A5008947441- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Cerebral Palsy and Movement Disorders
- Extracellular vesicles in disease
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Epilepsy research and treatment
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Autism Spectrum Disorder Research
- Glioma Diagnosis and Treatment
- Interactive and Immersive Displays
- Pediatric health and respiratory diseases
- Circular RNAs in diseases
- Insect and Arachnid Ecology and Behavior
- Medicinal Plants and Bioactive Compounds
- Immunotherapy and Immune Responses
- Spinal Dysraphism and Malformations
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal properties of materials
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
Ministry of Agriculture and Rural Affairs
2025
Beijing University of Agriculture
2025
Chinese Academy of Agricultural Sciences
2025
Guangzhou University of Chinese Medicine
2023-2024
Jinan University
2018-2023
Chang'an University
2020
Shanxi Provincial Children's Hospital
2019-2020
Beijing Sanbo Brain Hospital
2017-2019
Capital Medical University
2017-2019
Liaoning University of Traditional Chinese Medicine
2011
Autistic spectral disorder (ASD) is one prevalent neurodevelopmental disease that affects multiple brain regions. Both clinical and animal studies are revealing the possible involvement of cerebellum in ASD pathology. In this study, we generated a rodent model by single prenatal administration valproic acid (VPA) into pregnant mice, followed cerebellar morphological functional on offspring. Behavioral showed VPA exposure led to retardation critical motor reflexes juveniles, impaired learning...
Myelin-laden macrophages (mye-MΦ), resulting primarily from internalization of myelin debris by infiltrating bone marrow-derived in spinal cord injury (SCI), trigger inflammatory responses that largely contribute to secondary injury. Adiponectin, which is secreted adipose tissue, an important hormone modulates macrophage inflammation. In the present study, we examined role adiponectin on macrophage-mediated neuroinflammation after SCI. We found vitro activation receptors (AdipoRs) their...
Purpose: Growing evidence has valued the diagnostic and therapeutic ability of long non-coding RNAs (lncRNAs) in various human tumors including glioma. Here, we investigated biological function potential mechanism a novel cancer-related lncRNA, HOXC-AS2, Materials methods: The expression lncHOXC-AS2 was detected using qRT-PCR glioma cells tissues. A series vitro studies were performed to analyze lncHOXC-AS2. Dual-luciferase reporter, RIP used determine relation between lncHOXC-AS2,...
MicroRNAs (miRs) have been found to play promoting or suppressive roles in different human cancers. However, the exact regulatory mechanism of miR-30b glioblastoma remains unknown. Here we shown that expression is significantly increased tissues and cell lines. Moreover, a high associated with shorter survival time for patients. Knockdown caused significant reduction proliferation, migration, invasion U87 A172 cells. Proline-rich transmembrane protein 2 (PRRT2) was further identified as...
As an empirical medicine of traditional Chinese medicine, Fuzhengjiedu Granules have shown effect against COVID-19 in clinical and inflammatory animal models. It is formulated with eight herbs, including Aconiti Lateralis Radix Praeparata, Zingiberis Rhizoma, Glycyrrhizae Et Lonicerae Japonicae Flos, Gleditsiae Spina, Fici Radix, Pogostemonis Herba, Citri Reticulatae Pericarpium. This study established a high-performance liquid chromatography-triple quadrupole mass spectrometry...
Objective To assess changes in plasma exosome levels and protein content mice after long-term exercise. Methods We subjected 9-month-old adult C57BL/6J to daily treadmill running exercise for 4 weeks prior the isolation of blood-derived exosomes. Exosomal proteins were identified using mass spectrometry. Results Extracellular bodies successfully isolated from mouse blood. Protein altered exosomes chronic Levels secretagogue secretogranin 2 markedly elevated exercise-induced Conclusion Our...
Experimental evidence has shown that chimeric switch receptor T (CSR-T) cells, activated by binding programmed death-ligand 1 on the tumor cell surface, lead to regression in experimental animals. In this phase I clinical study, we evaluated safety and bioactivity of CSR-T therapy 14 patients with recurrent glioblastoma who were unresponsive surgical resection standard radiotherapy. Patients received 108 cells either intravenously or intracranially showed an increase levels IFN-gamma IL-6,...
PurposeTo identify risk factors for the recurrence of convulsions with mild gastroenteritis (CwG)1 in children.MethodsAltogether, 613 children CwG admitted to Children's Hospital Shanxi Province from January 2010 December 2015 were selected, their clinical data retrospectively analyzed, and patients followed up 4–10 years. Risk analyzed based on characteristics children.ResultsRelapse occurred 35 (6.3 %). Recurrence within 6 months after first majority (80 %), once most (91.4 associated age...
Amino acids are an essential source of human protein, and their content composition the main factors determining food protein utilization rate. Determining amino is in component analysis food. Therefore, a groundbreaking technique was developed utilizing ultra-high performance liquid chromatography interfaced with triple quadrupole mass spectrometer (UHPLC-QQQ-MS/MS) for concurrently quantifying 18 across various types meat. According to test results, it can be known that average glutamate (2.03 × 10
Objective To explore the clinical symptoms, treatment strategies and prognoses of occult tethered cord syndrome (OTCS) in children. Methods Sixteen children with OTCS underwent operations at Neurosurgery Department Shanxi Children’s Hospital from April 2007 to 2013 whose data were retrospectively analyzed. The radiological examination, urodynamic test, complications those patients documented. Among all 16 cases, symptoms included urinary incontinence (n=9), bowel (2), cutaneous...