A5019152371- Cardiac, Anesthesia and Surgical Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Trauma and Emergency Care Studies
- Sepsis Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Clusterin in disease pathology
- Abdominal Surgery and Complications
- Cardiac Arrest and Resuscitation
- Appendicitis Diagnosis and Management
- SARS-CoV-2 and COVID-19 Research
- Climate Change and Health Impacts
- Clinical practice guidelines implementation
- Zoonotic diseases and public health
- Parathyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Innovations in Medical Education
- Hip and Femur Fractures
- Immune Response and Inflammation
- Pancreatitis Pathology and Treatment
- Renal and Vascular Pathologies
- Bat Biology and Ecology Studies
Atrium Health Wake Forest Baptist
2025
University of Pittsburgh Medical Center
2019-2023
University of Pittsburgh
2021-2023
Institute for Transfusion Medicine
2023
The University of Texas at San Antonio
2022
The University of Texas Health Science Center at San Antonio
2022
University of Utah
2022
University of Arizona
2022
University of North Carolina at Chapel Hill
2012-2017
Indiana University School of Medicine
2017
ABSTRACT The relationship between bats and coronaviruses (CoVs) has received considerable attention since the severe acute respiratory syndrome (SARS)-like CoV was identified in Chinese horseshoe bat (Rhinolophidae) 2005. Since then, several throughout world have been shown to shed sequences, presumably CoVs, feces; however, no CoVs isolated from nature. Moreover, there are very few cell lines or reagents available for investigating replication cells isolating adapted specific species. Here,...
Rapid source control is recommended to improve patient outcomes in sepsis. Yet there are few data guide how rapidly required.To determine the association between time and community-acquired sepsis.Multihospital integrated health care system cohort study of hospitalized adults (January 1, 2013, December 31, 2017) with sepsis as defined by Sepsis-3 who underwent procedures. Follow-up continued through January 2019, analyses were completed March 17, 2022.Early (<6 hours) compared late (6-36...
Leucine-rich α2 glycoprotein (LRG1), a serum protein produced by hepatocytes, has been implicated in angiogenesis and tumor promotion. Our laboratory previously reported the expression of LRG1 murine myeloid cell lines undergoing neutrophilic granulocyte differentiation. However, presence primary human neutrophils role for regulation hematopoiesis have not described. Here we show that is packaged into granule compartment secreted upon neutrophil activation to modulate microenvironment. Using...
Objective: We sought to characterize the timing of administration prehospital tranexamic acid (TXA) and associated outcome benefits. Background: TXA has been shown be safe in setting post-injury. Methods: performed a secondary analysis recent randomized clinical trial injured patients. Those who received within 1 hour (EARLY) from time injury were compared those beyond (DELAYED). included patients with shock index >0.9. Primary was 30-day mortality. Kaplan-Meier Cox Hazard regression...
The authors sought to identify causal factors that explain the selective benefit of prehospital administration thawed plasma (TP) in traumatic brain injury (TBI) patients using mediation analysis a multiomic database.The Prehospital Air Medical Plasma (PAMPer) Trial showed with TBI and pronounced systemic response [defined as endotype 2 (E2)], have survival from TP. An interrogation high dimensional proteomics, lipidomics metabolomics previously demonstrated unique patterns circulating...
In the Study of Tranexamic Acid During Air and Ground Prehospital Transport (STAAMP) Trial, prehospital tranexamic acid (TXA) was associated with lower mortality in specific patient subgroups. The underlying mechanisms responsible for a TXA benefit remain incompletely characterized. We hypothesized that may mitigate endothelial injury sought to assess whether decreased or tissue damage markers among all patients enrolled STAAMP Trial.We collected blood samples from Trial measured function...
Severe injury is known to cause a systemic cytokine storm that associated with adverse outcomes. However, comprehensive assessment of the time-dependent changes in circulating levels broad spectrum protein immune mediators and soluble mediator receptors severely injured trauma patients remains uncharacterized. To address this knowledge gap, we defined temporal outcome-based patterns 184 circulation patients. Proteomics (aptamer-based assay, SomaLogic, Inc) was performed on plasma samples...
BACKGROUND Growing evidence supports improved survival with prehospital blood products. Recent trials show a benefit of tranexamic acid (TXA) administration in select subgroups. Our objective was to determine if receiving packed red cells (pRBC) addition TXA injured patients at risk hemorrhage. METHODS We performed secondary analysis all scene from the Study Tranexamic Acid during Air and ground Medical Prehospital transport trial. Patients were randomized or placebo. Some participating EMS...
Admission-based circulating biomarkers for the prediction of outcomes in trauma patients could be useful clinical decision support. It is unknown which molecular classes biomolecules can contribute to predictive modeling. Here, we analyzed a large multi-omic database over 8500 markers (proteomics, metabolomics, and lipidomics) identify prognostic compartment adverse outcomes, including mortality slow recovery, severely injured patients. Admission plasma samples from (n = 129) enrolled...