A5107978760- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- MicroRNA in disease regulation
- RNA modifications and cancer
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
- Diabetic Foot Ulcer Assessment and Management
- Circular RNAs in diseases
- Pituitary Gland Disorders and Treatments
- RNA Research and Splicing
- Spinal Dysraphism and Malformations
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
- Spinal Fractures and Fixation Techniques
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- TGF-β signaling in diseases
- Chromatin Remodeling and Cancer
- Wound Healing and Treatments
- Heat shock proteins research
- Chromatography in Natural Products
- Ear and Head Tumors
- Mathematical Biology Tumor Growth
Westlake University
2024
Zhejiang University
2024
Kunming Medical University
2013-2024
First Affiliated Hospital of Kunming Medical University
2013-2024
Capital Normal University
2024
Nantong University
2021-2022
Affiliated Hospital of Nantong University
2022
Yunnan Provincial Infectious Disease Hospital
2022
Nanjing Medical University
2019-2020
Yunnan Observatories
2012
Background/Aims: Parkinson’s disease (PD) is a frequently occurring condition that resulted from the loss of midbrain neurons, which synthesize neurotransmitter dopamine. In this study, we established mouse models PD to investigate expression microRNA-128 (miR-128) and mechanism through it affects apoptosis dopamine (DA) neurons excitatory amino acid transporter 4 (EAAT4) via binding axis inhibition protein 1 (AXIN1). Methods: Gene microarray analysis was performed screen differentially...
Purpose: To explore the involvement of N6-methyladenosine (m6A) modification in circular RNAs (circRNAs) and relevant methyltransferases lesion lens epithelium cells (LECs) under circumstances age-related cataract (ARC). Methods: LECs were collected from normal subjects patients with cortical type ARC (ARCC). M6A-tagged circRNAs expression analyzed by m6A-modified RNA immunoprecipitation sequencing (m6A-RIP-seq) (RNA-seq). Gene Ontology (GO) annotation Kyoto Encyclopedia Genes Genomes (KEGG)...
<title>Abstract</title> <bold>Background</bold> Vagus nerve stimulation (VNS) is recognized for its therapeutic potential in various neurological disorders, with clinical and preclinical evidence suggesting capacity to enhance memory function beyond symptom alleviation. However, the mechanisms underlying VNS-mediated enhancement are not well understood. Given that hippocampal noradrenergic (NE) system β-adrenergic receptor (β-AR) pathway linked processes, this study investigated effects of...
The role and mechanism of collagen type VI alpha 6 (COL6A6) on tumor growth metastasis in pituitary adenoma (PA) was determined. COL6A6 downregulated PA tissues cell lines, which negatively associated with the expression prolyl-4-hydroxylase polypeptide III (P4HA3) progression PA. Overexpression significantly suppressed capacity In addition, P4HA3 worked as upstream PI3K-Akt pathway to alleviate antitumor activity both AtT-20 HP75 cells. Furthermore, inhibitory effect proliferation,...
The present study was designed to explore the correlation between serum S100β levels and cognitive dysfunction in patients with cerebral small vessel disease (SVD). A total of 172 SVD participated study, they were assigned no impairment (NCI group) those vascular dementia (VCIND group). In total, 105 people recruited into normal control group. Serum protein level detected by ELISA. receiver operating characteristic (ROC) curve employed for predictive value diagnosing dysfunction. Pearson...
Tupaia belangeri (tree shrew), an animal species whose genome has significantly higher similarity to primates than rodents, been used in biomedical research. To generate models that reproduce the human tumors more faithfully we present first report of a cancer model mimicking tumor genetics tree shrew. By engineering lentiviral system for transduction mutant H-Ras and shRNA against shrew p53, successfully generated malignant glioma The exhibited aggressive behavior relatively short latency,...
The study indicates inflammation and autophagy are closely related to neural apoptosis in the pathology of ischemic stroke. In study, we investigate effects mechanisms extracts Angelica sinensis Cinnamomum cassia (AC) from oriental medicinal foods on inflammatory autophagic pathways rat permanent middle cerebral artery occlusion model. Three doses AC extract were, respectively, administered for 7 days. It suggests that treatment ameliorated scores motor sensory functions ratio glucose...
Glioblastoma (GBM) cells have the potential to switch from being "proliferative cells" peritumoral "invasive cells". Peritumoral GBM highly invasive properties that allow them survive surgery, leading recurrence. The mechanisms underlying manner in which tumor microenvironment (TME) regulates invasiveness of remain unclear. Single-cell RNA sequencing analysis revealed heterogeneity cells, microglia and macrophages. In this study, Oncostatin M receptor (OSMR) leukemia inhibitory factor (LIFR)...
Lung adenocarcinoma (LUAD) is a leading cause of mortality associated with cancer globally. Thus, it essential to elucidate its tumorigenesis and prognosis. Accumulating evidence shows that long noncoding RNAs (lncRNAs) play important roles in the occurrence progression tumors by regulating their glucose metabolism.Bioinformatics analysis was performed explore expression LINC00551 LUAD. The level LUAD cells tissues detected RT-qPCR. CCK-8, colony formation, EDU transwell assays were...
Background: Spinal cord injury (SCI) is a life-changing event with an extremely poor prognosis. In our preliminary studies, electroacupuncture (EA) was found to promote the repair of SCI, which closely related Notch signaling pathway. Therefore, in present study, we hypothesized that EA protects against SCI by inhibiting pathway and sought investigate underlying molecular mechanisms.
Background: The members of the Chromobox (CBX) family are important epigenetic regulatory molecules with critical biological roles in many tumors. However, no study has analyzed or verified their role lung adenocarcinoma (LUAD). Methods: UALCAN and Oncomine databases were used to analyze CBX expression LUAD, cBioPortal database was genetic variations. Kaplan-Meier plotter identify prognostic value. Gene Ontology pathway, receiver operating characteristic curves, tumor-infiltrating immune...
Abstract Background Vestibular schwannoma (VS) is a kind of benign tumor deriving from the acoustic nerve sheath. Substantial long non-coding RNAs (lncRNAs) were illustrated to have crucial roles in multiple cancers. However, few lncRNAs elucidated VS. Methods HCG11, miR-620 and ELK4 expression tested by RT-qPCR. Gain-of-function experiments conducted confirm effect HCG11 on Results possessed low VS cell lines. Overexpression repressed proliferation but accelerated apoptosis cells. Moreover,...
Growing evidence indicates that p53 can regulate the expression of miRNAs, especially miR-34 family members, which are described as potential tumor suppressors. Loss impairs TP53-mediated cell death, whereas over induced apoptosis. The study aimed to investigate association between pir-miR-34b/c rs4938723, TP53 Arg72Pro and risk glioma. We genotyped two polymorphisms in175 glioma patients 235 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
By examining extramarital cohabitation in early twentieth-century China against intellectual, social, and legal contexts, this article shows the process by which educated class, mass media, state strived to understand locate new union inherited traditions emerging modern agendas. It especially focuses on controversy confusion between women involved these unions concubines whose presence caused social anxiety newly emerged gender relations governance. This argues that very actively...
Abstract Background Lennox-gastaut syndrome (LGS) is an epileptic encephalopathy often associated with behavioral and psychiatric disorders. Vagus nerve stimulation (VNS) has been approved effective for LGS treatment. Surgical resection also option patients focal pathology, offering a high probability of seizure control. However, it challenging to accurately localize the focus. Case presentation The case presented here 19-year-old male 16-year history epilepsy comorbid severe cognitive He...