A5032845384- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Hematological disorders and diagnostics
- Clostridium difficile and Clostridium perfringens research
- Central Venous Catheters and Hemodialysis
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Infection Control in Healthcare
- Antibiotic Resistance in Bacteria
- Antifungal resistance and susceptibility
- Streptococcal Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Maternal and Perinatal Health Interventions
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Blood disorders and treatments
- Childhood Cancer Survivors' Quality of Life
- Fungal Infections and Studies
- Gut microbiota and health
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Pregnancy-related medical research
St. Jude Children's Research Hospital
2016-2025
Hopital Universitaire Hedi Chaker
2002-2024
University of Sfax
2024
University of Tennessee Health Science Center
2015-2024
Tel Aviv University
2023
Sheba Medical Center
2023
Weatherford College
2022
Creative Commons
2022
Office of Infectious Diseases
2007-2017
University of York
2013
Purpose To develop an evidence-based guideline for the empiric management of pediatric fever and neutropenia (FN). Methods The International Pediatric Fever Neutropenia Guideline Panel is a multidisciplinary multinational group composed experts in oncology infectious disease as well patient advocate. was convened purpose creating this guideline. We followed previously validated procedures guidelines. Working groups focused on initial presentation, ongoing management, antifungal therapy. Each...
Background The etiology, clinical course, and outcome of fever neutropenia (FN) in children with cancer using the current FN guidelines diagnostic resources United States have not been well described. Patients Methods Medical records a randomly selected episode per patient during 2004-2005 at pediatric oncology center were reviewed. managed as institutional blood cultures collected continuously read BACTEC bottles. Results Of 337 episodes, infection was proven 86 (25%) probable 75 (22%). In...
Infection is the most important cause of treatment-related morbidity and mortality in pediatric patients treated for acute lymphoblastic leukemia (ALL). Although routine adults with leukemia, antibacterial prophylaxis controversial pediatrics because insufficient evidence its efficacy or antibiotic choice concerns about promoting resistance Clostridium difficile infection. This was a single-center, observational cohort study newly diagnosed ALL, comparing prospectively collected...
There is an increased risk of infection in patients with cancer that results higher morbidity and mortality. Several factors can predispose these to infectious complications. Some such include immunocompromised states like neutropenia, allogeneic hematopoietic cell transplantation, graft-versus-host disease, while others immunosuppressive agents corticosteroids, purine analogs, monoclonal antibodies, other emerging therapeutics CAR T-cell therapy. The NCCN Guidelines for the Prevention...
Epstein-Barr virus (EBV) infection is associated with a broad spectrum of disease. While quantification EBV nucleic acid in the peripheral blood has been demonstrated to be useful for diagnosis and patient care, optimal sample type reporting format such testing remain uncertain. Using quantitative real-time PCR (QRT-PCR), we evaluated whole (WB), mononuclear cells (PBMC), plasma 249 samples from 122 patients. In WB PBMC, results were reported both viral copies/ml copies/microg total DNA....
To identify predictors for 2 risk measures-"proven invasive bacterial infection or culture-negative sepsis (IBD)" and "clinical complications (CC)"-in pediatric cancer patients with fever neutropenia (FN).Records of 390 FN hospitalized over years were reviewed. For the 332 who met inclusion criteria, one episode was randomly selected. Independent at presentation analyzed using multiple regression models. Optimal cut-off prediction scores determined. These models validated by bootstrap...
BACKGROUND Knowledge regarding the incidence, clinical course, and impact of respiratory viral infections in children with acute lymphoblastic leukemia (ALL) is limited. METHODS A retrospective cohort patients newly diagnosed ALL who were treated on Total Therapy XVI protocol at St Jude Children's Research Hospital between 2007 2011 was evaluated. RESULTS Of 223 children, 95 (43%) developed 133 episodes illness (ARI) (incidence, 1.1 per 1000 patient‐days). ARI without etiology identified 65...
OBJECTIVE Sepsis is associated with significant morbidity and mortality in pediatric hematology, oncology, transplant (PHOT) patients. This study characterized PHOT patients who developed hospital-onset sepsis more than 12 hours after admission identified risk factors for 30-day sepsis-attributable (SA) mortality. PATIENTS AND METHODS We analyzed an existing multicenter database of collected prospectively over 5 years (2017–2021) as part the Improving Pediatric Outcomes Collaborative. was...
Abstract Objective: Outbreaks of Pseudomonas aeruginosa infections have been linked to water-related sources. We describe the investigation a suspected outbreak five P. in pediatric oncology patients 2021 that triggered retrospective review and prospective monitoring additional cases, environmental sampling, bacterial genomic analysis. Setting patients: Pediatric center. Methods: Medical records with were reviewed staff interviewed identify common exposures. Environmental samples cultured...
Noroviruses are a leading cause of gastroenteritis worldwide. Although infections in healthy individuals self-resolving, immunocompromised at risk for chronic disease and severe complications. Chronic norovirus hosts often characterized by long-term virus shedding, but it is unclear whether this shed remains infectious. We investigated the prevalence, genetic heterogeneity, temporal aspects 1140 patients treated during 6-year period pediatric research hospital. Additionally, we identified 20...
Although antibiotic prophylaxis with levofloxacin can reduce the risk of serious infection in immunocompromised patients, potential contribution to resistance is a major drawback. We aimed identify effects prophylaxis, given paediatric patients acute lymphoblastic leukaemia prevent infections during induction chemotherapy, on gastrointestinal microbiota after completion and consolidation therapy.
Background Case investigations and contact tracing are essential disease control measures used by health departments. Early in the pandemic, they were seen as a key strategy to stop COVID-19 spread. The CDC urged rapid action scale up train large workforce collaborate across public private agencies halt transmission. Methods We developed program for case investigation that followed local guidelines, compliant with Occupational Safety Health Administration (OSHA) regulations tailored needs...
Abstract Background Pediatric hematology/oncology (PHO) patients receiving therapy or undergoing hematopoietic stem cell transplantation (HSCT) often require a central line and are at risk for bloodstream infections (BSI). There limited data describing outcomes of BSI in PHO HSCT patients. Methods This is multicenter ( n = 17) retrospective analysis who developed BSI. Centers involved participated quality improvement collaborative referred to as the Childhood Cancer Blood Disorder Network...
Single-center reports of central line-associated bloodstream infection (CLABSI) and the subcategory mucosal barrier injury laboratory-confirmed (MBI-LCBI) in pediatric hematology oncology transplant (PHO) patients have focused on inpatient setting. Characterization MBI-LCBI across PHO centers management settings (inpatient ambulatory) is urgently needed to inform surveillance prevention strategies.Prospectively collected data from August 1, 2013, December 31, 2015, CLABSI (including...
We describe a cluster of 6 pediatric hematopoietic cell transplant recipients with Lactobacillus bacteremia attributed to probiotic use. isolates cultured from probiotics and patients' blood were proven be related using whole-genome sequencing. Clinical studies are needed evaluate the safety use in immunocompromised patients.
Changes in oncology care and the diagnosis management of influenza over past several decades may have altered epidemiology outcomes pediatric patients.The clinical features 102 patients undergoing cancer therapy during 107 episodes between January 2002 April 2009 were retrospectively ascertained.Median age at time was 7.2 years (interquartile range: 3.8-11.2 years); 46% male. Nineteen (18%) recipients hematopoietic stem cell transplants. Patients' median absolute neutrophil lymphocyte counts...
ABSTRACT Bacillus cereus remains an important cause of infections, particularly in immunocompromised hosts. While typically associated with enteric disease manifestations can be quite diverse and include skin bacteremia, pneumonia, meningitis. Whether there are any genetic correlates bacterial strains particular clinical unknown. To address this gap understanding, we undertook whole-genome analysis B. isolated from patients a range manifestations, including noninvasive colonizing disease,...
The rupture of the gravid uterus is a rare complication trauma. It reported in less than one percent pregnant women who are victims road accidents. authors report case 26-year-old nulliparous patient presented with uterine resulting fetal death at 32 weeks gestation following nonpenetrating abdominal trauma traffic accident. An extreme emergency operation and laparotomy confirmed imaging findings led to conservative treatment splenectomy.