysis of variety choline esters and xenobiotics, there emerging evidence it also involved lipid metabolism. In this study, inhibitory effects major unsaturated fatty acids — arachidonic acid (AA), linoleic (LA), oleic (OA), alpha-linolenic (α-LA) on BChE are investigated using kinetics experiments molecular modeling analyses. These acids, integral...
Di (2-ethylhexyl) phthalate (DEHP) is used as plasticizer in the industry and belongs to family which can induce tissue damage including kidney, liver, testis a result of elevated oxidative stress levels. Glutathione reductase (GR), Glucose-6-phosphate dehydrogenase (G6PD), glutathione S-transferase (GST), 6-phosphogluconate (6PGD), enzyme activities, trace element mineral levels were evaluated brain samples. Our data revealed that, antioxidant activities samples statistically insignificant...
This study investigated the effects of flaxseed (Linum usitatissimum L.) intake on general metabolism, pentose phosphate pathway (PPP) and glutathione-dependent enzymes in diabetic rats. Diabetes was induced by streptozotocin injection (40 mg/kg, i.p.) enzyme activities were determined spectrophotometrically. Diabetic control rats divided two subgroups, one untreated, treated with (0.714 g/kg body weight/day; orally) for 12 weeks. Flaxseed ameliorated decreased weight (p < .05) increased...
Acetylcholinesterase and butyrylcholinesterase (AChE BChE) are involved in modulating cholinergic signaling, but their roles Alzheimer’s Parkinson’s diseases (AD PD) remain unclear. We identified a higher frequency of the functionally impaired BCHE-K variant (rs1803274) AD PD compared to controls lower than GTEx dataset healthy individuals ( n = 651); comparison, prevalence 5′-UTR (rs1126680) intron 2 (rs55781031) single-nucleotide polymorphisms (SNPs) BCHE ACHE’s 3′-UTR (rs17228616) which...
The pentose phosphate pathway and glutathione-associated metabolism are the main antioxidant cellular defense systems. This study investigated effects of powerful SMe1EC2 (2-ethoxycarbonyl-8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b] indolinium dichloride) on (PPP) glutathione-dependent enzyme activities in aged diabetic matched control rats. Diabetes was induced by streptozotocin injection rats 13-15 months. Diabetic were divided into two subgroups, one untreated treated with (10...
The study aimed to investigate whether timolol-treatment has a beneficial effect on pentose phosphate pathway enzyme activities such as glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate (6PGDH) and cAMP level in streptozotocin-induced diabetic rats pancreatic tissues.Diabetes was induced by streptozotocin (STZ) 3-month old male Wistar rats. were treated with timolol (5 mg/kg body weight, for 12 weeks) while the control group received saline. Enzyme determined pancreas tissue. To...
Cisplatin (Cis) is a chemotherapeutic agent that has many side effects. Neurotoxicity one of the most important these Oxidative stress and neuroinflammation are best-known mechanisms in pathogenesis neurotoxicity development. In this study, we aimed to determine whether melatonin (Mel), with antioxidant anti-inflammatory effects, effective preventing Cis-induced neurotoxicity. Forty-eight male Sprague-Dawley rats were divided into six groups (n = 8) as follows: control (0.9% NaCl), vehicle...
Phenylketonuria (PKU) results from congenital defects of amino acid metabolism. Accumulated phenylalanine crosses the blood-brain barrier and causes permanent brain damage, but neuro-pathophysiology underlying phenylketonuria is not fully understood. Chemically-induced rat model both genders was generated to examine role inflammatory response, lipid peroxidation oxidative stress in prefrontal cortex. Our showed that there an increase compared controls, which significantly different only...
Introduction: Phenylketonuria (PKU) is a rare inherited metabolic disorder characterized by deficiency of the enzyme phenylalanine hydroxylase. The absence this leads to elevated levels in blood, causing accumulation brain and resulting permanent damage. To investigate neurological effects PKU, an experimental PKU model was developed, cholinergic parameters were analyzed tissue serum from both female male rats. Serum AChE, BChE, total ChE activities examined, while AChE activity specifically...
Purpose To evaluate matrix metalloprotease-1 (MMP-1), metalloprotease-3 (MMP-3), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in the eyelid skin fibroadipose tissue patients with inactive moderate-to-severe Graves' orbitopathy (GO).
research institutions.At the end of their Ph.D. training, publishing 3 scientific papers