A5101515019- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- Birth, Development, and Health
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Fire effects on ecosystems
- Bacillus and Francisella bacterial research
- Colorectal Cancer Surgical Treatments
- Spaceflight effects on biology
- Antiplatelet Therapy and Cardiovascular Diseases
- Complement system in diseases
- Congenital heart defects research
- Monoclonal and Polyclonal Antibodies Research
- Research on Leishmaniasis Studies
- Escherichia coli research studies
- Cardiovascular Health and Risk Factors
- Reproductive System and Pregnancy
- Viral Infections and Immunology Research
Johns Hopkins University
1993-2025
AbbVie (United States)
2022-2024
Western University
2024
Johns Hopkins Medicine
2023
PhaseBio Pharmaceuticals (United States)
2019-2023
American College of Surgeons
2023
Bloomberg (United States)
2023
Advanced Bioscience Laboratories (United States)
2023
Biomedical Advanced Research and Development Authority
2018-2022
Fox Chase Cancer Center
2004-2021
Human fibroblast activation protein (FAP)/seprase is a 97-kDa surface glycoprotein expressed on tumor associated fibroblasts in the majority of epithelial cancers including colon adenocarcinomas. FAP overexpression human cells has been shown to promote growth animal models, and clinical trials targeting enzymatic activity have initiated. The primary objective this study was evaluate significance stromal by immunohistochemisty.Sections paraffin-embedded resected cancer specimens from 1996...
In December 2006, Rift Valley fever (RVF) was diagnosed in humans Garissa Hospital, Kenya and an outbreak reported affecting 11 districts. Entomologic surveillance performed four districts to determine the epidemic/epizootic vectors of RVF virus (RVFV). Approximately 297,000 mosquitoes were collected, 164,626 identified species, 72,058 sorted into 3,003 pools tested for RVFV by reverse transcription-polymerase chain reaction. Seventy-seven representing 10 species positive RVFV, including...
ABSTRACT In order to investigate the prevalence of tick-borne infectious agents among ticks, ticks comprising five species from two genera ( Hemaphysalis spp. and Ixodes spp.) were screened using molecular techniques. Ticks (3,135) collected small wild-caught mammals or by dragging/flagging in Republic Korea (ROK) pooled into a total 1,638 samples (1 27 per pool). From tick samples, species-specific fragments Anaplasma phagocytophilum sample), platys (52 samples), Ehrlichia chaffeensis (29...
Ticagrelor is an oral P2Y12 inhibitor that used with aspirin to reduce the risk of ischemic events among patients acute coronary syndromes or previous myocardial infarction. Spontaneous major bleeding and associated urgent invasive procedures are concerns ticagrelor, as other antiplatelet drugs. The effects ticagrelor cannot be reversed platelet transfusion. A rapid-acting reversal agent would useful.
ABSTRACT There are no vaccines or therapeutics currently approved for the prevention treatment of ebolavirus infection. Previously, a replicon vaccine based on Venezuelan equine encephalitis virus (VEEV) demonstrated protective efficacy against Marburg in nonhuman primates. Here, we report Sudan (SUDV)- and Ebola (EBOV)-specific VEEV particle (VRP) VRP were developed to express glycoprotein (GP) either SUDV EBOV. A single intramuscular vaccination cynomolgus macaques with expressing GP...
ABSTRACT Adult females of reproductive age develop greater antibody responses to inactivated influenza vaccines (IIV) than males. How sex, age, and sex steroid concentrations impact B cells durability IIV-induced immunity protection over 4 months post-vaccination (mpv) was analyzed. Vaccinated adult had germinal center cell plasmablast frequencies in lymphoid tissues, higher neutralizing 1–4 mpv, better against live H1N1 challenge Aged mice, regardless reduced frequencies, less durable...
Bacterial biofilm formation is a complex developmental process involving cellular differentiation and the of intricate 3D structures. Here we demonstrate that exposure to ferric chloride triggers rugose by uropathogenic Escherichia coli strain UTI89 enteric bacteria Citrobacter koseri Salmonella enterica serovar typhimurium . Two unique separable populations emerge in iron-triggered, biofilms. Bacteria at air–biofilm interface express high levels regulator csgD , cellulose activator adrA...
ABSTRACT Enteric bacteria, such as Escherichia coli , are exposed to a variety of stresses in the nonhost environment. The development biofilms provides E. with resistance environmental insults, desiccation and bleach. We found that biofilm formation, specifically production matrix components curli cellulose, protected against killing by soil-dwelling nematode Caenorhabditis elegans predatory bacterium Myxococcus xanthus . Additionally, matrix-encased bacteria at air-biofilm interface...
We investigated the prevalence of Bartonella infections in ticks, mites and small mammals (rodents, insectivores weasels) collected during 2001 through 2004, from various military installations training sites Korea, using PCR sequence analysis 16S rRNA, 23S rRNA groEL heat shock protein genes. The spp. was 5.2% (n = 1,305 sample pools) 19.1% 21) mesostigmatid 13.7% 424 individuals) mammals. within family Ixodidae was, 4.4% 1,173) Haemaphysalis longicornis (scrub tick), 2.7% 74) H. flava,...
Human vascular malformations cause disease as a result of changes in blood flow and hemodynamic forces. Although the genetic mutations that underlie formation many human are known, extent to which abnormal can subsequently influence program natural history is not. Loss SH2 domain–containing leukocyte protein 76 kDa (SLP76) resulted malformation directed through mesenteric lymphatic vessels after birth mice. Mesenteric position congenital mature Slp76-null mice lacked identity expressed...
Nucleic acid aptamers have long demonstrated the capacity to bind viral envelope proteins and inhibit progression of pathogenic virus infections. Here we report on initial efforts develop screen DNA against recombinant or synthetic peptides whole inactivated viruses from several virulent arboviruses including Chikungunya, Crimean-Congo hemorrhagic fever (CCHF), dengue, tickborne encephalitis West Nile viruses. We also analyzed sequence data secondary structures for commonalities that might...
BACKGROUND: Ticagrelor is a reversible oral P2Y12 platelet inhibitor used to treat patients with acute coronary syndromes, prior myocardial infarction, high-risk artery disease, transient ischemic attack, or stroke. A healthy volunteer study showed that the intravenous monoclonal antibody bentracimab rapidly reverses ticagrelor, but effect in was unknown. METHODS: In prespecified interim analysis of single-arm, prospective study, evaluated ticagrelor-treated who required urgent surgery had...
Pregnant women are at heightened risk for severe outcomes from many infectious diseases, including COVID-19. However, they were not included in the initial COVID-19 vaccine clinical trials and current rates of uptake among pregnant remain below 15%. We explored serological cellular responses to mRNA booster vaccines (i.e., ancestral BA.5) age-matched non-pregnant females identify how pregnancy affects immunity against viruses addition novel variants. Blood was collected participants prior...
Solid organ transplant recipients (SOTRs) suffer more frequent and severe infections due to their compromised immune responses resulting from immunosuppressive treatments designed prevent rejection. Pharmacological immunosuppression can adversely affect vaccination. A cohort of kidney (KTRs) received third dose ancestral, monovalent COVID-19 vaccine in the context a clinical trial antibody strain, as well two Omicron variants BA.1 BA.5 were investigated compared with healthy controls who...
We report here a previously unrecognized mosquito species from the Republic of South Korea that is closely related to Anopheles (Anopheles) sinensis. also present an rDNA ITS2-based method for identification this and other morphologically similar country. The PCR assay multiplex seven primers in single reaction unambiguously identifies all included species. include An. sinensis, lesteri, pullus, reported unknown Anopheles. Based on ITS2 sequence, two unnamed have genetic distances sinensis...
One of the most significant modern day efforts to prevent and control an arthropod-borne disease during a military deployment occurred when team U.S. entomologists led characterize, prevent, leishmaniasis at Tallil Air Base (TAB), Iraq, Operation Iraqi Freedom. Soon after arriving TAB on 22 March 2003, determined that 1) high numbers sand flies were present TAB, 2) individual soldiers receiving many fly bites in single night, 3) Leishmania parasites 1.5% female as using real-time...
Background. During the Rift Valley fever (RVF) epidemic of 2006–2007 in eastern Africa, spatial mapping outbreaks across Kenya, Somalia, and Tanzania was performed RVF viruses were isolated genetically characterized.
A structural investigation of sub-15 nm xEu:BaTiO3 nanocrystals (x = 0–5 mol%) was conducted to determine the distribution Eu3+ ion in BaTiO3 lattice. Pair function analysis X-ray total scattering data (PDF), steady-state photoluminescence, and absorption spectroscopy (XANES/EXAFS) were employed interrogate crystal structure local atomic environment ion. The solubility limit nanocrystalline host synthesized via vapor diffusion sol–gel method estimated be ∼4 mol%. contraction perovskite unit...
The Ebola virus disease outbreak that occurred in Western Africa from 2013–2016, and subsequent smaller but increasingly frequent outbreaks of recent years, spurred an unprecedented effort to develop deploy effective vaccines, therapeutics, diagnostics. This led the U.S. regulatory approval a diagnostic test, two therapeutics for indications. Moreover, establishment fieldable tests improved speed with which patients can be diagnosed public health resources mobilized. United States government...