A5061229251- Chronic Lymphocytic Leukemia Research
- Genetics and Physical Performance
- Adipose Tissue and Metabolism
- Acute Myeloid Leukemia Research
- Galectins and Cancer Biology
- Cancer therapeutics and mechanisms
- Muscle Physiology and Disorders
- Glycosylation and Glycoproteins Research
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Antifungal resistance and susceptibility
- PI3K/AKT/mTOR signaling in cancer
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Renal Transplantation Outcomes and Treatments
- Mycobacterium research and diagnosis
- Sports Performance and Training
- Pharmacological Effects and Toxicity Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Biochemical and Molecular Research
- Exercise and Physiological Responses
- RNA Research and Splicing
Levine Cancer Institute
2017-2024
Atrium Health Wake Forest Baptist
2024
Wake Forest Baptist Comprehensive Cancer Center
2024
Atrium Medical Cente
2019
Carolinas Healthcare System
2017
Carolinas Medical Center
2010-2014
University of North Carolina at Charlotte
2009-2014
University of Pavia
2013
Sarah Cannon
2013
Texas A&M University
2010
Previous genetic association studies of physical activity, in both animal and human models, have been limited number subjects genetically homozygous strains used as well genomic markers available for analysis. Expansion the mouse activity strain screens recently published dense single-nucleotide polymorphism (SNP) map genome (≈8.3 million SNPs) associated statistical methods allowed us to construct a more generalizable quantitative trait loci (QTL) with activity. Specifically, we measured...
PURPOSE Fluoropyrimidine-related toxicity and mortality risk increases significantly in patients carrying certain DPYD genetic variants with standard dosing. We implemented genotyping at a multisite cancer center evaluated its impact on dosing, toxicity, hospitalization. METHODS In this prospective observational study, receiving (reactive) or planning to receive (pretreatment) fluoropyrimidine-based chemotherapy were genotyped for five as practice per provider discretion. The primary end...
There is a high risk of voriconazole failure in those with subtherapeutic drug concentrations, which more common CYP 2C19 (cytochrome P450 2C19) rapid/ultrarapid metabolizers ( RMs / UM s). We evaluated genotype‐guided dosing on concentrations and clinical outcomes adult allogeneic hematopoietic cell transplant recipients. Poor PM s), intermediate IM normal NM s) received 200 mg twice daily; s 300 daily. Steady‐state trough were obtained after 5 days, targeting 1.0–5.5 mg/L. Of 89 evaluable...
Abstract Purpose To describe the implementation of an in-house genotyping program to detect genetic variants linked impaired dihydropyrimidine dehydrogenase (DPD) metabolism at a large multisite cancer center, including barriers and mechanisms overcome facilitate test adoption. Summary Fluoropyrimidines, fluorouracil capecitabine, are commonly used chemotherapy agents in treatment solid tumors, such as gastrointestinal cancers. DPD is encoded by DPYD gene, individuals classified intermediate...
The regulatory mechanisms of physical activity are postulated to include environmental and biological/genetic factors. In particular, the sex steroids appear have profound effects on wheel running in rodents. purpose this project was investigate 17β-estradiol testosterone distance, duration, speed male female C57BL/6J mice. mice (N=46) were provided free access wheels interfaced with computers track daily speed. Activity assessed at baseline intact mice, after surgical gonadectomy,...
Highlights•CYP3A5 polymorphisms did not impact i.v. tacrolimus exposure post-transplant.•CYP3A4 and ABCB1 impacted post-transplant.•ABCB1 2677TT genotype was associated with increased risk of toxicity.•CYP3A4 C2677T genotyping may help individualize dosing.•Pharmacogenomic guidelines should acknowledge differences in versus oral tacrolimus.AbstractPharmacogenetics influences exposure; however, little data exist regarding tacrolimus. We investigated the genetic CYP3A4, CYP3A5, on toxicity...
Canonical Wnt signaling is important in skeletal muscle repair but has not been well characterized response to physiological stimuli. The objective of this study was assess the effect downhill running (DHR) on components signaling. Young, male C57BL/J6 mice were exposed DHR. Muscle injury and (MCadherin) measured soleus. Gene protein expression Wnt3a, active β-catenin, GSK3β, LEF1 gastrocnemius. increased 6 days post-DHR MCadherin 5 post-DHR. Total GSK3β decreased 3 (9-fold 3.6-fold,...
Fluoropyrimidine chemotherapy is a primary component of many solid tumor treatment regimens, particularly those for gastrointestinal malignancies. Approximately one-third patients receiving fluoropyrimidine-based chemotherapies experience serious adverse effects. This risk substantially higher in carrying DPYD genetic variants, which cause reduced fluoropyrimidine metabolism and inactivation (ie, dihydropyridine dehydrogenase [DPD] deficiency). Despite the known relationship between DPD...
Numerous candidate genes have been suggested in the recent literature with proposed roles regulation of voluntary physical activity, little evidence these genes' functional roles. This study compared haplotype structure and expression profile skeletal muscle brain inherently high- (C57L/J) low- (C3H/HeJ) active mice. Expression nine [Actn2, Actn3, Casq1, Drd2, Lepr, Mc4r, Mstn, Papss2, Glut4 (a.k.a. Slc2a4)] was evaluated via RT-qPCR. SNPs were observed regions Actn2, Papss2; however, no...
Alcoholic liver disease (ALD) affects millions of people worldwide and is a major cause morbidity mortality. However, fewer than 10% heavy drinkers progress to later stages injury, suggesting other factors in ALD development, including environmental exposures genetics. Females display greater susceptibility the early damaging effects ethanol. Estrogen (E2) ethanol metabolizing enzymes (cytochrome P450, CYP450) are implicated sex differences ALD. Sex steroid hormones developmentally regulated...
Abstract Purpose: Patients with chronic lymphocytic leukemia (CLL) treated ibrutinib are at risk of developing cardiovascular side effects (CVSE). The molecular determinants CVSEs have not been fully elucidated. We interrogated genetic polymorphisms in the Bruton tyrosine kinase (BTK) signaling pathway for their association ibrutinib-related CVSEs. Experimental Design: conducted a retrospective/prospective observational pharmacogenetic study 50 patients newly diagnosed or relapsed CLL who...
1534 Background: FPs, including 5-fluorouracil and capecitabine, are widely used to treat solid tumor malignancies like gastrointestinal (GI) cancers. One-third of patients (pts) develop severe toxicities which may lead treatment delays or hospitalization. Toxicities can be partly due genetic variations in DPYD. Herein, we describe the implementation an in-house DPYD test its impact on FP dosing at a multisite cancer hospital. Methods: This is observational study pts starting continuing...
Intravenous pentamidine is used for prophylaxis against Pneumocystis jirovecii pneumonia, an infection seen in hematopoietic stem cell transplant recipients. Pentamidine partially metabolized by CYP2C19, which vulnerable to pharmacogenetic variation. This retrospective study evaluated allogeneic patients who received intravenous as P. pneumonia prophylaxis. The primary objective was the association between CYP2C19 phenotype and discontinuation of due drug-related side effects based on...
It is well established that physical activity levels are significantly controlled by genetic factors; however, the specific genes and mechanisms involved in regulation of unknown. PURPOSE: To compare gene expression pattern several potential candidate both nucleus accumbens (brain) gastrocnemius/soleus (G/S muscle) between two differentially active inbred strains mice. METHODS: From previous experiments, acumbens G/S tissue were used from 11 high C57L/J (LJ) mice (8 male, 3 female) 13 low...