A5101731016- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Nutrition, Genetics, and Disease
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Genetic Neurodegenerative Diseases
- Synthesis and biological activity
- CRISPR and Genetic Engineering
- Oral microbiology and periodontitis research
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
Wuhan University
2021-2023
Renmin Hospital of Wuhan University
2021-2023
Southwest University
2022
State Key Laboratory of Silkworm Genomic Biology
2022
Central South University
2018-2021
Xiangya Hospital Central South University
2018-2021
Medical University of South Carolina
2021
Nantong University
2021
Auburn University
2014
The tumor-adipose microenvironment (TAME) is a universal microecosystem, that characterized by the dysfunction of lipid metabolism, such as excessive free fatty acids (FFAs). Macrophages are most abundant immune cell type within TAME, although their diversity in TAME not clear. We first reveal infiltration M2-like macrophages associated with poor survival breast cancer. To explore lipid-associated alterations we also detected levels FFAs transporters including acid binding proteins (FABPs)...
The current study aimed to investigate the mechanism by which exosomes secreted CHB patients with PNALT and liver inflammation grade (≥A2) affected development of cancer. Gene expression was assessed RT-PCR, Western blotting immunohistochemistry. CCK-8, colony formation, transwell, scratch-wound flow cytometry assays were used detect cell viability, proliferation, apoptosis metastasis. interaction TCF21 HHIP co-immunoprecipitation assay. Luciferase reporter combination TCF21/HHIP miR-25-3p....
Baculovirus is an important biological factor for controlling insect populations and represents a powerful tool gene delivery expression. However, the host receptor of baculovirus still unknown.
To investigate expression profiles of the plasma exosomal miRNAs chronic hepatitis B (CHB) patients with persistently normal alamine aminotransferase (PNALT) for first time and try to find which could reflect liver inflammation better. Methods: Five CHB tissue grade ≥A2 PNALT 5 <A2 were enrolled their blood samples collected. The exosomes extracted from these measured by electron microscope determine extraction effect. sent high throughput sequencing, in 2 groups was analyzed. Results: Under...
Objective: Regulatory quantitative trait loci (regQTL) theory can help to evaluate the regulation function of single nucleotide polymorphisms (SNPs) on crucial biological signals from a three-dimensional perspective. The aim this study was investigate effect these regQTL-SNPs susceptibility lung cancer. Methods: Based regQTL theory, using database identified cancer regQTL-SNPs, we screened SNPs that may as in reported susceptible regions by genome-wide association study(GWAS), and two-stage...
Background: Diabetes is at epidemic proportions, with the major form of fatality due to congestive heart failure triggered by myocardial infarction (MI). The impaired insulin signalling in diabetic leads energy dysregulation that compromises cardioprotective mechanism against ischemic injury. Therefore understanding how mitochondrial energetics altered would greatly advance knowledge base for improving outcomes from patients. Methods/Findings: We observed db/db mice (leptin deficient, type 2...