A5103163909- Rheumatoid Arthritis Research and Therapies
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Chronic Myeloid Leukemia Treatments
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Musculoskeletal Disorders and Rehabilitation
- Innovations in Medical Education
- Patient-Provider Communication in Healthcare
- Diversity and Career in Medicine
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare Systems and Technology
- Acute Lymphoblastic Leukemia research
- Biosimilars and Bioanalytical Methods
- Pelvic floor disorders treatments
- Patient Satisfaction in Healthcare
- Interprofessional Education and Collaboration
- Anorectal Disease Treatments and Outcomes
- Empathy and Medical Education
- Adolescent and Pediatric Healthcare
- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Spondyloarthritis Studies and Treatments
- Neuroblastoma Research and Treatments
Northumbria Healthcare NHS Foundation Trust
2014-2024
North Tyneside General Hospital
2016-2022
Royal Surrey County Hospital
2021-2022
Freeman Hospital
2002-2020
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2020
University College London Hospitals NHS Foundation Trust
2019
University College London
2019
Newcastle University
2014-2018
Norgine (United Kingdom)
2014-2016
NIHR Newcastle Biomedical Research Centre
2014-2016
Patients with active rheumatoid arthritis (RA) despite treatment biologic disease-modifying antirheumatic drug (bDMARD) therapy need options.To evaluate the effects of filgotinib vs placebo on signs and symptoms RA in a treatment-refractory population.A 24-week, randomized, placebo-controlled, multinational phase 3 trial conducted from July 2016 to June 2018 at 114 sites internationally, randomizing 449 adult patients (and treating 448) moderately severely inadequate response/intolerance 1...
Abstract Objective To compare work disability and job loss in early rheumatoid arthritis (RA) patients receiving adalimumab plus methotrexate (adalimumab + MTX) versus MTX alone. Methods In this multicenter, randomized, controlled trial, with RA for <2 years who had never taken self‐reported impairment were randomized to or placebo 56 weeks. Primary outcome was of any cause and/or imminent at after week 16. Secondary outcomes included disease activity, function (Health Assessment...
Hyperthyroidism associated with metastatic follicular carcinoma of the thyroid gland is rare. In one patient mass functioning tissue in primary and tumour was so great that excessive amounts thyroxine triiodothyronine were produced and, as a result, clinical hyperthyroidism developed. This spite fact activity per unit not supranormal may even have been slightly subnormal. The initial response metastases to 131I ablative therapy excellent.
To determine the effectiveness of a pictorial 'mind map' together with Arthritis Research Campaign (ARC) booklet for imparting knowledge to participants rheumatoid arthritis (RA). Also, we wished relate this their reading ability.We studied 363 RA. Reading ability was assessed using REALM, and Knowledge Scale Questionnaire (KSQ). Information on educational attainment, disease state levels anxiety depression also collected. Participants were randomly assigned receive either ARC alone or mind...
Objectives. The aim of this study was to determine an agreed set core regional musculoskeletal examination skills for medical students learn. Methods. Initially focus groups were undertaken amongst Rheumatologists, Orthopaedic Surgeons, Geriatricians and General Practitioners. These findings used inform the production a questionnaire survey. from both survey assessed using group nominative technique with national representation each four specialities involved. Results. This process has led...
Structured examination routines have been developed as educational resources for musculoskeletal clinical skills teaching, including Gait-Arms-Legs-Spine (GALS), Regional Examination of the Musculoskeletal System (REMS) and paediatric GALS (pGALS). In this study, we aimed to assess awareness use these in undergraduate medical teaching UK schools postgraduate practice.Electronic questionnaires were distributed adult leads at current doctors training.Responses received from 67 tutors...
The measurement of patient activity over prolonged periods has been attempted with accelerometer-based devices, but these summate total acceleration and deceleration time periods, are difficult to relate recognizable activities influenced by passive movement. We describe the development a portable monitor ambulation. This logs posture (sitting, standing lying) number vigour steps in real usually 24 h. is based on system position sensors an accelerometer which sampled when subject standing....
Abstract Introduction Methotrexate is routinely used to treat active disease in inflammatory arthritis. There have previously been patient safety concerns associated with methotrexate usage practice. Most patients commencing treatment are seen by the rheumatology nurse, receive education (often referred as drug counselling) on this agent prior starting treatment. Yet, there no recommended criteria regarding or experience ensure minimum competence of nurse. The objectives present survey were,...
Abstract Background The effects of filgotinib on patient-reported outcomes (PROs) from 3 trials in patients with active rheumatoid arthritis were investigated. Methods Methotrexate (MTX)-naïve received 200 or 100 mg plus MTX (FIL200+MTX, FIL100+MTX), monotherapy (FIL200), through 52 weeks (NCT02886728). Patients inadequate response (IR) to (MTX-IR) FIL200+MTX, FIL100+MTX, adalimumab 40 +MTX (ADA+MTX), placebo (PBO)+MTX (rerandomized FIL200+MTX FIL100+MTX at week 24) (NCT02889796). IR...
To evaluate efficacy and safety of filgotinib in Japanese RA patients who have failed or were intolerant to one more biologic disease-modifying antirheumatic drugs (bDMARD) from the global FINCH 2 study (NCT02873936).This subgroup analysis was performed using predefined statistical analyses. The is a randomized, double-blind, placebo-controlled, Phase 3 adult with inadequate response bDMARDs. randomized treated once-daily 200 mg, 100 mg placebo on background csDMARDs for 24 weeks.Of 449...
Abstract Aims Faecal incontinence affects up to 8% of adults. Associated social isolation and subsequent depression can have devastating effects on quality life (QoL). is an underreported health problem as the stigma that patients experience makes it difficult for sufferers discuss their condition with a physician. There been few well–designed, placebo‐controlled clinical trials treatment faecal little evidence available inform most appropriate management strategies. Libertas, robustly...
Faecal incontinence (FI) is distressing, significantly reduces quality of life (QoL) and has few pharmacological treatments. The α1-adrenoceptor agonist NRL001 (1R,2S-methoxamine hydrochloride) improves anal sphincter tone. efficacy was evaluated by changes in Wexner scores at week 4 vs. baseline NRL001-treated patients compared with placebo. Impact on QoL safety were also assessed. Four hundred sixty-six received (5, 7.5 or 10 mg) placebo as suppository, once daily over 8 weeks. score,...
OBJECTIVE--To determine if there is evidence for genetic anticipation in rheumatoid arthritis (RA) by analysing the possibility that parental disease status and age at proband conception influence of onset severity proband. METHOD--RA outpatients were identified data also taken from Newcastle multicase RA pedigrees. Comparisons made pedigrees grouped according to parents. Correlation coefficients linear regression models calculated probands. Measures compared mother-proband pairs....
Objective. To validate the objective monitoring of ambulatory activity as an outcome measure for rheumatoid arthritis (RA).