Paraoxonase-1 (PON1) is an antioxidant enzyme located in high density lipoprotein (HDL). PON1 was defined as a protective factor against atherosclerosis. The aim of this study to investigate the possible relationship between serum paraoxonase (PONase), homocysteine thiolactonase (HTase) activities and Q192R polymorphism, extent severity atherosclerosis.Blood specimens were collected from 142 individuals who had no coronary artery lesions angiographically (control group) 128 documented...

Organophosphate (OP) compounds are the most commonly used pesticide groups and they commercially in market for local industrial purposes. Paraoxonase 1 (PON1) enzyme plays an important role biotransformation of OP compounds, which shows toxic effects via inhibiting acetylcholinesterase (AChE). The aim this study was to determine PON1 gene polymorphism its on PON AChE activities individuals who were exposed organophosphorus insecticides due occupational reasons, profile probability...

Objective: Paraoxonase1 (PON1), exhibits both esterase activity (PON1-AREase) and homocysteine thiolactonase (PON1-HTLase) which respectively prevent LDL oxidation detoxify thiolactone (HTL). Platelet-activating factor-acetylhydrolase (PAF-AH) is an antioxidant enzyme preventing by hydrolysis of oxidized phospholipids. Both these enzymes exhibit a proatherogenic role. ADMA endogenous inhibitor nitric oxide (NO) synthesis causing endothelial dysfunction. The aim was to compare non-obese PCOS...

IMA and MPO are elevated in serum case of end-stage renal disease. Epicardial fat tissue thickness has been considered an indicator for cardiovascular diseases recently. The present study was aimed to examine the relationship epicardial (EFTT) with levels patients CKD.Predialysis CKD admitted Nephrology outpatient clinic, on haemodialysis healthy volunteers were included, 111 study. EFTT measurement performed transthoracic view using ECHO device.The analysis conducted among groups terms IMA,...

Covid-19 is a pandemic viral infection with high pathogenicity and contagiousness. Our aim to evaluate the preliminary hematological findings analyzed during admission in order determine diagnostic value of parameters patients reveal their relationship severity disease.Our study includes total 169 patients, whose diagnosis was confirmed 93 whom were treated ward, 76 Intensive Care Unit (ICU), 67 control patients. Neutrophil-to-lymphocyte ratio (NLR), monocyte-lymphocyte (MLR) ratio,...

Along with vitamin D deficiency, a common global health problem in developed and developing countries, zinc deficiency also remains one of the most micronutrient deficiencies-related public problems some parts world. Determination Zn status is important for growth, development, school-age children, as well their intellectual achievement academic performance. In this study, we aimed to evaluate serum 25(OH)D levels relationship between them nationally representative sample Turkish children...

Background: Coronavirus disease 2019 (COVID-19) is a systemic which causes an increased inclination to thrombosis by leading coagulation system activation and endothelial dysfunction. Our objective in this study determine whether ischemia-modified albumin (IMA) can be used as new marker patients with COVID-19 for evaluating the risk, pneumonic infiltration, thus, prognosis. Methods: included 59 compatible infiltration on lung computed tomography (CT) who applied were hospitalized Internal...

Abstract The aim of the study was to measure platelet‐activating factor acetyl hydrolase (PAF‐AH) and paraoxonase (PON1) enzyme activity levels in patients with high Psa values compare healthy peers also determine efficacy these parameters predicting pathologic results values. This included 66 value > 4 ng/dl (Group 1) 44 <4 2) for a total 110 patients. Parameters measured serum PON1, PAF‐AH, MDA were compared between groups. Additionally same prostate biopsy performed due diagnosed...

Background: Several studies have investigated the effects of cardiac resynchronization therapy (CRT) on heart failure (HF), but none evaluated pathophysiological pathways involved in a single group patients. Therefore, this study aims to assess long-term CRT six different patho­physiological process HF by use surrogate biomarkers. Methods: In 44 patients with HF, groups biomarkers were measured, both at baseline and 1 year after implantation: inflammation (interleukin [IL]-4, IL-6, tumor...

Objective Cardiac resynchronization therapy (CRT) induces structural and electrical reverse remodeling of the failing heart. However, association between native QRS narrowing cardiac fibrosis markers has not been investigated in patients with an implanted CRT device. Methods A total 41 symptomatic diagnosed systolic heart failure who underwent implantation were included this study. Electrocardiogram findings marker levels [galectin-3, growth-differentiation factor-15 (GDF-15) procollagen III...

The aim of this study was to examine the relationship between vitamin D levels in patients with heart failure (HF) and response cardiac resynchronization therapy (CRT).We studied 57 (mean age: 60.47±13.09 years) New York Heart Association Class II or III failure, QRS duration ?120 milliseconds, ejection fraction <35% (mean: 27.1±4.4%) who underwent CRT. All were taking optimal medical treatment for HF. Patients classified as CRT responders if they had >15% decrease left ventricular...

<b>Background and Objective</b> Mechanical ventilation (MV) can induce oxidative stress, which plays a critical role in pulmonary injury intubated neonates. Ischemia-modified albumin (IMA)—a variant of human serum albumin—is novel biomarker myocardial ischemia that occurs due to reactive oxygen species during ischemic insult. This study aimed investigate IMA production stress induced MV <b>Materials Methods</b> included 17 neonates were ventilated using synchronized intermittent mechanical...

Abstract Objective: Determination of the factors associated with intensive care unit (ICU) prognosis and mortality has important role in clinical follow-up patients. Definition novel biomarkers, beside older biomarkers available for evaluation outcome these patients been proposed. Platelet-activating factor acetylhydrolase (PAF-AH) is an enzyme that inactivates platelet-activating factor. A reduction level PAF-AH demonstrated during systemic inflammation multiple organ failure. This research...

Objective: Paraoxonase-2 (PON2) is a cellular enzyme that has antioxidant properties similar to PON1, an HDL-associated serum playing important role in the prevention of atherosclerosis. 1. The aim this study investigate whether paraoxonase activity and PON2 Ser311Cys polymorphism are related coronary artery disease extent Methods: Blood specimens were collected from 131 individuals who had no lesions angiographically 110 angiographically-documented at several degrees. severity arterial...

Background and aims: Mechanical ventilation (MV) can induce oxidative stres. Ischemia-modified albumin (IMA) is a new biomarker for the identification of myocardial ischemia. This study aimed to investigate IMA production by induced stress during MV in newborns. Methods: cross-sectional was performed between September 2012 June 2012. Seventeen newborns ventilated with SIMV (SIMV-group) 20 CPAP (CPAP-group) were included study. Two blood samples obtained from each (one them second sample...

Background and aims: Ischemia modified albumin (IMA) is a new marker for ischemic process. asphyxia are important pathogenetic initiator Hypoxic encephalopathy (HIE) but relationship between IMA HIE have not been investigated previously. Methods: Between 2012 2013 newborns hospitalized were prospectively followed in our NICU. was compared control groups. Statistical analysis performed by SPSS v.11.p value < 0.05 considered as significant. IRB approval taken. Results: There 27 with 39 normal...

Background and aims: Hypothermia is a recent popular treatment approach for the of hypoxic ischemic encephalopathy (HIE). On other hand, Ischemia modified albumin (IMA) new marker process. However, effect hypothermia on newborns with HIE who underwent was not investigated previously. Methods: Between 2012 2013, hospitalized were prospectively followed in our NICU. IMA, total antioxidant status (TOS), haemogram routine biochemical parameters blood gas analyses collected both before at end...