A5081921599- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Hair Growth and Disorders
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Genetic and Kidney Cyst Diseases
- Protein Degradation and Inhibitors
- Breast Cancer Treatment Studies
- Wound Healing and Treatments
- Cancer Mechanisms and Therapy
- Metastasis and carcinoma case studies
- Lipid metabolism and biosynthesis
- Islanding Detection in Power Systems
- Advanced Breast Cancer Therapies
- Access Control and Trust
- Security and Verification in Computing
- CRISPR and Genetic Engineering
- Philosophy, Ethics, and Existentialism
- Cancer Cells and Metastasis
- Hedgehog Signaling Pathway Studies
- Cloud Data Security Solutions
- Diversity and Impact of Dance
- Dietary Effects on Health
- Toxin Mechanisms and Immunotoxins
Westlake University
2022-2024
Harvard University
2024
Intellia Therapeutics (United States)
2023
Peking University
2015-2022
First Hospital of Jilin University
2020-2021
Jilin University
2020-2021
State Key Laboratory of Membrane Biology
2020-2021
Center for Life Sciences
2015-2017
King Center
2015
State Key Laboratory of Protein and Plant Gene Research
2015
BECN1/Beclin 1 is regarded as a critical component in the class III phosphatidylinositol 3-kinase (PtdIns3K) complex to trigger autophagy mammalian cells. Despite its significant role number of cellular and physiological processes, exact function BECN1 remains controversial. Here we created knockout human cell line using TALEN technique. Surprisingly, complete loss had little effect on LC3 (MAP1LC3B/LC3B) lipidation, LC3B puncta resembling autophagosomes by fluorescence microscopy were still...
Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common major clinical challenge. RNF8 ubiquitin E3 ligase that plays essential roles in DNA damage response; however, its role pathogenesis cancer unclear. Here, we report overexpressed positively correlates with expression p-Akt poor survival patients non-small-cell cancer. In addition, identify as regulating activation Akt by K63-linked ubiquitination under physiological...
Cyclin-dependent kinase 7 (CDK7) is crucial for cell cycle progression and gene expression transcriptional regulation, which are often not assessed in cancer developing process. CDK7 inhibitors have emerged as promising drugs treating diverse cancers, including breast cancer. However, the mechanism behind its anticancer effect has been well investigated. Here, possible of human triple-negative (TNBC) studied. The effects on cells identified by measuring viability (Cell Counting Kit-8)...
Autophagy is a bulk cell-degradation process that occurs through the lysosomal machinery, and many reports have shown it participates in microbial pathogenicity. However, role of autophagy Clostridium difficile infection (CDI), leading cause antibiotics-associated diarrhea, pseudomembranous colitis even death severe cases, not clear. Here we report major virulent factor toxin B (TcdB) elicits strong response host cells its glucosyltransferase activity. Using variety autophagy-deficient cell...
Higher cyclin-dependent kinase (CDK7) expression is a character of breast cancer and indicates poor prognosis. Inhibiting CDK7 exhibited effective cell suppression which implies the potential inhibition to be method for anti-cancer treatment. Our study aimed explore novel mechanism suppressing survival. Here, we proved inhibiting repressed proliferation colony formation increased apoptotic rate, with p53 GSDME protein level elevation. When was suppressed in MCF-7 cells, decline associated...
Large language models (LLMs) have made remarkable strides in complex reasoning tasks, but their safety and robustness processes remain underexplored. Existing attacks on LLM are constrained by specific settings or lack of imperceptibility, limiting feasibility generalizability. To address these challenges, we propose the Stepwise rEasoning Error Disruption (SEED) attack, which subtly injects errors into prior steps to mislead model producing incorrect subsequent final answers. Unlike...
Abstract 1.1 Background Slug as a member of the epithelial-mesenchymal transition(EMT) leads to decrease adhesion between cancer cells and increase cell migration. Many studies have been reported relationship prognosis slug expression in patients with breast cancer, yet results are controversial. Therefore, it is necessary conclude by meta-analysis. 1.2 Methods We looked for on via PubMed, Scopus Web Science .A total 1458 from final eight were included this Overall survival (OS) Disease-free...
<h3>Background</h3> The success of T cell therapies for the treatment solid tumors has been limited. Factors limiting efficacy in are poor infiltration, exhaustion, and an immunosuppressive tumor microenvironment (TME). <h3>Methods</h3> To address these issues, we developed multiple mouse syngeneic models to conduct <i>in vivo</i> CRISPR screening identify Immune Enhancing Edits (IEEs) that augment CD8+ function across TMEs. Several IEEs were validated models, displaying significant control....
Despite the tremendous success of targeted and conventional therapies for lung cancer, therapeutic resistance is a common major clinical challenge. RNF8 ubiquitin E3 ligase that plays essential roles in DNA damage response; however, its role pathogenesis cancer unclear. Here, we identified carcinogenesis chemoresistance cancer. overexpressed positively correlates with expression p-Akt poor survival non-small cell patients. In addition, as regulating activation Akt via K63-linked...
Abstract Background Metformin, which is cheap and easy to get, a first-line anti-hyperglycemia drug. Recently, its anti-tumor effect has been revealed. Here we performed meta-analysis summarize previous studies narrative review gather the mechanisms involved in potential relationship. Methods We searched related articles database of Pubmed, EMbase, Web science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Sinomed obtained 8 clinic trials that investigated...